Study of Oral MRT-2359 With Apalutamide in Prostate Cancer

Part of paid clinical trials in Los Angeles, California.

Sponsor
Monte Rosa Therapeutics, Inc
Study ID
NCT07745361
Phase
PHASE2
Status
Recruiting
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Conditions

  • Castration-Resistant Prostate Cancer
  • Castration-Resistant Prostate Cancer (CRPC)
  • Prostate Cancer
  • Prostate Cancer (Adenocarcinoma)

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Oral MRT-2359 — DRUG
    Orally administered tablets of MRT-2359
  • Apalutamide — DRUG
    Orally administered apalutamide

Study Details

This Phase 2, open-label, multicenter study is conducted in patients with castration-resistant prostate cancer. Patients in this study receive MRT-2359, an investigational oral medicine, in combination with apalutamide, an oral medicine used to treat prostate cancer. The main purpose of the study is to assess whether this treatment combination can lower prostate-specific antigen (PSA) The study will also evaluate the safety and tolerability of the treatment combination and assess additional measures of anti-tumor activity.

Key Dates

First listed
Aug 4, 2026
Start date
Aug 31, 2026
Status verified
Aug 2026
Primary completion
Oct 31, 2027
Completion
Apr 30, 2028

Study Design

Enrollment
25 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: MRT-2359 + Apalutamide
    Participants with castration-resistant prostate cancer will receive MRT-2359 in combination with apalutamide.

Primary Outcome Measure

Assess the efficacy of MRT-2359 combined with apalutamide [ Time Frame: 14 months ]

Central Contacts

Locations (14)

FacilityCityStateZIPSite coordinators
START Los AngelesLos AngelesCalifornia90025-
Hoag Memorial Hospital PresbyterianNewport BeachCalifornia92663-
Rocky Mountain Cancer CenterColorado SpringsColorado80907-
Kansas University Cancer CenterKansas CityKansas66160-
University of Maryland Greenebaum Cancer CenterBaltimoreMaryland21201-
Henry FordNoviMichigan48377-
XCancer OmahaOmahaNebraska68130-
START New JerseyEast BrunswickNew Jersey08816-
Levine Cancer InstituteCharlotteNorth Carolina28204-
Lancaster UrologyLancasterPennsylvania17601-
Sarah Cannon Research InstituteNashvilleTennessee37203-
START Mountain RegionWest Valley CityUtah84119-
Virginia Cancer SpecialistsFairfaxVirginia22031-
University of Washington Medical CenterSeattleWashington98195-

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Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
START Los Angeles· Los Angeles, CAHoag Memorial Hospital Presbyterian· Newport Beach, CARocky Mountain Cancer Center· Colorado Springs, COKansas University Cancer Center· Kansas City, KSUniversity of Maryland Greenebaum Cancer Center· Baltimore, MDHenry Ford· Novi, MI

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