Utilizing CT Based Imaging Parameters of Body Composition to Understand Heterogeneity of Response to Biologic Therapies in Severe Asthma Cohorts

Part of paid clinical trials in Denver, Colorado.

Sponsor
University of Michigan
Study ID
NCT06922760
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Study Details

This study will utilize University of Michigan EMR data to form a retrospective cohort of severe asthma patients on biologic therapies for asthma with computed tomography (CT) imaging and known outcomes on therapy. These images will then be analyzed using morphomics, a combination of high-throughput image analysis and deep learning techniques, to derive imaging biomarkers that will be able to predict therapeutic response to biologics. These biomarkers will then be tested in a second cohort from the National Jewish Health to assess for validity.

Key Dates

Start date
Jan 15, 2021
Status verified
Nov 2025
Primary completion
Jul 31, 2024
Completion
Jul 31, 2024

Study Design

Enrollment
233 participants (actual)

Arms

  • Arm: University of Michigan, Ann Arbor, MI
    Severe asthma patients treated at Michigan Medicine who are on biologic therapies for asthma and who have CT imaging and known outcomes on therapy. No interventions were included in this retrospective study.
  • Arm: National Jewish Health, Denver, CO
    Severe asthma patients treated at National Jewish Health who are on biologic therapies for asthma and who have CT imaging and known outcomes on therapy. No interventions were included in this retrospective study.

Primary Outcome Measure

Chest Wall Muscle Size [ Time Frame: 28 months ]

Locations (2)

FacilityCityStateZIPSite coordinators
National Jewish HealthDenverColorado80206-
University of MichiganAnn ArborMichigan48109-

Find similar trials in Denver, CO

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
National Jewish Health· Denver, COUniversity of Michigan· Ann Arbor, MI

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