Lactate and Glycerol Contribution to Gluconeogenesis

Sponsor
Rutgers, The State University of New Jersey
Study ID
NCT06955130
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
40 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Glycerol — DRUG
    Subjects will receive an infusion of glycerol and glucagon.
  • Lactate — DRUG
    Subjects will receive an infusion of lactate and glucagon.
  • Glucose — DRUG
    Subjects will receive an infusion of glucose and glucagon.

Study Details

A major cause of increased blood glucose levels in type 2 diabetes (T2D) is increased hepatic gluconeogenesis (GNG), as the liver converts various substrates into glucose. Two of these substrates include glycerol, a molecule from fat, and lactate, a molecule that circulates in the blood. Our previously collected data suggest that glycerol's role in this process has been underestimated, so the investigators will directly compare the carbon contribution of glycerol and lactate to new glucose production under fasting conditions in patients with and without T2D. The investigators will also assess how glucagon, a hormone that raises blood glucose levels, impacts the conversion of glycerol and lactate to glucose. Enrolled participants will undergo three separate isotope tracer infusions with serial blood collections for liquid chromatography-mass spectrometry analysis. This research could identify new therapeutic drug targets that can lower blood glucose levels more directly and effectively.

Key Dates

First listed
May 2, 2025
Start date
Jul 1, 2026
Status verified
Nov 2025
Primary completion
Apr 30, 2029
Completion
Apr 30, 2030

Study Design

Enrollment
48 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Glycerol
    Each subject will receive labeled 13C3-glycerol.
  • Experimental: Lactate
    Each subject will receive labeled 13C3-lactate.
  • Experimental: Glucose
    Each subject will receive labeled 13C6-glucose.

Primary Outcome Measure

Carbon Contribution to Glucose Production [ Time Frame: 8 hours ]

Central Contacts

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