Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool

Sponsor
King's College London
Study ID
NCT07704294
Status
Not Yet Recruiting

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Conditions

  • Multiple Sclerosis
  • Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders
  • Neuromyelitis Optica Spectrum Disorder
  • Optic Neuritis
  • Sarcoid

Eligibility Criteria

Sex
ALL
Age
16 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • No Intervention: Observational Cohort — OTHER
    Not applicable - No intervention as this is an observation study

Study Details

The goal of this observational study is to determine whether genetic information, together with clinical information, can be used to improve prediction of future multiple sclerosis (MS) diagnosis after a first-time episode of optic neuritis. The study will also investigate visual outcomes, quality of life, healthcare use, and the acceptability of using genetic information to predict future health outcomes in people with optic neuritis. The main outcomes that we aim to assess are: 1. Incident diagnosis of MS following a first episode of optic neuritis, including time to MS diagnosis. 2. Visual outcomes following optic neuritis, including visual acuity, visual field, and colour vision. 3. Clinical care received following optic neuritis, including specialist review, investigations/tests 4. Health-related and vision-related quality of life. 5. Health economic impacts and healthcare utilisation after experiencing optic neuritis 6. Knowledge, attitudes, and practices/behaviours about using genetic information to predict future MS disease risk. If consented, participants will: 1. Allow researchers to review information from their medical records relating to their optic neuritis diagnosis, investigations, treatments, and outcomes. 2. Be invited to provide a saliva sample for genetic analysis. 3. Complete questionnaires about their lifestyle/risk factors, quality of life, and views on genetic risk prediction. 4. Allow researchers to track long-term health outcomes using information from their NHS records

Key Dates

First listed
Jul 15, 2026
Start date
Sep 1, 2026
Status verified
Jun 2026
Primary completion
Dec 1, 2027
Completion
Dec 1, 2027

Study Design

Enrollment
180 participants (estimated)

Arms

  • Arm: Participants Who Have Experienced Optic Neuritis
    Participants with a history of a first episode of optic neuritis recruited from the 3 participating NHS hospitals. Participants will undergo retrospective review of clinical records, complete questionnaires, and may provide a saliva sample for genetic analysis. Participants will be invited to consent to longer term prospective outcome assessment.

Primary Outcome Measure

Incident Multiple Sclerosis Diagnosis Following a First Episode of Optic Neuritis [ Time Frame: Extracted from retrospective record at baseline, and reviewed before study end to capture any new events occurring during the 12 month study period. ]

Central Contacts

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