A Study to Learn How Different Amounts of the Study Medicine Called PF-08642534 Are Tolerated and Act in the Body of People Who Have Obesity
Part of paid clinical trials in Lake Forest, California.
- Sponsor
- Pfizer
- Study ID
- NCT07731139
- Phase
- PHASE1
- Status
- Not Yet Recruiting
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Conditions
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 70 Years
- Healthy Volunteers
- Not accepted
Interventions
- PF-08642534 — DRUGParticipants will receive PF-08642534 QD (once a day)
- Placebo — DRUGParticipants will receive matching placebo QD (once a day)
Study Details
This study will look at a study drug called PF-08642534 in people with obesity (have too much body weight) to see: if participants can take different amounts (doses) of the study drug in a safe way and how adults with obesity tolerate it, and how the body handles the study drug (for example, how the study drug is absorbed and removed from the body). People who want to join the study will first go through a screening period of up to 4 weeks. Doctors will check if each person meets the study conditions, including age, body weight, and general health. People with certain medical conditions will not be able to take part in the study.
Key Dates
- First listed
- Jul 28, 2026
- Start date
- Jul 28, 2026
- Status verified
- Jul 2026
- Primary completion
- Apr 21, 2027
- Completion
- Apr 21, 2027
Study Design
- Enrollment
- 120 participants (estimated)
- Allocation
- RANDOMIZED
- Intervention model
- SEQUENTIAL
- Primary purpose
- BASIC_SCIENCE
Arms
- Experimental: PlaceboParticipants will receive matching placebo QD
- Experimental: PF-08642534Participants will receive PF-08642534 QD
Primary Outcome Measure
Incidence of treatment emergent adverse events (TEAE) [ Time Frame: Baseline up to 8 weeks after last dose ]
Central Contacts
- Pfizer CT.gov Call Center1-800-718-1021
Locations (1)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Orange County Research Center | Lake Forest | California | 92630 | - |
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