Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy

Sponsor
Second Affiliated Hospital of Xi'an Jiaotong University
Study ID
NCT07704203
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Three-Dimensional Magnetic Resonance Elastography — DEVICE
    Patients scheduled for hepatectomy will undergo a preoperative three-dimensional magnetic resonance elastography (3D-MRE) examination in addition to standard-of-care evaluation. 3D-MRE will be used to quantify regional hepatic stiffness and viscoelastic parameters (including shear stiffness, storage modulus, loss modulus, and damping ratio) across different liver segments, with particular attention to the future liver remnant. These parameters will be analyzed for their association with postoperative liver function and the occurrence of post-hepatectomy liver failure. The examination does not alter the standard surgical decision-making process.

Study Details

How to accurately and safely evaluate regional liver function before hepatectomy remains an important unsolved problem in the surgical management of hepatocellular carcinoma (HCC). We plan to develop a non-invasive, functional 3D-MRE-based method for preoperative regional hepatic functional reserve assessment, and to evaluate its ability to predict surgical risk and postoperative liver failure in patients with HCC undergoing hepatectomy.

Key Dates

First listed
Jul 15, 2026
Start date
Aug 1, 2026
Status verified
Jul 2026
Primary completion
Oct 1, 2029
Completion
Oct 1, 2030

Study Design

Enrollment
150 participants (estimated)

Primary Outcome Measure

Incidence of Post-Hepatectomy Liver Failure (PHLF) [ Time Frame: Within 90 days after surgery ]

Central Contacts

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