Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study

Part of paid clinical trials in Seattle, Washington.

Sponsor
University of Washington
Study ID
NCT07723599
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Observation — OTHER
    No intervention is administered. Participants undergo observational assessments including MRI, wearable activity monitoring, and questionnaires.

Study Details

This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults with multiple sclerosis (MS). Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time.

Key Dates

First listed
Jul 23, 2026
Start date
Aug 31, 2026
Status verified
Jul 2026
Primary completion
Jun 30, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
14 participants (estimated)

Arms

  • Arm: Adults With Multiple Sclerosis
    Participants with multiple sclerosis, age 50-70 (inclusive) will undergo quantitative MRI assessments, wearable activity monitoring, and questionnaire-based assessments over the study period.

Primary Outcome Measure

Quantitative MRI-derived myelin measure [ Time Frame: Baseline and 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Multiple Sclerosis Center at UW Medical Center - NorthwestSeattleWashington98133
Susan R Robles, BS
[email protected]
206-598-0501
Sarah B Simmons, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Seattle, WA

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By condition
Multiple sclerosis
By specialty
NeurologyBrain disordersAutoimmune disease
By research site
Multiple Sclerosis Center at UW Medical Center - Northwest· Seattle, WA

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