A Study Evaluating Safety and Tolerability of Switching From Semaglutide to Zovaglutide in Adults With Obesity (HORIZON-SWITCH-SZ)

Sponsor
Beijing QL Biopharmaceutical Co.,Ltd
Study ID
NCT07812597
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • zovaglutide Arm 1 — DRUG
    Zovaglutide will be administered via subcutaneous (SC) injection.
  • zovaglutide Arm 2 — DRUG
    Zovaglutide will be administered via subcutaneous (SC) injection.
  • semaglutide — DRUG
    Semaglutide will be administered via subcutaneous (SC) injection.

Study Details

The main purpose of this study is to evaluate the safety and tolerability of continuing treatment with zovaglutide injection following titration to 2.4 mg semaglutide injection in adult participants with obesity.

Key Dates

First listed
Sep 10, 2026
Start date
Oct 12, 2026
Status verified
Sep 2026
Primary completion
Jan 13, 2028
Completion
Mar 24, 2028

Study Design

Enrollment
210 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: zovaglutide Arm1
    Participants will receive zovaglutide dosing schedule 1 after randomization.
  • Experimental: zovaglutide Arm2
    Participants will receive zovaglutide dosing schedule 2 after randomization.
  • Active Comparator: semaglutide Arm
    Participants will receive semaglutide once weekly after randomization

Primary Outcome Measure

Proportion of participants achieving successful switch from semaglutide 2.4 mg to zovaglutide after randomization [ Time Frame: from week 20 (randomization) to week 36 ]

Central Contacts

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