A Trial to Assess Bioavailability of AMG 133 in Participants With Overweight or Obesity

Part of paid clinical trials in Anaheim, California.

Sponsor
Amgen
Study ID
NCT07717814
Phase
PHASE1
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • AMG 133 (frozen liquid) — DRUG
    AMG 133 will be administered as a SC injection.
  • AMG 133 (liquid) — DRUG
    AMG 133 will be administered as a SC injection.

Study Details

The primary objective of the trial is to evaluate the pharmacokinetics (PK) of AMG 133 administered as a single subcutaneous (SC) dose using a liquid drug product in vial compared to a frozen liquid drug product in vial in participants living with overweight or obesity.

Key Dates

First listed
Jul 21, 2026
Start date
Nov 26, 2024
Status verified
Jul 2026
Primary completion
May 22, 2025
Completion
Jun 2, 2025

Study Design

Enrollment
154 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Group 1 (reference): AMG 133 Concentration A (frozen liquid)
    Participants will receive a single dose of AMG 133 as a SC injection.
  • Experimental: Group 2 (test): AMG 133 Concentration B (liquid)
    Participants will receive a single dose of AMG 133 as a SC injection.
  • Experimental: Group 3 (test): AMG 133 Concentration C (liquid)
    Participants will receive a single dose of AMG 133 as a SC injection.

Primary Outcome Measure

Maximum Observed Concentration (Cmax) of AMG 133 [ Time Frame: Up to Day 120 ]

Locations (4)

FacilityCityStateZIPSite coordinators
Anaheim Clinical TrialsAnaheimCalifornia92801-
Fortrea Clinical Research Unit - Daytona BeachDaytona BeachFlorida32117-5116-
Fortrea Clinical Research Unit - DallasDallasTexas75247-
Fortrea Clinical Research Unit Inc. - MadisonMadisonWisconsin53704-

Find similar trials in Anaheim, CA

Nationwide
Obesity / overweight trialsEndocrinology trialsMetabolic health trialsWeight loss trials
By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Anaheim Clinical Trials· Anaheim, CAFortrea Clinical Research Unit - Daytona Beach· Daytona Beach, FLFortrea Clinical Research Unit - Dallas· Dallas, TXFortrea Clinical Research Unit Inc. - Madison· Madison, WI

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