Multimodal Physiologic State Intelligence Study

Conditions

• Acute Kidney Injury
• Acute Respiratory Distress Syndrome
• Aortic Diseases
• Brain Aging
• Brain Aging Related Conditions
• Brain Aneurysm
• Cardiomyopathies
• Heart Failure
• Hypertension
• Muskuloskeletal Diseases
• Myocarditis Due to Drug
• Myocarditis Viral
• Myocarditis; Acute or Subacute
• Pericardial Diseases
• Peripheral Arterial Disease
• Peripheral Arterial Disease (PAD)
• Pulmonary Edema - Acute
• Pulmonary Edema With Heart Failure
• Pulmonary Edemas
• Pulmonary Embolism (Diagnosis)
• Pulmonary Embolism Acute
• Pulmonary Embolism Acute Massive
• Pulmonary Embolism Subacute Massive
• Pulmonary Hypertension
• Sepsis
• Ultrasound
• Ultrasound Exams
• Ultrasound Guidance
• Valvular Heart Diseases
• Venous Thrombosis (Disorder)
• Venous Thrombosis Pulmonary
• Venous Thrombosis, Deep

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• OMNIPHYS Multimodal Ultrasound Imaging System — DEVICE
  Observational physiologic and imaging data acquisition.

Study Details

The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state over time. The study will examine cardiac, vascular, pulmonary, and systemic physiologic measurements and develop longitudinal models that describe baseline physiology, physiologic perturbation, compensation, deterioration, treatment response, and recovery. The study is observational and will not assign experimental treatments. The goal is to determine whether changes in multimodal physiologic patterns can be identified and characterized earlier and more reliably than conventional single-time-point assessment.

Key Dates

First listed

Sep 10, 2026

Start date

Sep 2, 2026

Status verified

Sep 2026

Primary completion

Sep 2, 2046

Completion

Sep 15, 2046

Study Design

Enrollment

25,000 participants (estimated)

Arms

• Arm: OMNIPHYS Master Physiologic Cohort
  A prospective longitudinal observational cohort of participants undergoing routine clinical evaluation and/or care. The cohort will be characterized using multimodal physiologic observations, including ultrasound-derived imaging, 2D and 3D imaging, color and spectral Doppler, cardiac and vascular measurements, pulmonary ultrasound findings, vital signs, ECG, oxygen saturation, laboratory data, medications, diagnoses, clinical encounters, and longitudinal outcomes. Participants will not be assigned to an experimental treatment. Disease-specific and physiologic subcohorts may be evaluated within the master cohort using a common longitudinal physiologic-state framework.

Primary Outcome Measure

Physiologic Transition Detection Time (PTDT) [ Time Frame: Continuous longitudinal assessment from baseline (Year 0) through Year 50; PTDT will be calculated separately for each predefined clinical reference event occurring during the 50-year follow-up period. ]

Locations (1)

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