Multiple sclerosis Clinical Trials

Recruiting multiple sclerosis studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat multiple sclerosis. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting multiple sclerosis studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting multiple sclerosis trials

Within

Exercise With and Without Cognitive Training

for Multiple Sclerosis

1 site in Decatur

Sponsor: VA Office of Research and Development

Sex: All·Age: 55 - 85

Code: NCT07447115

Lead Exposure and Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Assiut University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07423312

Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Tianjin Medical University General Hospital

Sex: All·Age: 18 - 60

Code: NCT06228781

Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care

for Multiple Sclerosis

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT06386133

A Biosimilar Trial to Investigate PK, PD, Safety With PB018 Versus US-licensed Ocrevus and EU-approved Ocrevus

for Multiple Sclerosis

Sponsor: Polpharma Biologics International AG

Sex: All·Age: 18 - 65

Code: NCT07606521·Phase 1

Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hunter College of City University of New York

Sex: All·Age: 18+

Code: NCT07552428

OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis

for Multiple Sclerosis

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 65

Code: NCT07221799·Phase 1

Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project

for Multiple Sclerosis

1 site in Boca Raton

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT07472413·Phase 3

Multicenter Prospective Study Analyzing the Occurrence of Multiple Sclerosis Relapses Without Radiological Evidence: Myth or Reality?

for Multiple Sclerosis

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18 - 70

Code: NCT07545889

Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Sharjah

Sex: All·Age: 18+

Code: NCT07555379

My MS Toolkit: An Internet-Based Depression Self-Management Program for Adults Living With Multiple Sclerosis

for Multiple Sclerosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07636434

Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool

for Optic Neuritis

Sponsor: King's College London

Sex: All·Age: 16+

Code: NCT07704294

Emerging Indications for Hyperbaric Oxygen Treatment

for Post-COVID-19 Condition

Sponsor: Jay C. Buckey Jr.

Sex: All·Age: All ages

Code: NCT07240649·Phase 4

Inspiratory Muscle Training in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18 - 65

Code: NCT07672535

FES: Effect on Walking in the Real World and Participation in Daily Life in People With Multiple Sclerosis.

for Multiple Sclerosis

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 22 - 75

Code: NCT07706114

A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy

for Multiple Sclerosis

10 sites incl. Birmingham

Sponsor: Genentech, Inc.

Sex: All·Age: 18 - 65

Code: NCT07609719·Phase 4

Simultaneous T2-FLAIR and T1 Brain MRI With ENRAGED FLAIR in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Region Stockholm

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07687693

Augmented Reality-Based Dual-Task Training in People With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Sharjah

Sex: All·Age: 18+

Code: NCT07434934

Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

for Multiple Sclerosis

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 64

Code: NCT07475377

An Online Nurse-Led Purpose-Focused Group Program for Adult Women With Multiple Sclerosis: Effects on Meaning and Quality of Life

for Multiple Sclerosis

1 site in Denton

Sponsor: Texas Woman's University

Sex: Female·Age: 18+

Code: NCT07555015

Apply to this trial

The Effects of High-Intensity Interval Training on Gait, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hacettepe University

Sex: All·Age: 18+

Code: NCT07578740

Home-based Spinal Cord Stimulation for Hand & Arm Function in MS

for Multiple Sclerosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18 - 70

Code: NCT07673354

Effects Of Motor Imagery and Sensorimotor Training

for Multiple Sclerosis

Sponsor: Uludag University

Sex: All·Age: 18 - 45

Code: NCT07710742

A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University Hospital, Antwerp

Sex: All·Age: 18 - 65

Code: NCT07020715·Phase 2

Using Motor Imagery-based Brain-computer Interface With Multiple Sclerosis Patients.

for Multiple Sclerosis

Sponsor: Pasquale Arpaia

Sex: All·Age: 18 - 60

Code: NCT07472556

Single Arm Trial Identifying Barriers and Facilitators to Mindfulness Practice

for Multiple Sclerosis

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07573241

Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis

for Multiple Sclerosis

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 18+

Code: NCT07606742

Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS

for Multiple Sclerosis

Sponsor: University of Saskatchewan

Sex: All·Age: 18+

Code: NCT07631143·Phase 1, Phase 2

Comprehensive Rehabilitation Programme in People With Multiple Sclerosis: The RECONNECT-MS Study

for Multiple Sclerosis

Sponsor: Charles University, Czech Republic

Sex: All·Age: 18 - 65

Code: NCT07666958

The Mediating Role of Balance in the Relationship Between Fatigue and Fear of Falling in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Uskudar University

Sex: All·Age: 18 - 75

Code: NCT07680049

Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis

for Multiple Sclerosis

1 site in New Orleans

Sponsor: Tulane University

Sex: Male·Age: 18+

Code: NCT04601233·Phase 4

A Study to Evaluate MTM-H-001 Injection in Adult Patients With B-Cell-Related Autoimmune Diseases

for Systemic Lupus Erthematosus (SLE)

Sponsor: Beijing GoBroad Hospital

Sex: All·Age: 18 - 75

Code: NCT07593911

Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients

for Post-stroke

Sponsor: Marta Mondellini

Sex: All·Age: 18+

Code: NCT07616050

Switch to Ofatumumab and Level of Immunoglobulins

for Multiple Sclerosis

Sponsor: University Hospital, Lille

Sex: All·Age: 18 - 65

Code: NCT07625800

Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD

for Spinal Cord Injury

2 sites incl. Washington D.C.

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07643974·EARLY_Phase 1

Effect of High-Intensity Focused Electromagnetic Therapy on Balance and Quality of Life in Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Middle East University

Sex: All·Age: 18 - 60

Code: NCT07646912

Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Calgary

Sex: All·Age: 18 - 65

Code: NCT07562074·Phase 1

Acute Intermittent Hypoxia Combined With Gait Training in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT07631923

Ocrevus Zunovo for MS: Mixed Methods

for Multiple Sclerosis

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07710105

Apply to this trial

MS and Health Cohort

for Multiple Sclerosis

Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Sex: All·Age: 18+

Code: NCT07645703

Hyperpolarized Carbon Metabolic Imaging in Multiple Sclerosis

for Multiple Sclerosis

1 site in San Francisco

Sponsor: Ari Green

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07510607·Phase 2

Apply to this trial

The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07504120

EFFECTS OF AEROBIC AND RESISTANCE TRAINING ON IMMUNE FUNCTION IN MULTIPLE SCLEROSIS

for Multiple Sclerosis

Sponsor: Seda Saka

Sex: All·Age: 19 - 45·Accepts healthy volunteers

Code: NCT07640100

An Open-Label, Single-Arm Clinical Study to Evaluate the Safety and Preliminary Efficacy of CD20 Monoclonal Antibody Combined With NK042 Cell Injection in the Treatment of Multiple Sclerosis (MS).

for Multiple Sclerosis

Sponsor: The Affiliated Hospital of Xuzhou Medical University

Sex: All·Age: 18 - 65

Code: NCT07546110·EARLY_Phase 1

Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study

for Multiple Sclerosis

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07560995

Safety and Efficacy of S103 Cells in Progressive/Refractory Multiple Sclerosis

for Multiple Sclerosis (MS) Primary Progressive

Sponsor: Xijing Hospital

Sex: All·Age: 18 - 75

Code: NCT07587125·Phase 1

Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis: Case-control Study

for Multiple Sclerosis

Sponsor: University of Catania

Sex: Female·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06020937

Development of Pain Management JITAI Content in Multiple Sclerosis and Spinal Cord Injury

for Multiple Sclerosis

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07663266

Apply to this trial

Auditory Functions in Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Catania

Sex: All·Age: 20 - 40·Accepts healthy volunteers

Code: NCT06164483

Apply to this trial

Dry Needling in Multiple Sclerosis

for Multiple Sclerosis

1 site in Tampa

Sponsor: University of South Florida

Sex: All·Age: 18 - 80

Code: NCT07615725

Apply to this trial

ATLG Levels in Autologous HSCT for Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Ciceri Fabio

Sex: All·Age: 18+

Code: NCT07635693

Apply to this trial

VR-based Dexterity Training in MS

for Multiple Sclerosis

Sponsor: Christian Kamm

Sex: All·Age: 18 - 75

Code: NCT07193602

Impact of Exercise Training on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Firat University

Sex: All·Age: 18 - 65

Code: NCT07521995

Effects of Sleep Quality on Functional and Cognitive Outcomes in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Büşra Seçkinoğulları Korkusuz

Sex: All·Age: 18 - 65

Code: NCT07536503

Apply to this trial

Exercise Training for People With Advanced Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Ottawa

Sex: All·Age: 18+

Code: NCT07546721

Relationship Between Cognition, Workforce Participation and Well-Being in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Region Gävleborg

Sex: All·Age: 18 - 65

Code: NCT07211516

Home-Based Exergame Rehabilitation for Upper Limb Function in People With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Marina Castel Sánchez

Sex: All·Age: 18+

Code: NCT07430462

Silodosin for Urinary Symptoms in Female Patients With Multiple Sclerosis

for Multiple Sclerosis

1 site in Morristown

Sponsor: Atlantic Health System

Sex: Female·Age: 18+

Code: NCT07614321·Phase 4

Apply to this trial

Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis

for Multiple Sclerosis

2 sites incl. Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 60

Code: NCT07497399·Phase 2

Apply to this trial

Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS

for Multiple Sclerosis

Sponsor: Ondokuz Mayıs University

Sex: All·Age: 18 - 60

Code: NCT07535242

Multiple sclerosis clinical trials — common questions

Are multiple sclerosis clinical trials free to join?

Yes. Participating in a multiple sclerosis clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a multiple sclerosis clinical trial?

Each multiple sclerosis study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a multiple sclerosis trial near me?

Use the location controls above. We'll show recruiting multiple sclerosis trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many multiple sclerosis trials are recruiting right now?

We're currently tracking roughly 147 recruiting multiple sclerosis trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Multiple sclerosis trials by city

Chicago, IL Boston, MA Birmingham, AL San Francisco, CA Aurora, CO Seattle, WA La Jolla, CA Los Angeles, CA Ann Arbor, MI Miami, FL Palo Alto, CA Sacramento, CA

Related specialties

Neurology Brain disorders Autoimmune disease