Pain Phenotypes in Individuals With Multiple Sclerosis

Sponsor
Kutahya Health Sciences University
Study ID
NCT07766213
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Pain classification method — DIAGNOSTIC_TEST
    A current clinical algorithm will be used to determine the predominant type of pain in individuals with MS. The classification to diagnose nociceptive, neuropathic and nociplastic pain will based on a recent method developed by Nijs et al. This method consists of seven steps in total. These steps question the following, respectively: duration of pain, pain distribution, presence of nociceptive pain, presence of neuropathic pain, phenomenon of hypersensitivity, presence of hypersensitization and presence of specific comorbidity. Besides, inter-rater and intra-rater reliability of pain classification algorithm will be determined by two independent researchers.

Study Details

This observational cross-sectional study aims to determine chronic pain phenotypes in individuals with multiple sclerosis (MS) and to investigate the clinical characteristics associated with different pain phenotypes. Participants with MS and chronic pain will undergo a comprehensive clinical assessment to identify nociceptive, neuropathic, nociplastic, and mixed pain phenotypes. The assessment will include clinical history, pain characteristics and distribution, quantitative sensory testing, pain intensity, disease severity, fatigue, health-related quality of life, and pain catastrophizing. The clinical characteristics of participants with different pain phenotypes will subsequently be compared.

Key Dates

First listed
Aug 14, 2026
Start date
Aug 15, 2026
Status verified
Aug 2026
Primary completion
Jun 15, 2027
Completion
Sep 15, 2027

Study Design

Enrollment
60 participants (estimated)

Primary Outcome Measure

Quantitative sensory test: static tactile mechanical threshold [ Time Frame: 10 minutes ]

Central Contacts

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