Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer

Conditions

• Breast Cancer
• Colon Cancer
• Germline BRCA1 Gene Mutation
• Germline BRCA2 Gene Mutation
• Lynch Syndrome
• Pancreas Cancer

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• educational workshop on nutrition + additional intervention on UPF tool and how to use it — BEHAVIORAL
  Participants with WCRF score at baseline ≤ 5 will be randomized at 1:1 ratio between intervention group (educational workshop on nutrition + additional intervention on UPF tool and how to use it) and control group (educational workshop on nutrition only). Impact will be assessed at 12 weeks with the WCRF questionnaire.

Study Details

The U-TRANS study was initiated by Gustave Roussy, which is its sponsor\*. It is part of the Interception Program and aims to reduce the consumption of ultra-processed foods in order to improve the overall quality of the diet among people at high risk of cancer (WCRF score ≤ 5, corresponding to low adherence to nutritional cancer prevention recommendations: eating a diet rich in whole grains, vegetables, fruit and fibre, and limiting ultra-processed foods, red meat, processed meats, sugary drinks and alcohol). It assesses the impact of a digital intervention (based on the use of the Open Food Facts app) as a complement to the nutritional education provided by the Interception program.

Key Dates

First listed

Feb 27, 2026

Start date

May 4, 2026

Status verified

May 2026

Primary completion

Sep 30, 2027

Completion

Mar 31, 2028

Study Design

Enrollment

170 participants (estimated)

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

OTHER

Arms

• Experimental: Intervention group
  The patients will receive an educational workshop on nutrition and an additional intervention on UPF tool and how to use it
• No Intervention: Control group
  The patients will only receive en educational workshop on nutrition

Primary Outcome Measure

Proportion (%) of participants with at least 1-point improvement in the WCRF score [ Time Frame: Week 12 ]

Central Contacts

• Bruno Raynard, MD
  +33 (0) 1 42 11 42 11
  [email protected]
• Adeline Salasc, Pharm D
  +33 (0) 1 42 11 42 11
  [email protected]

Find similar trials

Related Studies

• Collection of Blood From Patients With Cancer
  Recruiting · National Cancer Institute (NCI) · Bethesda, Maryland
• Harvesting Cells for Experimental Cancer Treatments
  Enrolling By Invitation · National Cancer Institute (NCI) · Bethesda, Maryland
• High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast Cancer
  Recruiting · Carol Fabian, MD · Kansas City, Kansas
• Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies
  Recruiting · National Cancer Institute (NCI) · Bethesda, Maryland