Cohort of Patients With Ulcerative Colitis or Polyps Followed in CHU de Bordeaux Associated With a Biocollection - COLIBRI

Sponsor
University Hospital, Bordeaux
Study ID
NCT07082231
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Blood sample — OTHER
    3 blood samples
  • biopsy — PROCEDURE
    3 pairs of biopsy realised during the coloscopy

Study Details

Ulcerative colitis (UC) is a chronic disease characterized by acute episodes of bloody diarrhea with varying degrees of severity. The most feared event, acute severe UC, can lead to life-threatening and systemic complications. Little is known about the determinants of severity in UC. The investigators hypothesize that distinct severity phenotypes of UC arise from intricated host-microbiota mechanisms influencing repair mechanisms. Our first and main objective is to study the natural history of UC during a one-year time period in a cohort of patients.

Key Dates

First listed
Jul 24, 2025
Start date
Sep 30, 2025
Status verified
Jul 2025
Primary completion
Sep 30, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Active Comparator: Ulcerative Colitis Group
  • Placebo Comparator: Non-Ulcerative Colitis with Polyps Group

Primary Outcome Measure

Mayo clinical activity score [ Time Frame: Baseline, Month 12 ]

Central Contacts

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