Clinical Trials at University of Chicago Medical Center

As of August 2026, 95 paid clinical trials are recruiting at University of Chicago Medical Center, located at 5841 S MARYLAND AVE, CHICAGO, IL 60637, phone (773) 702-0292 in Chicago, Illinois. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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96 clinical trials at University of Chicago Medical Center

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Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

for Multiple Sclerosis, Relapsing-Remitting

Sites in Chicago +8 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 10 - 17

Code: NCT06408259·Phase 3·Recruiting·Listed May 2024

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Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

for Relapsed/Refractory Multiple Myeloma

Sites in Chicago +6 more locations

Sponsor: Ichnos Sciences SA

Sex: All·Age: 18+

Code: NCT05862012·Phase 1·Recruiting·Listed May 2023

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An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

for Emphysema, Pulmonary

Sites in Chicago, Peoria +14 more locations

Sponsor: Pulmonx Corporation

Sex: All·Age: 40 - 80

Code: NCT06035120·Recruiting·Listed Sep 2023

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A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

for Advanced or Metastatic Solid Tumors

Sites in Chicago +13 more locations

Sponsor: 858 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06395519·Phase 1, Phase 2·Recruiting·Listed May 2024

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Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

for Heart Failure With Preserved Ejection Fraction (HFpEF

Sites in Chicago +12 more locations

Sponsor: Axon Therapies, Inc.

Sex: All·Age: 40+

Code: NCT04592445·Recruiting·Listed Oct 2020

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Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

for Motor Function

Sites in Chicago, Peoria +6 more locations

Sponsor: Guerbet

Sex: All·Age: 18 - 64

Code: NCT04373564·Phase 4·Recruiting·Listed May 2020

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First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

Sites in Chicago +22 more locations

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting·Listed Jan 2022

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FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Chicago +13 more locations

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT06241456·Phase 1·Recruiting·Listed Feb 2024

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Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for Cancer

Sites in Chicago +14 more locations

Sponsor: MBrace Therapeutics

Sex: All·Age: 18+

Code: NCT06014658·Phase 1, Phase 2·Recruiting·Listed Aug 2023

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Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )

for Pancreatic Cancer

Sites in Chicago +5 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT07621718·Phase 3·Recruiting·Listed Jun 2026

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A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement

for FGFR2 Gene Fusion/Rearrangement

Drug: Lirafugratinib

Sites in Chicago +6 more locations

Sponsor: Elevar Therapeutics

Sex: All·Age: 18+

Code: NCT07359820·Phase 2·Recruiting·Listed Jan 2026

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A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

for Ulcerative Colitis

Sites in Chicago +7 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06979336·Phase 2·Recruiting·Listed May 2025

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Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

Sites in Chicago +8 more locations

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting·Listed Dec 2020

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Pharmacokinetic and Early Efficacy of OPT101 in Patients With Type 1 Diabetes Mellitus

for Type I Diabetes

Sites in Chicago +4 more locations

Sponsor: Op-T LLC

Sex: All·Age: 18 - 50

Code: NCT06964087·Phase 2·Recruiting·Listed May 2025

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Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty

for Total Knee Arthroplasty (TKA)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07672301·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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Impact of Barostimulation on Hemodynamics in Adults With Heart Failure

for HFrEF - Heart Failure With Reduced Ejection Fraction

Sites in Chicago +6 more locations

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT07335510·Recruiting·Listed Jan 2026

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Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

for Intracerebral Hemorrhage

Sites in Chicago, Winfield +47 more locations

Sponsor: Joseph Broderick, MD

Sex: All·Age: 18 - 80

Code: NCT07227246·Phase 3·Recruiting·Listed Nov 2025

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QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

for HER2-positive Metastatic Breast Cancer

Sites in Chicago, Orland Park +35 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06551116·Recruiting·Listed Aug 2024

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TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for Breast Cancer

Sites in Chicago +9 more locations

Sponsor: Ana C Garrido-Castro, MD

Sex: All·Age: 18+

Code: NCT06533826·Phase 2·Recruiting·Listed Aug 2024

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DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

for Ductal Carcinoma in Situ

Sites in Chicago +24 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: Female·Age: 18+

Code: NCT06075953·Phase 2·Recruiting·Listed Oct 2023

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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

for Stroke

Sites in Chicago, Carbondale +26 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05907629·Recruiting·Listed Jun 2023

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The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

Sites in Chicago +32 more locations

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting·Listed Sep 2023

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

Sites in Chicago, Maywood +140 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

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Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

for Pulmonary Embolism

Sites in Chicago, Maywood +38 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05591118·Phase 3·Recruiting·Listed Oct 2022

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Kidney Stone Inflammation

for Kidney Stone

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06436235·Recruiting·Listed May 2024

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Gluten Technology and Education for Celiac Health

for Celiac Disease

Sites in Chicago +3 more locations

Sponsor: Columbia University

Sex: All·Age: 18 - 75

Code: NCT06059716·Recruiting·Listed Sep 2023

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Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

Drug: Ruxolitinib

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 39

Code: NCT03571321·Phase 1·Recruiting·Listed Jun 2018

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Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO)

for Lymphoblastic Leukemia

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04747912·Phase 2·Recruiting·Listed Feb 2021

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Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

Sites in Chicago +51 more locations

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting·Listed Apr 2025

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Chicago +14 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

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Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery

for Bariatric Surgery Candidate

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 130

Code: NCT04590690·Recruiting·Listed Oct 2020

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Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

for Cirrhosis, Liver

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 75

Code: NCT06950788·Recruiting·Listed Apr 2025

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At-home Walking Cadence Functional Assessment and Recovery Trajectory for Older Adults Undergoing Major Surgery

for Gait, Unsteady

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 60+

Code: NCT05886725·Recruiting·Listed Jun 2023

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Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

Sites in Chicago +18 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting·Listed Mar 2021

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Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

for Schizophrenia Spectrum and Other Psychotic Disorders

Sites in Chicago +5 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40

Code: NCT06740383·Recruiting·Listed Dec 2024

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Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

Sites in Chicago +67 more locations

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting·Listed Apr 2015

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The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing

for Patients Undergoing Routine Health Care

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01280825·Recruiting·Listed Jan 2011

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A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

for Metastatic Breast Cancer

Sites in Chicago +11 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06099769·Phase 2·Recruiting·Listed Oct 2023

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Avo In R/R And Previously Untreated MCL

for Mantle Cell Lymphoma

Sites in Chicago +2 more locations

Sponsor: Austin I Kim

Sex: All·Age: 18+

Code: NCT04855695·Phase 1, Phase 2·Recruiting·Listed Apr 2021

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Chicago +40 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

Apply to this trial