Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.

Sponsor
University of Seville
Study ID
NCT07361887
Status
Recruiting
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Conditions

  • Alzheimer s Disease
  • Atherosclerosis Cardiovascular Disease
  • Inflammation
  • Metabolic Disorders
  • Metabolic Syndrome
  • Neurodegeneration
  • Neurodegenerative Disease
  • Obesity

Eligibility Criteria

Sex
ALL
Age
35 Years - 36 Years
Healthy Volunteers
Accepted

Interventions

  • White Wine — DIETARY_SUPPLEMENT
    Chardonnay, 4 mL/kg body weight
  • Red Wine — DIETARY_SUPPLEMENT
    Cabernet Sauvignon, 4 mL/kg body weight
  • Water — DIETARY_SUPPLEMENT
    Still water, 4 mL/kg body weight

Study Details

This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults. EVs are small particles released by cells that carry proteins, lipids, and genetic material, and play important roles in communication between cells. Participants will consume a single serving of red or white wine, and blood samples will be collected before and after consumption to study changes in the composition and function of EVs. The study will also assess how these EVs affect vascular, immune, and brain-related cells. The results are expected to improve our understanding of how moderate wine intake contributes to cardiovascular and brain health.

Key Dates

First listed
Jan 23, 2026
Start date
Nov 1, 2025
Status verified
Jan 2026
Primary completion
Dec 1, 2025
Completion
Mar 31, 2027

Study Design

Enrollment
8 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Red Wine
    Participants will consume red wine (Cabernet Sauvignon) at a dose of 4 mL per kg body weight within 15 minutes. Blood samples will be collected at fasting (0 h), postprandial peak (1-2 h), and post-peak (6 h).
  • Experimental: White Wine
    Participants will consume white wine (Chardonnay) at a dose of 4 mL per kg body weight within 15 minutes. Blood samples will be collected at fasting (0 h), postprandial peak (1-2 h), and post-peak (6 h).
  • Placebo Comparator: Water (Control)
    Participants will consume water (4 mL per kg body weight) within 15 minutes, serving as the control condition. Blood samples will be collected at fasting (0 h), postprandial peak (1-2 h), and post-peak (6 h).

Primary Outcome Measure

Concentration of circulating extracellular vesicles [ Time Frame: Baseline (0 hours), postprandial peak (2 hours after beverage intake), and post-peak (6 hours after beverage intake). ]

Central Contacts

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