Ulcerative colitis Clinical Trials

Recruiting ulcerative colitis studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat ulcerative colitis. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting ulcerative colitis studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting ulcerative colitis trials

Within

ACT for Veterans With IBD and Mental Health Challenges

for Inflammatory Bowel Diseases

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07397195

Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease

for Crohn's Disease

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06510296

Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 5 - 17

Code: NCT05976802·Phase 4

Emerging Indications for Hyperbaric Oxygen Treatment

for Post-COVID-19 Condition

Sponsor: Jay C. Buckey Jr.

Sex: All·Age: All ages

Code: NCT07240649·Phase 4

Microbiome-targeted Diet Therapy in Ulcerative Colitis

for Ulcerative Colitis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07520461

Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07456566

Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation

for Ulcerative Colitis

1 site in Ann Arbor

Sponsor: Muhammad N Aslam, MD

Sex: All·Age: 5 - 80

Code: NCT07501078·Phase 2

Apply to this trial

Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Disease

1 site in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 85

Code: NCT07619547

Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis

for Crohn's Disease

9 sites incl. Lakeland

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT07697456·Phase 2

A Study on Infections in Adults With Ulcerative Colitis/Crohn's Disease

for Ulcerative Colitis

1 site in Cambridge

Sponsor: Takeda

Sex: All·Age: 65+

Code: NCT07250815

Heart Rate Variability (HRV) Biofeedback to Treat Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18 - 65

Code: NCT05892159

Proof of Concept Study Evaluating the Efficacy and Safety of ATH-063 Treatment in Patients With Relapsed/Refractory Moderately to Severely Active Ulcerative Colitis (UC)

for Ulcerative Colitis

2 sites incl. Miami

Sponsor: Athos Therapeutics Inc

Sex: All·Age: 18 - 75

Code: NCT07513181·Phase 2

Combination CurQD and Vedolizumab in Ulcerative Colitis

for Ulcerative Colitis

1 site in New York

Sponsor: Ryan C Ungaro

Sex: All·Age: 18 - 80

Code: NCT07665294·Phase 4

Role of Bile Acids and Microbiota in Clostridioides Difficile Infection in Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: Up to 17

Code: NCT06228352

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Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD

for Ulcerative Colitis

1 site in San Antonio

Sponsor: Spyre Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07652294·Phase 2

Development of the SC-IBD Self-Care Measurement Scale

for Inflammatory Bowel Diseases

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07494227

A Study of Ozanimod in Pregnant Women With Ulcerative Colitis and Their Offspring

for Ulcerative Colitis

1 site in Wilmington

Sponsor: Bristol-Myers Squibb

Sex: Female·Age: All ages

Code: NCT05953402

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Piloting an Insomnia Treatment in Patients With Ulcerative Colitis

for Insomnia

1 site in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT07428629

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Naturopathic Approaches to Ulcerative Colitis

for Ulcerative Colitis

1 site in Portland

Sponsor: National University of Natural Medicine

Sex: All·Age: 18+

Code: NCT07521904

Thermal Measurements of the Gut With a Colonoscope Compatible Thermal Probe

for Inflammatory Bowel Diseases

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07352995

A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)

for Colitis Ulcerative

9 sites incl. Anaheim

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 75

Code: NCT07463183·Phase 2

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Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Ulcerative Colitis and Crohn Disease

for Crohn Disease

Sponsor: Efferon JSC

Sex: All·Age: 18 - 65

Code: NCT07383597

Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population

for Ulcerative Colitis

Sponsor: University of Alberta

Sex: All·Age: 18+

Code: NCT07401680·Phase 1

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A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting

for Crohn's Disease

Sponsor: AbbVie

Sex: All·Age: 20+

Code: NCT07421258

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Efficacy of Acupuncture-Mesalazine Combination Therapy in Ulcerative Colitis.

for Ulcerative Colitis

Sponsor: Qin Yu

Sex: All·Age: 18 - 65

Code: NCT07389824

Desloratadine in Patients With Ulcerative Colitis

for Ulcerative Colitis (UC)

Sponsor: Tanta University

Sex: All·Age: 18 - 65

Code: NCT07333716·Phase 2

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A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

28 sites incl. Tucson

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07185009·Phase 3

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Study Evaluating ISM5411 Administered Orally to Subjects With Active Ulcerative Colitis (BETHESDA)

for Ulcerative Colitis

Sponsor: InSilico Medicine Hong Kong Limited

Sex: All·Age: 18 - 75

Code: NCT07265570·Phase 2

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LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

for Ulcerative Colitis

40 sites incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07186101·Phase 2

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Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

for Renal Cell Carcinoma

1 site in Pittsburgh

Sponsor: Diwakar Davar

Sex: All·Age: 18+

Code: NCT07223424·Phase 2

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A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)

for Ulcerative Colitis

14 sites incl. Phoenix

Sponsor: Takeda

Sex: All·Age: 2 - 17

Code: NCT06405087·Phase 3

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Study to Assess Change in Disease Activity of Risankizumab Treatment in Japanese Participants With Moderate to Severe Ulcerative Colitis

for Ulcerative Colitis

Sponsor: AbbVie

Sex: All·Age: 15+

Code: NCT07136116

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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

91 sites incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184996·Phase 3

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Study of Novel Therapeutics for Acute Remedy of Colitis

for Ulcerative Colitis

2 sites in Chestnut Hill

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT06420492·Phase 2

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Cohort of Patients With Ulcerative Colitis or Polyps Followed in CHU de Bordeaux Associated With a Biocollection - COLIBRI

for Ulcerative Colitis

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT07082231

A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Alfasigma S.p.A.

Sex: All·Age: 8 - 18

Code: NCT06865417·Phase 3

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A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

for Ulcerative Colitis

8 sites incl. Lancaster

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06979336·Phase 2

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Evaluation of a Remote Monitoring Application in the Follow-up of Patients With Active Inflammatory Bowel Diseases

for Crohn Disease

Sponsor: Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives

Sex: All·Age: 18 - 80

Code: NCT06742385

Apply to this trial

MOdel-Informed Precision Dosing of Ustekinumab and VEdolizumab in Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

Sponsor: Odense University Hospital

Sex: All·Age: 18+

Code: NCT06788340·Phase 4

Long-term Safety and Efficacy of Sacral Nerve Stimulation in Patients With Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Xijing Hospital

Sex: All·Age: 18 - 65

Code: NCT07114159

Apply to this trial

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

for Ulcerative Colitis

11 sites incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT07071519·Phase 3

Apply to this trial

Rupatadine in Patients With Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Alexandria University

Sex: All·Age: 18 - 70

Code: NCT07064707·Phase 2

Apply to this trial

A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis

for Ulcerative Colitis

21 sites incl. Escondido

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06975722·Phase 2

Apply to this trial

Ten Versus Fifteen Centimeter Pouch in IPAA Surgery

for Ulcerative Colitis

Sponsor: Odense University Hospital

Sex: All·Age: 18 - 60

Code: NCT06538402

Apply to this trial

A Comparative Evaluation of Different Histopathological Indices of Mucosal Healing in Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Assiut University

Sex: All·Age: 18 - 80

Code: NCT06918093

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

for Ulcerative Colitis

37 sites incl. Dothan

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 70

Code: NCT06937086·Phase 3

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Personalized Anti-Inflammatory Fibres in Ulcerative Colitis

for Ulcerative Colitis

Sponsor: University of Alberta

Sex: All·Age: 14+

Code: NCT06515210

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Efficacy of Subcutaneous Infliximab in Acute Severe Ulcerative Colitis: a Multicenter Retrospective Study

for Ulcerative Colitis

Sponsor: Central Hospital, Nancy, France

Sex: All·Age: 18+

Code: NCT06998797

Spondylo-arthritis Screening Tool Among Patient Suffering From Inflammatory Bowel Disease

for Spondylarthritis

Sponsor: University Hospital, Grenoble

Sex: All·Age: 18+

Code: NCT06998316

Nitazoxanide in Patients With Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Alexandria University

Sex: All·Age: 18 - 65

Code: NCT06993974·Phase 2

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A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)

for Crohn's Disease

2 sites incl. Glen Burnie

Sponsor: Takeda

Sex: All·Age: 18 - 75

Code: NCT06764615·Phase 2

Apply to this trial

Treatment of UC With Novel Therapeutics

for Ulcerative Colitis Mild

1 site in Chestnut Hill

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT06420375·Phase 2

Apply to this trial

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

for Ulcerative Colitis

26 sites incl. Canoga Park

Sponsor: Spyre Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07012395·Phase 2

Apply to this trial

Mirikizumab Real World Protocol

for Ulcerative Colitis

8 sites incl. Denver

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT06696014

Apply to this trial

Study of Efficacy and Adherence to Subcutaneous vs. Intravenous Vedolizumab in Patients With Inflammatory Bowel Disease Using a Novel Remote MONITORing Intervention

for Inflammatory Bowel Disease (IBD)

6 sites incl. New Orleans

Sponsor: Mercy Medical Center

Sex: All·Age: 18+

Code: NCT06750731

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An Observational Study to Evaluate Effectiveness and Safety of Upadacitinib in Chinese Adult Participants With Moderate to Severely Active Ulcerative Colitis (UC)

for Ulcerative Colitis

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06838845

Apply to this trial

Evaluation of Sleep Changes in Inflammatory Bowel Diseases (IBD) Patients.

for Disease Bowel

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18 - 65

Code: NCT05835973

Apply to this trial

A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

78 sites incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4

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A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Ulcerative Colitis on Advanced Therapies

for Ulcerative Colitis

Sponsor: All India Institute of Medical Sciences

Sex: All·Age: 18 - 75

Code: NCT06906445

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Tailored Anti-Inflammatory (A-I) Diet for Americans With Ulcerative Colitis (UC)

for Ulcerative Colitis

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 16 - 75

Code: NCT06784323

Apply to this trial

Ulcerative colitis clinical trials — common questions

Are ulcerative colitis clinical trials free to join?

Yes. Participating in a ulcerative colitis clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a ulcerative colitis clinical trial?

Each ulcerative colitis study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a ulcerative colitis trial near me?

Use the location controls above. We'll show recruiting ulcerative colitis trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many ulcerative colitis trials are recruiting right now?

We're currently tracking roughly 59 recruiting ulcerative colitis trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Ulcerative colitis trials by city

Birmingham, AL Los Angeles, CA Ann Arbor, MI Boston, MA Miami, FL Palo Alto, CA Anaheim, CA Denver, CO Garden Grove, CA Irvine, CA

Related specialties

Gastroenterology Inflammatory bowel disease Autoimmune disease