A Study to Learn How Different Amounts of the Study Medicine Called PF-08642534 Are Tolerated and Act in the Body of People Who Have Obesity

Part of paid clinical trials in Lake Forest, California.

Sponsor
Pfizer
Study ID
NCT07731139
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • PF-08642534 — DRUG
    Participants will receive PF-08642534 QD (once a day)
  • Placebo — DRUG
    Participants will receive matching placebo QD (once a day)

Study Details

This study will look at a study drug called PF-08642534 in people with obesity (have too much body weight) to see: if participants can take different amounts (doses) of the study drug in a safe way and how adults with obesity tolerate it, and how the body handles the study drug (for example, how the study drug is absorbed and removed from the body). People who want to join the study will first go through a screening period of up to 4 weeks. Doctors will check if each person meets the study conditions, including age, body weight, and general health. People with certain medical conditions will not be able to take part in the study.

Key Dates

First listed
Jul 28, 2026
Start date
Jul 28, 2026
Status verified
Jul 2026
Primary completion
Apr 21, 2027
Completion
Apr 21, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Placebo
    Participants will receive matching placebo QD
  • Experimental: PF-08642534
    Participants will receive PF-08642534 QD

Primary Outcome Measure

Incidence of treatment emergent adverse events (TEAE) [ Time Frame: Baseline up to 8 weeks after last dose ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Orange County Research CenterLake ForestCalifornia92630-

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