Ferroptosis Role in the Pathophysiology of Systemic Lupus Erythematosus

Sponsor
University Hospital, Bordeaux
Study ID
NCT07260942
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • blood sample — BIOLOGICAL
    30 ml whole blood for Peripheral blood mononuclear cell (PBMC) and monocytes isolation

Study Details

The study aims at defining the role of ferroptosis s in the physiopathology of systemic lupus erythematosus (SLE). Ferroptosis (phenomenon of cellular death regulated by iron) is a metabolic pathway potentially implicated in SLE with potential for the discovery of new therapeutic strategies.

Key Dates

First listed
Dec 3, 2025
Start date
Apr 21, 2026
Status verified
May 2026
Primary completion
Apr 30, 2029
Completion
Apr 30, 2029

Study Design

Enrollment
120 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Systemic lupus erythematosus (SLE)
  • Active Comparator: Rheumatoid arthritis or an inflammatory bowel

Primary Outcome Measure

Measurement of lipid peroxidation in regulatory T lymphocytes population in lupus subjects. [ Time Frame: At baseline (Day 0) ]

Central Contacts

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