Multiple sclerosis Clinical Trials

Recruiting multiple sclerosis studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat multiple sclerosis. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting multiple sclerosis studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting multiple sclerosis trials

Within

Exercise With and Without Cognitive Training

for Multiple Sclerosis

1 site in Decatur

Sponsor: VA Office of Research and Development

Sex: All·Age: 55 - 85

Code: NCT07447115

Lead Exposure and Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Assiut University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07423312

Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Tianjin Medical University General Hospital

Sex: All·Age: 18 - 60

Code: NCT06228781

Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care

for Multiple Sclerosis

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT06386133

A Biosimilar Trial to Investigate PK, PD, Safety With PB018 Versus US-licensed Ocrevus and EU-approved Ocrevus

for Multiple Sclerosis

Sponsor: Polpharma Biologics International AG

Sex: All·Age: 18 - 65

Code: NCT07606521·Phase 1

Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hunter College of City University of New York

Sex: All·Age: 18+

Code: NCT07552428

Physical Activity Intervention for Individuals Newly Diagnosed With MS

for Multiple Sclerosis

1 site in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07731659

Cone Evasion Walk Test in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hacettepe University

Sex: All·Age: 18 - 70

Code: NCT07786987

Evaluating the Use of Oral Indapamide to Reduce Disabiltiy Progression in Progressive Multiple Sclerosis (MS)

for Multiple Sclerosis

Sponsor: Eva M.M. Strijbis

Sex: All·Age: 18 - 65

Code: NCT07765212·Phase 2

Phase Ib/II Study of SYS6020 in Relapsing/Refractory Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Tongji Hospital

Sex: All·Age: 18 - 65

Code: NCT07756268·Phase 1, Phase 2

PLasmatic Extracellular Vesicles AS Biomarkers of nEural Tissue Damage

for Multiple Sclerosis

Sponsor: Roberto Furlan

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07769294

Effects of Face-to-Face Versus Telerehabilitation-Based Circuit Training in People With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18 - 65

Code: NCT07770620

Effectiveness of a Mindfulness-Based Intervention for Pain Management in Patients With Multiple Sclerosis (MPIMS).

for Multiple Sclerosis

Sponsor: Hospital Universitario Virgen Macarena

Sex: All·Age: 18 - 80

Code: NCT07741864

OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis

for Multiple Sclerosis

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 65

Code: NCT07221799·Phase 1

Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project

for Multiple Sclerosis

1 site in Boca Raton

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT07472413·Phase 3

Multicenter Prospective Study Analyzing the Occurrence of Multiple Sclerosis Relapses Without Radiological Evidence: Myth or Reality?

for Multiple Sclerosis

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18 - 70

Code: NCT07545889

Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Sharjah

Sex: All·Age: 18+

Code: NCT07555379

Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis

for Multiple Sclerosis

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 18+

Code: NCT07606742

Apply to this trial

My MS Toolkit: An Internet-Based Depression Self-Management Program for Adults Living With Multiple Sclerosis

for Multiple Sclerosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07636434

Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool

for Optic Neuritis

Sponsor: King's College London

Sex: All·Age: 16+

Code: NCT07704294

Sociocognitive Intervention and Rehabilitation Program in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Sonia Batista

Sex: All·Age: 18 - 55

Code: NCT07734675

Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Assiut University

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07762040

Emerging Indications for Hyperbaric Oxygen Treatment

for Post-COVID-19 Condition

Sponsor: Jay C. Buckey Jr.

Sex: All·Age: All ages

Code: NCT07240649·Phase 4

Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD

for Spinal Cord Injury

2 sites incl. Washington D.C.

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07643974·EARLY_Phase 1

Inspiratory Muscle Training in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18 - 65

Code: NCT07672535

FES: Effect on Walking in the Real World and Participation in Daily Life in People With Multiple Sclerosis.

for Multiple Sclerosis

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 22 - 75

Code: NCT07706114

Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study

for Multiple Sclerosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 50 - 70

Code: NCT07723599

Online Mindfulness-Based Cognitive Therapy for People With Multiple Sclerosis With Mild-Moderate Depression

for Multiple Sclerosis

Sponsor: Robert Simpson

Sex: All·Age: 18+

Code: NCT07742579·Phase 3

The Role of the FCRL5 Protein in the Pathophysiology of Multiple Sclerosis and Response to Treatment

for Multiple Sclerosis

Sponsor: Université Catholique de Louvain

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07788573

Effect of Artificial Intelligence Based Cognitive Training on Sleep Disorders and Quality of Life in Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Cairo University

Sex: All·Age: 25 - 40

Code: NCT07762326

A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy

for Multiple Sclerosis

Sponsor: Genentech, Inc.

Sex: All·Age: 18 - 65

Code: NCT07609719·Phase 4

Apply to this trial

Pain Phenotypes in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Kutahya Health Sciences University

Sex: All·Age: 18+

Code: NCT07766213

Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study

for Multiple Sclerosis

1 site in Austin

Sponsor: University of Texas at Austin

Sex: All·Age: 18 - 80

Code: NCT07759115

Apply to this trial

Intermittent Theta-Burst Stimulation for Lower-Limb Spasticity and Pain in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Comenius University

Sex: All·Age: 18+

Code: NCT07786506

Augmented Reality-Based Dual-Task Training in People With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Sharjah

Sex: All·Age: 18+

Code: NCT07434934

Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

for Multiple Sclerosis

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 64

Code: NCT07475377

The Effects of High-Intensity Interval Training on Gait, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hacettepe University

Sex: All·Age: 18+

Code: NCT07578740

Single Arm Trial Identifying Barriers and Facilitators to Mindfulness Practice

for Multiple Sclerosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07573241

Apply to this trial

Home-based Spinal Cord Stimulation for Hand & Arm Function in MS

for Multiple Sclerosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18 - 70

Code: NCT07673354

Effects Of Motor Imagery and Sensorimotor Training

for Multiple Sclerosis

Sponsor: Uludag University

Sex: All·Age: 18 - 45

Code: NCT07710742

A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University Hospital, Antwerp

Sex: All·Age: 18 - 65

Code: NCT07020715·Phase 2

Using Motor Imagery-based Brain-computer Interface With Multiple Sclerosis Patients.

for Multiple Sclerosis

Sponsor: Pasquale Arpaia

Sex: All·Age: 18 - 60

Code: NCT07472556

Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS

for Multiple Sclerosis

Sponsor: University of Saskatchewan

Sex: All·Age: 18+

Code: NCT07631143·Phase 1, Phase 2

Comprehensive Rehabilitation Programme in People With Multiple Sclerosis: The RECONNECT-MS Study

for Multiple Sclerosis

Sponsor: Charles University, Czech Republic

Sex: All·Age: 18 - 65

Code: NCT07666958

The Mediating Role of Balance in the Relationship Between Fatigue and Fear of Falling in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Uskudar University

Sex: All·Age: 18 - 75

Code: NCT07680049

Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis

for Multiple Sclerosis

1 site in New Orleans

Sponsor: Tulane University

Sex: Male·Age: 18+

Code: NCT04601233·Phase 4

A Study to Evaluate MTM-H-001 Injection in Adult Patients With B-Cell-Related Autoimmune Diseases

for Systemic Lupus Erthematosus (SLE)

Sponsor: Beijing GoBroad Hospital

Sex: All·Age: 18 - 75

Code: NCT07593911

Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients

for Post-stroke

Sponsor: Marta Mondellini

Sex: All·Age: 18+

Code: NCT07616050

Switch to Ofatumumab and Level of Immunoglobulins

for Multiple Sclerosis

Sponsor: University Hospital, Lille

Sex: All·Age: 18 - 65

Code: NCT07625800

Effect of High-Intensity Focused Electromagnetic Therapy on Balance and Quality of Life in Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Middle East University

Sex: All·Age: 18 - 60

Code: NCT07646912

Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Calgary

Sex: All·Age: 18 - 65

Code: NCT07562074·Phase 1

Acute Intermittent Hypoxia Combined With Gait Training in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT07631923

Ocrevus Zunovo for MS: Mixed Methods

for Multiple Sclerosis

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07710105

Apply to this trial

MS and Health Cohort

for Multiple Sclerosis

Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Sex: All·Age: 18+

Code: NCT07645703

Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia

for Multiple Sclerosis

1 site in Lawrenceville

Sponsor: Bristol-Myers Squibb

Sex: All·Age: All ages

Code: NCT07732907

Apply to this trial

Hyperpolarized Carbon Metabolic Imaging in Multiple Sclerosis

for Multiple Sclerosis

1 site in San Francisco

Sponsor: Ari Green

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07510607·Phase 2

Apply to this trial

The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07504120

EFFECTS OF AEROBIC AND RESISTANCE TRAINING ON IMMUNE FUNCTION IN MULTIPLE SCLEROSIS

for Multiple Sclerosis

Sponsor: Seda Saka

Sex: All·Age: 19 - 45·Accepts healthy volunteers

Code: NCT07640100

An Open-Label, Single-Arm Clinical Study to Evaluate the Safety and Preliminary Efficacy of CD20 Monoclonal Antibody Combined With NK042 Cell Injection in the Treatment of Multiple Sclerosis (MS).

for Multiple Sclerosis

Sponsor: The Affiliated Hospital of Xuzhou Medical University

Sex: All·Age: 18 - 65

Code: NCT07546110·EARLY_Phase 1

Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study

for Multiple Sclerosis

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07560995

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Multiple sclerosis clinical trials — common questions

Are multiple sclerosis clinical trials free to join?

Yes. Participating in a multiple sclerosis clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a multiple sclerosis clinical trial?

Each multiple sclerosis study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a multiple sclerosis trial near me?

Use the location controls above. We'll show recruiting multiple sclerosis trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many multiple sclerosis trials are recruiting right now?

We're currently tracking roughly 147 recruiting multiple sclerosis trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Multiple sclerosis trials by city

Chicago, IL Boston, MA Birmingham, AL San Francisco, CA Seattle, WA Aurora, CO Cleveland, OH La Jolla, CA Los Angeles, CA Miami, FL Sacramento, CA

Related specialties

Neurology Brain disorders Autoimmune disease