Prospective Multiomic Analysis in Small-Cell Lung Cancer

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University Comprehensive Cancer Center
Study ID
NCT07795411
Status
Not Yet Recruiting

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Conditions

  • Lung Cancer
  • Small Cell Cancer Of The Lung
  • Small Cell Lung Cancer ( SCLC )
  • Small-Cell Lung Cancer (SCLC)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen collection — PROCEDURE
    Undergo blood and tissue sample collection

Study Details

This is an observational study to collects blood samples and tumor tissue from adults with relapsed small-cell lung cancer (SCLC) receicing standard of care commercial DLL3 T cell engager. The goal of the study is to understand the changes in tumor markers over time and examine whether these changes are associated with clinical outcomes. Participants will provide blood samples and, when clinically feasible, tumor tissue during routine care visits, treatment, and imaging assessments. The study does not assign cancer treatment.

Key Dates

First listed
Aug 31, 2026
Start date
Nov 25, 2026
Status verified
Aug 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: Relapsed SCLC Patients
    Blood and tissue samples will be collected at baseline, during treatment, and at disease progression, in concordance with routine clinical visits and imaging assessments.

Primary Outcome Measure

Feasibility of obtaining paired tumor samples and serial blood collection [ Time Frame: Up to 3 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Ohio State University Comprehensive Cancer CenterColumbusOhio43210
Asrar Alahamadi, MBBS
[email protected]
614-293-6786
Asrar Alahmadi, MBBS, MAS-CR (PRINCIPAL_INVESTIGATOR)

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By research site
Ohio State University Comprehensive Cancer Center· Columbus, OH

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