Comprehensive Rehabilitation Programme in People With Multiple Sclerosis: The RECONNECT-MS Study

Sponsor
Charles University, Czech Republic
Study ID
NCT07666958
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Individual Physiotherapy — BEHAVIORAL
    Facilitation-based individual physiotherapy (Motor Programme Activating Therapy, Dynamic Neuromuscular Stabilisation, soft-tissue and mobilisation techniques). 50 minute sessions, twice weekly for 8 weeks, then 3 maintenance sessions at progressively extended intervals during weeks 9-12. Delivered by two alternating physiotherapists.
  • Group Movement Awareness — BEHAVIORAL
    Three small-group sessions (6-8 participants) of Feldenkrais Awareness Through Movement (ATM).
  • Group Psychotherapy — BEHAVIORAL
    Three 60-minute small-group sessions focused on stress management, emotion regulation, relaxation techniques, and psychoeducation.
  • Nutritional Recommendations — OTHER
    Written / online evidence-based nutritional recommendations for autoimmune disease.

Study Details

The goal of this clinical trial is to learn if a comprehensive rehabilitation programme can improve physical function, reduce fatigue, and raise quality of life in adults aged 18-65 with multiple sclerosis (MS). The study will also look at whether the programme leads to changes in brain function using magnetic resonance imaging (MRI). The main questions it aims to answer are: * Does the programme lower the overall impact of MS on daily life? * Does the programme improve walking, balance, and hand function? * Does the programme reduce the impact of fatigue? * Are there changes in brain connections after the programme? Each participant serves as their own comparison. They are tested 3 times: 2 months before the programme starts (T0), right before it starts (T1), and after 2 months of intensive treatment (T2). The period between T0 and T1, when no treatment is given, shows each person's natural changes over time. Participants will: * Attend individual physiotherapy twice a week for 2 months, then 3 follow-up sessions over the next month * Take part in 3 group movement-awareness sessions * Take part in 3 group psychotherapy sessions focused on stress management and relaxation * Receive written nutritional guidance for autoimmune conditions Tests include physical assessments, questionnaires about fatigue and quality of life, tremor measurement, and brain MRI scans. The results may help improve rehabilitation care for people with MS and support their ability to stay active in everyday and working life.

Key Dates

First listed
Jun 24, 2026
Start date
Jul 1, 2026
Status verified
Jun 2026
Primary completion
Feb 28, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
45 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Comprehensive Rehabilitation Programme
    Participants receive a 3-month multidisciplinary rehabilitation programme combining individual physiotherapy (twice weekly for 2 months, followed by 3 maintenance sessions over the 3rd month), 3 group movement-awareness sessions (Feldenkrais ATM), 3 group psychotherapy sessions, and written nutritional recommendations.

Primary Outcome Measure

Change in MS-specific health impact (Multiple Sclerosis Impact Scale, MSIS-29 total score) [ Time Frame: Change from baseline (T1, immediately before intervention start) to T2 (2-month intensive intervention phase) ]

Central Contacts

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