Free Fatty Acid Effects In Type 2 Diabetes

Sponsor
University of Ulster
Study ID
NCT07677995
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Omega-3 Fatty Acids — DIETARY_SUPPLEMENT
    1500mg/day for 28 days
  • Semaglutide 0.25 mg — DRUG
    0.25mg weekly for four weeks
  • Placebo — DIETARY_SUPPLEMENT
    Receive placebo

Study Details

Omega-3 fatty acids are natural fats found in foods such as oily fish and flaxseed. Omega-3 fatty acids have been found to have positive effects on cardiovascular health, but there is less evidence on if they can help manage blood glucose in individuals with both cardiovascular disease and type 2 diabetes. This study will investigate whether the beneficial effects found in omega-3 fatty acids such as lowered blood glucose and reduced inflammation - both of which are important for managing type 2 diabetes and cardiovascular disease, can be beneficial for individuals with type 2 diabetes. As omega-3 fatty acids are already found naturally in food, and are already available as supplements, they could be a safe option to help manage these diseases. The aim of this study is to investigate if omega-3 fatty acids can slow down the progression of type 2 diabetes and reduce the risk of cardiovascular disease in individuals with type 2 diabetes.

Key Dates

First listed
Jul 1, 2026
Start date
Jul 31, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Feb 28, 2027

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Placebo
  • Experimental: Omega-3 Fatty Acid Supplementation (EPA/DHA)
  • Experimental: Omega-3 Fatty Acid Supplementation (ALA)
  • Experimental: Omega-3 Fatty Acid Supplementation (EPA/DHA) and Semaglutide
    Semaglutide is being used for comparison purposes only

Primary Outcome Measure

To evaluate the change in fasting glucose from baseline after 28 days of treatment, compared to each treatment group and placebo. [ Time Frame: From baseline to 28 days of treatment ]

Find similar trials

Nationwide
Type 2 diabetes trialsEndocrinology trialsMetabolic health trialsWeight loss trials

Related Studies