Ultrasound and Shear Wave Elastography Assessment of Entheses in Psoriatic Arthritis

Sponsor
Marmara University
Study ID
NCT07785089
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Grayscale Ultrasonography, Power Doppler Ultrasonography, and Shear Wave Elastography — DIAGNOSTIC_TEST
    Participants will undergo standardized musculoskeletal ultrasound evaluation of bilateral enthesis sites, including grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography. The imaging protocol will be identical for both the psoriatic arthritis and healthy control groups. No therapeutic intervention will be administered as part of the study.

Study Details

Psoriatic arthritis (PsA) is a chronic inflammatory disease that frequently involves the entheses, where tendons, ligaments, and fascia insert into bone. Early detection of enthesitis is important for disease assessment and management. Conventional musculoskeletal ultrasonography, including grayscale and Power Doppler ultrasonography, can identify structural and inflammatory changes, while shear wave elastography (SWE) provides quantitative information about tissue stiffness. This observational cross-sectional study aims to evaluate bilateral enthesis sites using grayscale ultrasonography, Power Doppler ultrasonography, and SWE in patients with PsA and age- and sex-matched healthy controls. The study will investigate the relationship between imaging findings and clinical disease characteristics, disease activity, functional status, and laboratory parameters. The findings may improve understanding of enthesis involvement in PsA and clarify the potential role of multimodal ultrasound assessment, including SWE, in disease evaluation.

Key Dates

First listed
Aug 25, 2026
Start date
Jul 27, 2026
Status verified
Aug 2026
Primary completion
Jul 27, 2027
Completion
Jul 27, 2027

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Psoriatic Arthritis
    Patients aged 18 years or older with psoriatic arthritis fulfilling the CASPAR classification criteria. Participants will undergo clinical assessment, laboratory evaluation, grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography of bilateral enthesis sites.
  • Arm: Healthy Controls
    Age- and sex-matched healthy volunteers without inflammatory rheumatic disease. Participants will undergo grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography of bilateral enthesis sites using the same imaging protocol as the psoriatic arthritis group.

Primary Outcome Measure

Total Madrid Sonography Enthesitis Index (MASEI) Score [ Time Frame: Baseline ]

Central Contacts

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