NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT07788755
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 79 Years
Healthy Volunteers
Accepted

Interventions

  • Perceptual Discrimination Training — DEVICE
    Perceptual discrimination training is a computerized cognitive training program delivered through the BrainHQ platform. Training involves Gabor patch and other visual stimulus discrimination exercises that focus on improving signal-to-noise resolution and attentional control. On each training trial, participants distinguish a target stimulus among distractor stimuli. Training difficulty adapts based on participant performance. Participants complete approximately 10 hours of training over 2 to 6 weeks.
  • Cognitive Control Training — DEVICE
    Cognitive control training is a computerized cognitive training program delivered through the BrainHQ platform. Training involves maintaining accurate representations of cognitive context in working memory during response selection. Training difficulty adapts based on participant performance by changing the speed of stimulus presentation or working memory load. Participants complete approximately 10 hours of training over 2 to 6 weeks.

Study Details

This study will examine brain metabolic and excitatory/inhibitory mechanisms related to cognitive and visual functioning in adults with schizophrenia and healthy control participants. Participants will complete behavioral assessments, cognitive testing, electroencephalography, magnetic resonance imaging, and magnetic resonance spectroscopy assessments. After baseline assessments, participants will be randomly assigned to one of two computerized cognitive training programs: perceptual discrimination training or cognitive control training. Each training program will include approximately 10 hours of training over 2 to 6 weeks. The study will evaluate changes in cognitive and visual task performance, EEG measures, and brain metabolite concentrations before and after cognitive training. Some participants may also complete optional extended baseline assessments before cognitive training.

Key Dates

First listed
Aug 26, 2026
Start date
Oct 1, 2026
Status verified
Aug 2026
Primary completion
Jun 1, 2031
Completion
Jun 1, 2031

Study Design

Enrollment
168 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Perceptual Discrimination Training
    Participants randomized to this arm will complete computerized perceptual discrimination training. The training involves Gabor patch and other visual stimulus discrimination exercises designed to improve signal-to-noise resolution and attentional control. Participants will complete approximately 10 hours of training over 2 to 6 weeks.
  • Experimental: Cognitive Control Training
    Participants randomized to this arm will complete computerized cognitive control training. The training involves exercises focused on maintaining cognitive context in working memory during response selection. Participants will complete approximately 10 hours of training over 2 to 6 weeks.

Primary Outcome Measure

Change in DPX Task Performance [ Time Frame: Baseline to post-training follow-up, up to 7 months; or baseline to post-training follow-up, up to 42 months for participants completing the optional extended baseline component ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Magnetic Resonance Research, University of MinnesotaMinneapolisMinnesota55455
Caroline Demro, PhD, LP
[email protected]
612-625-3330
Caroline Demro, PhD, LP (PRINCIPAL_INVESTIGATOR)

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By condition
Schizophrenia
By specialty
PsychiatryMental healthBehavioral health
By research site
Center for Magnetic Resonance Research, University of Minnesota· Minneapolis, MN

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