Personalizing Veterans' Lung Cancer Screening and Diagnosis

Part of paid clinical trials in Aurora, Colorado.

Sponsor
VA Office of Research and Development
Study ID
NCT07838519
Status
Enrolling By Invitation

Conditions

  • Agent Orange Exposure
  • Asbestos Exposure
  • Burn Pit Exposure
  • COPD
  • Cancer Survivor
  • Family History of Lung Cancer
  • Lung Cancer Screening
  • Lung Neoplasm
  • Military Service-related Environmental and Occupational Exposures
  • Radiation Exposure

Eligibility Criteria

Sex
ALL
Age
50 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Low-dose computed tomography — PROCEDURE
    CT exam that uses low-dose radiation

Study Details

Lung cancer screening with low-dose chest computed tomography (CT) is currently recommended for high-risk individuals who are 50 to 80 years old, have smoked cigarettes for at least 20 pack-years, and currently smoke or quit smoking within the past 15 years. In a prospective cohort at Nashville, Denver, Louisville, Chicago, Kansas City, Salisbury and Seattle Veteran Affairs medical centers, the investigators will evaluate the detection of lung cancer using an expanded screening eligibility criteria based on Veterans' personal and service-related exposures compared to standard of care criteria. Screening a larger population will increase the number of lung nodules needing clinical management and these nodules may or may not be cancer. In a population of Veterans with positive screenings at Nashville, the investigators will also validate a combination biomarker-based approach to manage screen-detected lung nodules to reduce time to lung cancer diagnosis and use of invasive procedures. This study will also convene a Veteran Community Advisory Board and interview Veterans to better understand their thoughts about lung cancer screening and preferences for outreach and engagement.

Key Dates

First listed
Sep 24, 2026
Start date
Apr 3, 2024
Status verified
Sep 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
1,400 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING

Arms

  • Experimental: Expanded population
    All study participants enrolled receive annual screening for lung cancer with low-dose computed tomography (LDCT)

Primary Outcome Measure

Lung cancer incidence [ Time Frame: 3-44 months from time of study enrollment ]

Locations (7)

FacilityCityStateZIPSite coordinators
Rocky Mountain Regional VA Medical Center, Aurora, COAuroraColorado80045-7211-
Jesse Brown VA Medical Center, Chicago, ILChicagoIllinois60612-
Robley Rex VA Medical Center, Louisville, KYLouisvilleKentucky40206-1433-
Kansas City VA Medical Center, Kansas City, MOKansas CityMissouri64128-2226-
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NCSalisburyNorth Carolina28144-
Tennessee Valley Healthcare System Nashville Campus, Nashville, TNNashvilleTennessee37212-2637-
VA Puget Sound Health Care System Seattle Division, Seattle, WASeattleWashington98108-1532-

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By research site
Rocky Mountain Regional VA Medical Center, Aurora, CO· Aurora, COJesse Brown VA Medical Center, Chicago, IL· Chicago, ILRobley Rex VA Medical Center, Louisville, KY· Louisville, KYKansas City VA Medical Center, Kansas City, MO· Kansas City, MOSalisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC· Salisbury, NCTennessee Valley Healthcare System Nashville Campus, Nashville, TN· Nashville, TN

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