COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

Part of paid clinical trials in Bakersfield, California.

Sponsor
EyePoint Pharmaceuticals, Inc.
Study ID
NCT07449936
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Key Dates

First listed
Mar 4, 2026
Start date
Feb 16, 2026
Status verified
Sep 2026
Primary completion
Oct 31, 2027
Completion
Oct 31, 2028

Study Design

Enrollment
240 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: EYP-1901 2686 µg
    EYP-1901
  • Active Comparator: Aflibercept

Primary Outcome Measure

Average change in best corrected visual acuity (BCVA) [ Time Frame: Weeks 52 and 56 ]

Locations (53)

FacilityCityStateZIPSite coordinators
California Retina ConsultantsBakersfieldCalifornia93309-
The Retina PartnersEncinoCalifornia91436-
Global Research Management, Inc.GlendaleCalifornia91204-
Northern California Retina Vitreous Associates Medical Group INC.Mountain ViewCalifornia94040-
Retina Consultants of San DiegoPowayCalifornia92064-
California Eye Specialists Medical Group, Inc.RedlandsCalifornia92373-
Retinal Consultants Medical GroupSacramentoCalifornia95841-
Retinal Consultants Medical Group - Parkcenter DriveSacramentoCalifornia95825-
Retina Consultants of Southern ColoradoColorado SpringsColorado80909-
Colorado Retina AssociatesLakewoodColorado80228-
Advanced Research LLC Sibia Eye InstituteBoynton BeachFlorida33437-
Advance Medical Research Group, IncDeerfield BeachFlorida33064-
Eye Associates of PinellasPinellas ParkFlorida33782-
Retina Vitreous Associates of Florida - Saint PetersburgSt. PetersburgFlorida33711-
Southern Vitreoretinal AssociatesTallahasseeFlorida32308-
Retina Specialists of TampaWesley ChapelFlorida33544-
Georgia RetinaMariettaGeorgia30060-
Retina Consultants of Hawaii‘AieaHawaii96701-
Red River Research PartnersPlainfieldIllinois60586-
Midwest Eye Institute - CarmelCarmelIndiana11220-
Haik Humble Eye CenterWest MonroeLouisiana71291-
Johns Hopkins Medicine - The Johns Hopkins Hospital Campus - Wilmer Eye InstituteBaltimoreMaryland21287-
Retina Group of WashingtonChevy ChaseMaryland20815-
Cumberland Valley Retina ConsultantsHagerstownMaryland21740-
Retina Specialists - TowsonTowsonMaryland21204-
New England Retina ConsultantsSpringfieldMassachusetts01107-
Retina Associates of MichiganGrand BlancMichigan48439-
Foundation for Vision ResearchGrand RapidsMichigan49546-
Sierra Eye AssociatesRenoNevada89502-
NJRetina Care Center - TeaneckTeaneckNew Jersey07666-
NJ Retina - Toms RiverToms RiverNew Jersey08755-
Retina Associates of Western New YorkRochesterNew York14620-
VRCNY/Long Island Vitreoretinal ConsultantsWestburyNew York11590-
Asheville Eye Associates - Regional Medical ParkAshevilleNorth Carolina28803-
Cape Fear Retinal Associates, PCWilmingtonNorth Carolina28401-
Piedmont Retina Specialists, P.A. - Winston-Salem OfficeWinston-SalemNorth Carolina27103-
Tulsa Retina ConsultantTulsaOklahoma74114-
Erie Retina ResearchEriePennsylvania16507-
Charleston Neuroscience Institute - BeaufortBeaufortSouth Carolina29902-
Retina Consultants of Carolina P.AGreenvilleSouth Carolina29605-
Tennessee RetinaNashvilleTennessee37203-
Retina Research Institute of Texas Integrated Clinical ResearchAbileneTexas79606-
Texas Retina AssociatesDallasTexas75231-
Mt. Olympus Medical ResearchHoustonTexas77479-
Retina Consultants of TexasKatyTexas77494-
Texas Retina AssociatesPlanoTexas75075-
Retina Consultants of TexasSchertzTexas78154-
Tyler Retina ConsultantsTylerTexas75703-
Retina Associates of UtahSalt Lake CityUtah84107-
Salt Lake RetinaWest JordanUtah84088-
Piedmont Eye CenterLynchburgVirginia24502-
Virginia Retina CenterWarrentonVirginia20186-
Northeast Wisconsin Retina AssociatesAppletonWisconsin54914-

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By research site
California Retina Consultants· Bakersfield, CAThe Retina Partners· Encino, CAGlobal Research Management, Inc.· Glendale, CANorthern California Retina Vitreous Associates Medical Group INC.· Mountain View, CARetina Consultants of San Diego· Poway, CACalifornia Eye Specialists Medical Group, Inc.· Redlands, CA

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