CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
EyePoint Pharmaceuticals, Inc.
Study ID
NCT07449923
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Key Dates

First listed
Mar 4, 2026
Start date
Feb 9, 2026
Status verified
Sep 2026
Primary completion
Oct 31, 2027
Completion
Oct 31, 2028

Study Design

Enrollment
240 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: EYP-1901 2686 µg
    EYP-1901
  • Active Comparator: Aflibercept

Primary Outcome Measure

Average change in best corrected visual acuity (BCVA) [ Time Frame: Weeks 52 and 56 ]

Locations (51)

FacilityCityStateZIPSite coordinators
Associated Retina ConsultansGilbertArizona85297-
Associated Retina Consultants - PhoenixPhoenixArizona85020-
Phoenix Retina Clinical Trials, LLC - North PhoenixPhoenixArizona85050-
Retina Macula Institute of ArizonaScottsdaleArizona85255-
Retina Vitreous Associates Medical GroupBeverly HillsCalifornia90211-
Retina Consultants of Orange CountyFullertonCalifornia92835-
South Coast Retina CenterLong BeachCalifornia90807-
Retinal Consultants Medical Group - ModestoModestoCalifornia95356-
Kaiser PermanenteOaklandCalifornia94611-
Retina Consultants of Southern CaliforniaRedlandsCalifornia92374-
Bay Area Retina AssociatesWalnut CreekCalifornia94598-
Retina Specialists of Colorado - ArvadaArvadaColorado80002-
Connecticut Eye Consultants, P.C.DanburyConnecticut06810-
Coastal Eye Surgeons, LLCGreenwichConnecticut06830-
Retina Group of New England, PCWaterfordConnecticut06385-
Retina Group of Florida - Fort LauderdaleFort LauderdaleFlorida33308-
Retina Specialty InstitutePensacolaFlorida32503-
Fort Lauderdale Eye InstitutePlantationFlorida33324-
MedEye AssociatesSouth MiamiFlorida33143-
Retina Vitreous Associates of Florida - Saint PetersburgSt. PetersburgFlorida33711-
Retina Vitreous Associates of FloridaTampaFlorida33617-
Retina AssociatesElmhurstIllinois60126-
University Retina and Macula AssociatesLemontIllinois60439-
Illinois Retina Associates, S.C.Oak ParkIllinois60304-
Associated Vitreoretinal & Uveitis Consultants - CarmelCarmelIndiana46032-
The Eye Care InstituteLouisvilleKentucky40206-
Retina Associates New OrleansMetairieLouisiana70006-
Cumberland Valley Retina ConsultantsHagerstownMaryland21740-
Mid Atlantic Retina Specialists - HagerstownHagerstownMaryland21740-
Vitreo Retinal Associates, PCWorcesterMassachusetts01605-
The Retina InstituteSt LouisMissouri63128-
Retina Center of New JerseyBloomfieldNew Jersey07003-
Vision Research Center at Eye Associates of New MexicoAlbuquerqueNew Mexico87109-
Retina Vitreous Surgeons of CNY, PCLiverpoolNew York13088-
Graystone Eye - Hickory OfficeHickoryNorth Carolina28602-
North Carolina Retina AssociatesWake ForestNorth Carolina27587-
Retina Vitreous Center, PLLCEdmondOklahoma73013-
Verum Research, LLCEugeneOregon97401-
Wills Eye HospitalPhiladelphiaPennsylvania19107-
Carolinas Centers for Sight, P.C. - Florence CampusFlorenceSouth Carolina29501-
Charles Retina InstituteGermantownTennessee38138-
Austin Clinical Research LLCAustinTexas78750-
Retina and Vitreous of TexasBellaireTexas77401-
Retina Consultants of TexasBellaireTexas77401-
Retina Associates of South TexasSan AntonioTexas78240-
San Antonio Eye CenterSan AntonioTexas78215-
Retina Consultants of TexasThe WoodlandsTexas77384-
Tyler Retina ConsultantsTylerTexas75703-
Strategic Clinical Research Group, LLCWillow ParkTexas76087-
The Retina Group of WashingtonFairfaxVirginia22031-
Eye Clinic of WisconsinWausauWisconsin54403-

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Associated Retina Consultans· Gilbert, AZAssociated Retina Consultants - Phoenix· Phoenix, AZPhoenix Retina Clinical Trials, LLC - North Phoenix· Phoenix, AZRetina Macula Institute of Arizona· Scottsdale, AZRetina Vitreous Associates Medical Group· Beverly Hills, CARetina Consultants of Orange County· Fullerton, CA

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