Clinical Trials at Medical University of South Carolina

As of August 2026, 345 paid clinical trials are recruiting at Medical University of South Carolina, located at 96 JONATHAN LUCAS ST, SUITE 309, CHARLESTON, SC 29425-8900, phone (843) 792-3221 in Charleston, South Carolina. Active studies at this site cover conditions such as Stroke, Depression and Heart Failure. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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Healthy volunteers only

Newly added in Charleston

Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.

An Observational Study of Patients With Dermatologic Disease

for Vitiligo

Sites in Charleston +2 more locations

Sponsor: Target PharmaSolutions, Inc.

Sex: All·Age: All ages

Code: NCT07748169·Recruiting·Listed Aug 5, 2026

Apply to this trial

Superior Parietal iTBS for PD-MCI

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 50 - 85

Code: NCT07701785·Recruiting·Listed Jul 14, 2026

Apply to this trial

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label

for Olfactory Impairment

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 80

Code: NCT07689773·Phase 2·Recruiting·Listed Jul 8, 2026

Apply to this trial

Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation

for Aphasia

Sites in Charleston, Columbia +1 more location

Sponsor: University of South Carolina

Sex: All·Age: 25 - 80

Code: NCT07688551·Phase 2, Phase 3·Recruiting·Listed Jul 7, 2026

Apply to this trial

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

for EDS

Sites in Charleston, Columbia +48 more locations

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 18+

Code: NCT07675135·Phase 3·Recruiting·Listed Jun 30, 2026

Apply to this trial

350 clinical trials at Medical University of South Carolina

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LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis (UC)

Drug: LY4268989

Sites in Charleston +49 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07415044·Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

for Hepatitis

Drug: Larsucosterol

Sites in Charleston +83 more locations

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 18+

Code: NCT07428538·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

for Liver Cirrhosis

Drug: BI 3802876

Sites in Charleston +25 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 75

Code: NCT07325526·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study

for Ventricular Arrythmia

Sites in Charleston +26 more locations

Sponsor: AtaCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT07324031·Recruiting·Listed Jan 2026

Apply to this trial

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

for Breast Neoplasms

Sites in Charleston +121 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07174336·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

for Elevated Lp(a)

Drug: Muvalaplin

Sites in Charleston, Little River +138 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07157774·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

for Ovarian Neoplasms

Sites in Charleston +87 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213804·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

for Cardiovascular Disease

Drug: Olpasiran

Sites in Charleston, Mt. Pleasant +197 more locations

Sponsor: Amgen

Sex: All·Age: 50 - 105

Code: NCT07136012·Phase 3·Recruiting·Listed Aug 2025

Apply to this trial

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

for Pulmonary Arterial Hypertension

Sites in Charleston +11 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07218029·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

for Metabolic Dysfunction Associated Steatohepatitis (MASH)

Drug: Survodutide

Sites in Charleston, Summerville +161 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06632444·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Drug: Amivantamab

Sites in Charleston +127 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06667076·Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

for Triple Negative Breast Cancer

Sites in Charleston, Spartanburg +122 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05633654·Phase 3·Recruiting·Listed Dec 2022

Apply to this trial

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

Sites in Charleston, West Columbia +88 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

for Lymphoma, Large B-Cell, Diffuse

Drug: Polatuzumab Vedotin

Sites in Charleston +70 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06890884·Phase 2·Recruiting·Listed Mar 2025

Apply to this trial

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

Sites in Charleston, West Columbia +86 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting·Listed Nov 2023

Apply to this trial

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

for COVID-19 SARS-CoV-2 Infection

Sites in Charleston +83 more locations

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06679140·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

for COVID-19 Infection

Sites in Charleston +65 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07013474·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Drug: Telisotuzumab Vedotin

Sites in Charleston, Greenville +36 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06568939·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

for Diabetes Mellitus, Type 2

Sites in Charleston +122 more locations

Sponsor: Cleerly, Inc.

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06112418·Recruiting·Listed Nov 2023

Apply to this trial

Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Etentamig

Sites in Charleston +34 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06158841·Phase 3·Recruiting·Listed Dec 2023

Apply to this trial

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

for Primary Biliary Cholangitis

Sites in Charleston +51 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06051617·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

Sites in Charleston +37 more locations

Sponsor: Incyte Corporation

Sex: Female·Age: 18 - 99

Code: NCT07023627·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab

for Atopic Dermatitis

Drug: Upadacitinib

Sites in Charleston, Spartanburg +64 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 63

Code: NCT06389136·Phase 3·Recruiting·Listed Apr 2024

Apply to this trial

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

for Depressive Disorder, Major

Drug: Seltorexant

Sites in Charleston +41 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT06559306·Phase 3·Recruiting·Listed Aug 2024

Apply to this trial

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

for Parkinson Disease

Sites in Charleston +44 more locations

Sponsor: Neuron23 Inc.

Sex: All·Age: 40 - 80

Code: NCT06680830·Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohns Disease

Drug: Afimkibart

Sites in Charleston, Greenville +90 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06819878·Phase 3·Recruiting·Listed Feb 2025

Apply to this trial

A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

Drug: Avacopan

Sites in Charleston, Spartanburg +56 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting·Listed Oct 2023

Apply to this trial

ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

for Autosomal Dominant Polycystic Kidney Disease

Sites in Charleston +36 more locations

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18 - 55

Code: NCT06902558·Phase 2·Recruiting·Listed Mar 2025

Apply to this trial

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

for Hypertension

Sites in Charleston +69 more locations

Sponsor: Orchestra BioMed, Inc

Sex: All·Age: 18+

Code: NCT06059638·Recruiting·Listed Sep 2023

Apply to this trial

A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata

for Areata Alopecia

Drug: Baricitinib

Sites in Charleston +40 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 6 - 17

Code: NCT05723198·Phase 3·Recruiting·Listed Feb 2023

Apply to this trial

Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy

for Cancer Weight Loss

Sites in Charleston +24 more locations

Sponsor: Endevica Bio

Sex: All·Age: 18+

Code: NCT06937177·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis

for Primary Biliary Cholangitis (PBC)

Drug: Elafibranor

Sites in Charleston +30 more locations

Sponsor: Ipsen

Sex: All·Age: 18+

Code: NCT06016842·Phase 3·Recruiting·Listed Aug 2023

Apply to this trial

An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)

for Progressive Pulmonary Fibrosis

Sites in Charleston +25 more locations

Sponsor: Avalyn Pharma Inc.

Sex: All·Age: 18+

Code: NCT06951217·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

for Chronic Graft-versus-host-disease

Sites in Charleston, Greenville +34 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06585774·Phase 3·Recruiting·Listed Sep 2024

Apply to this trial

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

for Myelofibrosis

Sites in Charleston +29 more locations

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT04176198·Phase 1, Phase 2·Recruiting·Listed Nov 2019

Apply to this trial

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

for Clostridium Difficile

Sites in Charleston +55 more locations

Sponsor: Vedanta Biosciences, Inc.

Sex: All·Age: 12+

Code: NCT06237452·Phase 3·Recruiting·Listed Feb 2024

Apply to this trial

Global Paradise System US Post Approval Study

for Hypertension

Sites in Charleston, Columbia +41 more locations

Sponsor: ReCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT06297291·Recruiting·Listed Mar 2024

Apply to this trial

Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer

for Low-grade NMIBC

Sites in Charleston, North Charleston +33 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06995677·Phase 2·Recruiting·Listed May 2025

Apply to this trial

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis

Drug: Upadacitinib

Sites in Charleston +25 more locations

Sponsor: AbbVie

Sex: All·Age: 2 - 11

Code: NCT06461897·Phase 3·Recruiting·Listed Jun 2024

Apply to this trial

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

Sites in Charleston +52 more locations

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting·Listed Mar 2019

Apply to this trial

Common conditions studied in Charleston

Stroke (15 active studies)
Depression (13 active studies)
Heart Failure (13 active studies)
Acute Myeloid Leukemia (8 active studies)
Cardiovascular Diseases (8 active studies)
Obesity (8 active studies)

Leading research sponsors in Charleston

Medical University of South Carolina
National Cancer Institute (NCI)
VA Office of Research and Development
AstraZeneca
NRG Oncology

Frequently asked questions

How many paid clinical trials are currently recruiting in Charleston?

There are approximately 686 recruiting clinical trials in Charleston, South Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in Charleston pay participants?

Most recruiting trials in Charleston compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in Charleston?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in Charleston?

The most common conditions under active study in Charleston include Stroke (15), Depression (13), Heart Failure (13), Acute Myeloid Leukemia (8), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in Charleston?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Charleston on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in Charleston?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Where can I take part in paid clinical trials in Charleston?

Recruiting research sites in Charleston include Medical University of South Carolina, Medical University of South Carolina (MUSC), Ralph H. Johnson VA Medical Center, Charleston, SC, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.

What kinds of studies are recruiting in Charleston right now?

The largest active categories in Charleston are Cancer & tumors (166), Neurology & pain (61), Mental health & behavior (60). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.

What is the address of Medical University of South Carolina?

Medical University of South Carolina is located at 96 JONATHAN LUCAS ST, SUITE 309, CHARLESTON, SC 29425-8900. Use the Google Maps link in the intro above to get directions.

How do I contact Medical University of South Carolina?

You can reach Medical University of South Carolina by phone at (843) 792-3221. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.

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Other cities in South Carolina

Related healthcare resources in South Carolina

Latest Charleston, SC clinical trials research report

Trials by condition in Charleston

Stroke· 15 Depression· 13 Heart Failure· 13 Acute Myeloid Leukemia· 8 Obesity· 8 Prostate Cancer· 8 Atopic Dermatitis· 7