AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

Part of paid clinical trials in Anniston, Alabama.

Sponsor
Novo Nordisk A/S
Study ID
NCT07720271
Phase
PHASE3
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • zenagamtide — DRUG
    zenagamtide will be taken orally.
  • Placebo — DRUG
    Placebo matched to zenagamtide will be taken orally.

Study Details

The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Key Dates

First listed
Jul 22, 2026
Start date
Sep 1, 2026
Status verified
Jul 2026
Primary completion
Jun 27, 2028
Completion
Aug 22, 2028

Study Design

Enrollment
950 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: zenagamtide
    Participants will be randomized to receive 1 of the 5 dose levels of zenagamtide orally once daily as an adjunct to a reduced-calorie diet and increased physical activity.
  • Placebo Comparator: Placebo
    Participants will receive placebo matched to zenagamtide orally once daily as an adjunct to a reduced-calorie diet and increased physical activity.

Primary Outcome Measure

Relative change in body weight [ Time Frame: From baseline (week 0) to (week 76) ]

Central Contacts

Locations (42)

FacilityCityStateZIPSite coordinators
Pinnacle Research Group LLCAnnistonAlabama36207-
Univ of Alabama BirminghamBirminghamAlabama35294-
Chambliss Clinical Trials LLCMontgomeryAlabama36106-
Providence Medical FoundationFullertonCalifornia92835-
Torrance Clinical Research Institute, Inc.LomitaCalifornia90717-
Diablo Clinical Research, Inc.Walnut CreekCalifornia94598-
Univ of Colorado at DenverAuroraColorado80045-
ERG Holding Company, LLC / Evolution Research Group, LLCDelray BeachFlorida33445-
Northeast Research InstituteFleming IslandFlorida32003-
Miguel Rebollar PAHialeahFlorida33012-
Jacksonville Ctr Clin ResJacksonvilleFlorida32216-
South Broward Research LLCMiramarFlorida33027-
Clinical Neuroscience SolutionOrlandoFlorida32801-
Florida Institute for Clinical Research, LLCOrlandoFlorida32825-
Oviedo Medical Research, LLCOviedoFlorida32765-
Hope Clin Res & WellnessConyersGeorgia30094-
East West Medical Research Institute_HonoluluHonoluluHawaii96814-
Great Lakes Clinical TrialsChicagoIllinois60640-
Clinical Investigation Spec GurneeGurneeIllinois60031-
Endeavor HealthSkokieIllinois60077-
Evanston Premier Hlthcr ResSkokieIllinois60077-
Midwest Inst For Clin ResIndianapolisIndiana46260-
Northern Pines Hlth Ctr, PCBuckleyMichigan49620-
StudyMetrix Research LLCCity of Saint PetersMissouri63303-
Palm Research Center Inc.Las VegasNevada89128-
Comprehensive Weight Ctrl ProgNew YorkNew York10021-
UNC Eastowne Medical OfficeChapel HillNorth Carolina27514-
Medication Mgmnt, LLC_GrnsboroGreensboroNorth Carolina27405-
Accellacare of RaleighRaleighNorth Carolina27609-
Accellacare-Salisbury PMG ResSalisburyNorth Carolina28144-
Accellacare and KDCILM, LLCWilmingtonNorth Carolina28401-
Lynn Institute of NormanNormanOklahoma73072-
Clinical Res CollaborativeCumberlandRhode Island02864-
Medical Uni of SC CharlestonCharlestonSouth Carolina29425-
Coastal Carolina Research CtrNorth CharlestonSouth Carolina29405-
Hillcrest Clinical ResearchSimpsonvilleSouth Carolina29681-1538-
Spartanburg Medical ResearchSpartanburgSouth Carolina29303-
Amarillo Medical SpecialistsAmarilloTexas79124-
North Texas Endocrine CenterDallasTexas75231-
Washington Cntr Weight MgmtArlingtonVirginia22206-
Health Res of Hampton RoadsNewport NewsVirginia23606-
National Clin Res Inc.RichmondVirginia23294-

Find similar trials in Anniston, AL

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Pinnacle Research Group LLC· Anniston, ALUniv of Alabama Birmingham· Birmingham, ALChambliss Clinical Trials LLC· Montgomery, ALProvidence Medical Foundation· Fullerton, CATorrance Clinical Research Institute, Inc.· Lomita, CADiablo Clinical Research, Inc.· Walnut Creek, CA

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