Microbiome-targeted Diet Therapy in Ulcerative Colitis

Sponsor
University of Minnesota
Study ID
NCT07520461
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • High Protein, High Fiber (HPHF) Diet — OTHER
    The HPHF diet is a diet designed to maximize the intake of proteins and fermentable dietary fibers. Frozen meals are provided to participants weekly and consumed over two non-consecutive 7-day periods.

Study Details

The central objective of this proposal is to test a novel diet capable of meeting the elevated protein requirements in ulcerative colitis (UC), while simultaneously decreasing microbial hydrogen sulfide (H2S) production in the colon with fiber.

Key Dates

First listed
Apr 9, 2026
Start date
Aug 1, 2026
Status verified
Jul 2026
Primary completion
Jun 1, 2029
Completion
Jun 1, 2029

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: On-Off Cycling Intervention
    1 week standard diet, followed by 1 week high-protein, high-fiber diet, followed by 1 week standard diet, followed by 1 week high-protein, high-fiber diet

Primary Outcome Measure

Fecal H2S Production [ Time Frame: Week 4 ]

Central Contacts

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