Cognition and Behavior With Sham Accelerated TMS

Conditions

• Depression

Eligibility Criteria

Sex

ALL

Age

15 Years - 25 Years

Healthy Volunteers

Not accepted

Interventions

• Transcranial Magnetic Stimulation Sham — DEVICE
  All study participants will receive sham TMS (no active stimulation will be provided).

Study Details

The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimulation (TMS) treatment. No active brain stimulation is given. The main questions this study aims to answer are: 1. Do expectancy and treatment beliefs change during and after an accelerated sham TMS schedule? 2. Do these expectations influence mood, reward processing, or craving? 3. Does a more intensive schedule of sham sessions lead to different expectancy effects than a slower, once-daily schedule? Participants will: * Complete baseline clinical assessments and an MRI session * Undergo five days of accelerated sham TMS (no active brain stimulation is delivered) * Complete post-treatment MRI and follow-up assessments at 1 week and 4 weeks

Key Dates

Start date

Apr 11, 2026

Status verified

Jun 2026

Primary completion

Aug 31, 2027

Completion

Jan 31, 2028

Study Design

Enrollment

25 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Other: Open label sham
  All study participants will receive sham TMS (no active stimulation will be provided).

Primary Outcome Measure

Accelerated sham TMS feasibility [ Time Frame: From enrollment to end of study at 5 weeks ]

Locations (1)

Find similar trials in Sacramento, CA

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