Recovery Legal Care Randomized Trial
for Firearm Injury
1 location in Chicago
Sponsor: University of Chicago
Sex: All·Age: 14+
Code: NCT07764458·Recruiting·Listed Aug 14, 2026
Clinical Trials at University of Chicago Medical Center
As of August 2026, 95 paid clinical trials are recruiting at University of Chicago Medical Center, located at 5841 S MARYLAND AVE, CHICAGO, IL 60637, phone (773) 702-0292 in Chicago, Illinois. Active studies at this site cover conditions such as Breast Cancer, Obesity and Stroke. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Chicago
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
96 clinical trials at University of Chicago Medical Center
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A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
for Metabolic Dysfunction-Associated Steatotic Liver Disease
Sites in Chicago +141 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07165028·Phase 3·Recruiting·Listed Sep 2025
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
for Carcinoma, Transitional Cell
Sites in Chicago, Evanston +62 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07218380·Phase 3·Recruiting·Listed Oct 2025
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
for Urothelial Carcinoma
Sites in Chicago, Harvey +141 more locations
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Sex: All·Age: 18+
Code: NCT04879329·Phase 2·Recruiting·Listed May 2021
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
for Carcinoma, Non-Small-Cell Lung
Drug: LY3537982
Sites in Chicago, North Chicago +89 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT06890598·Phase 3·Recruiting·Listed Mar 2025
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
for Triple Negative Breast Cancer
Sites in Chicago, Evanston +122 more locations
Sponsor: Gilead Sciences
Sex: All·Age: 18+
Code: NCT05633654·Phase 3·Recruiting·Listed Dec 2022
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
for Chronic Lymphocytic Leukemia
Sites in Chicago +45 more locations
Sponsor: BeOne Medicines
Sex: All·Age: 18+
Code: NCT06973187·Phase 3·Recruiting·Listed May 2025
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Chicago, Oak Park +2367 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
for Neoplasms
Sites in Chicago +77 more locations
Sponsor: Celgene
Sex: All·Age: All ages
Code: NCT03435796·Phase 2, Phase 3·Recruiting·Listed Feb 2018
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
for Primary Biliary Cholangitis
Sites in Chicago +51 more locations
Sponsor: Gilead Sciences
Sex: All·Age: 18+
Code: NCT06051617·Phase 3·Recruiting·Listed Sep 2023
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
for Carcinoma, Non-Small Cell Lung
Drug: sigvotatug vedotin
Sites in Chicago, Harvey +102 more locations
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Sex: All·Age: 18+
Code: NCT04389632·Phase 1·Recruiting·Listed May 2020
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
for Mantle Cell Lymphoma
Drug: Sonrotoclax
Sites in Chicago +40 more locations
Sponsor: BeOne Medicines
Sex: All·Age: 18+
Code: NCT06742996·Phase 3·Recruiting·Listed Dec 2024
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
for Depressive Disorder, Major
Drug: Seltorexant
Sites in Chicago, Naperville +40 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18 - 74
Code: NCT06559306·Phase 3·Recruiting·Listed Aug 2024
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
for Melanoma, Cutaneous Malignant
Sites in Chicago +42 more locations
Sponsor: Immatics US, Inc.
Sex: All·Age: 18+
Code: NCT06743126·Phase 3·Recruiting·Listed Dec 2024
A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer
for Advanced Breast Cancer
Sites in Chicago +36 more locations
Sponsor: Stemline Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06638307·Phase 1·Recruiting·Listed Oct 2024
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
for Adjustment Disorder
Sites in Chicago +31 more locations
Sponsor: Reunion Neuroscience Inc
Sex: All·Age: 18 - 80
Code: NCT07002034·Phase 2·Recruiting·Listed Jun 2025
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
for Prostate Cancer
Drug: JANX007
Sites in Chicago +32 more locations
Sponsor: Janux Therapeutics
Sex: Male·Age: 18 - 100
Code: NCT05519449·Phase 1·Recruiting·Listed Aug 2022
ELEVATE High-Risk PCI Pivotal Study
for High-Risk Percutaneous Coronary Intervention (High-risk PCI)
Sites in Chicago +32 more locations
Sponsor: Magenta Medical Ltd.
Sex: All·Age: 18 - 88
Code: NCT07001332·Recruiting·Listed Jun 2025
Strategy for Improving Stroke Treatment Response
for Ischemic Stroke
Sites in Chicago +39 more locations
Sponsor: Translational Sciences, Inc.
Sex: All·Age: 18+
Code: NCT05948566·Phase 2·Recruiting·Listed Jul 2023
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
for Cutaneous Squamous Cell Carcinoma (CSCC)
Drug: Cemiplimab
Sites in Chicago, Naperville +42 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: All·Age: 18+
Code: NCT06585410·Phase 3·Recruiting·Listed Sep 2024
Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma
for Multiple Myeloma
Sites in Chicago +37 more locations
Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Sex: All·Age: 18+
Code: NCT06297226·Phase 2·Recruiting·Listed Mar 2024
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
for Type 1 Diabetes Mellitus With Hypoglycemia
Sites in Chicago +36 more locations
Sponsor: Zucara Therapeutics Inc.
Sex: All·Age: 18 - 75
Code: NCT05762107·Phase 2·Recruiting·Listed Mar 2023
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
for Metastatic Urothelial Cancer
Sites in Chicago, Springfield +25 more locations
Sponsor: Gilead Sciences
Sex: All·Age: 18+
Code: NCT03547973·Phase 2·Recruiting·Listed Jun 2018
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
for Metastatic Uveal Melanoma
Drug: Nivolumab
Sites in Chicago +28 more locations
Sponsor: Replimune, Inc.
Sex: All·Age: All ages
Code: NCT06581406·Phase 2, Phase 3·Recruiting·Listed Sep 2024
CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.
for Epithelial Ovarian Cancer
Sites in Chicago +25 more locations
Sponsor: TORL Biotherapeutics, LLC
Sex: Female·Age: 18+
Code: NCT06690775·Phase 2·Recruiting·Listed Nov 2024
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
for COVID-19
Sites in Chicago +23 more locations
Sponsor: Pfizer
Sex: All·Age: 0 - 17
Code: NCT05261139·Phase 3·Recruiting·Listed Mar 2022
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)
for GIST - Gastrointestinal Stromal Tumor
Sites in Chicago +16 more locations
Sponsor: Kumquat Biosciences Inc.
Sex: All·Age: 18+
Code: NCT07406633·Phase 2·Recruiting·Listed Feb 2026
A Study of PHST001 in Advanced Solid Tumors
for Advanced Solid Tumors
Sites in Chicago +19 more locations
Sponsor: Pheast Therapeutics
Sex: All·Age: 18+
Code: NCT06840886·Phase 1·Recruiting·Listed Feb 2025
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
for Ovarian Cancer
Sites in Chicago +16 more locations
Sponsor: Xencor, Inc.
Sex: All·Age: 15+
Code: NCT06276491·Phase 1·Recruiting·Listed Feb 2024
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
for Advanced Solid Tumor
Drug: Tulmimetostat
Sites in Chicago +6 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 18+
Code: NCT04104776·Phase 1, Phase 2·Recruiting·Listed Sep 2019
Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma
for Multiple Myeloma Refractory
Sites in Chicago +19 more locations
Sponsor: CellCentric Ltd.
Sex: All·Age: 18+
Code: NCT07096778·Phase 2·Recruiting·Listed Jul 2025
Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)
for Central Line Associated Blood Stream Infections (CLABSI)
Sites in Chicago +15 more locations
Sponsor: CorMedix Therapeutics
Sex: All·Age: 18+
Code: NCT06822426·Phase 3·Recruiting·Listed Feb 2025
A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms
for Myeloproliferative Neoplasms
Sites in Chicago +11 more locations
Sponsor: Incyte Corporation
Sex: All·Age: 18+
Code: NCT07008118·Phase 1·Recruiting·Listed Jun 2025
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
for Relapsed/Refractory Multiple Myeloma
Drug: Daratumumab
Sites in Chicago +14 more locations
Sponsor: BeOne Medicines
Sex: All·Age: 18+
Code: NCT04973605·Phase 1, Phase 2·Recruiting·Listed Jul 2021
A Study of 177Lu-FAP-2286 in Advanced Solid Tumors
for Solid Tumor
Sites in Chicago +19 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 18+
Code: NCT04939610·Phase 1, Phase 2·Recruiting·Listed Jun 2021
Study of XB010 in Subjects With Solid Tumors
for Locally Advanced or Metastatic Solid Tumors
Sites in Chicago +15 more locations
Sponsor: Exelixis
Sex: All·Age: 18+
Code: NCT06545331·Phase 1·Recruiting·Listed Aug 2024
A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab
for Ovarian Cancer
Drug: Cemiplimab
Sites in Chicago +11 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: Female·Age: 18+
Code: NCT04590326·Phase 1, Phase 2·Recruiting·Listed Oct 2020
A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
for Ulcerative Colitis
Sites in Chicago +19 more locations
Sponsor: Pfizer
Sex: All·Age: 12 - 17
Code: NCT05287126·Phase 2·Recruiting·Listed Mar 2022
Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma
for Cholangiocarcinoma
Drug: Trametinib
Sites in Chicago +7 more locations
Sponsor: Genfit
Sex: All·Age: 18+
Code: NCT05874414·Phase 1, Phase 2·Recruiting·Listed May 2023
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
for Locally Advanced Solid Tumor
Sites in Chicago +19 more locations
Sponsor: Nuvalent Inc.
Sex: All·Age: 12+
Code: NCT05384626·Phase 1, Phase 2·Recruiting·Listed May 2022
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
for Refractory Cancer
Drug: Nivolumab
Sites in Chicago +12 more locations
Sponsor: Immatics US, Inc.
Sex: All·Age: 18+
Code: NCT03686124·Phase 1, Phase 2·Recruiting·Listed Sep 2018
Common conditions studied in Chicago
- Breast Cancer (35 active studies)
- Obesity (27 active studies)
- Stroke (25 active studies)
- Heart Failure (24 active studies)
- Acute Myeloid Leukemia (23 active studies)
- Hypertension (22 active studies)
Leading research sponsors in Chicago
- Northwestern University
- University of Chicago
- University of Illinois at Chicago
- National Cancer Institute (NCI)
- Rush University Medical Center
Frequently asked questions
How many paid clinical trials are currently recruiting in Chicago?
There are approximately 2,151 recruiting clinical trials in Chicago, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Chicago pay participants?
Most recruiting trials in Chicago compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Chicago?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Chicago?
The most common conditions under active study in Chicago include Breast Cancer (35), Obesity (27), Stroke (25), Heart Failure (24), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Chicago?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chicago on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Chicago?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Chicago?
Recruiting research sites in Chicago include Northwestern University, University of Chicago, Rush University Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Chicago right now?
The largest active categories in Chicago are Cancer & tumors (601), Neurology & pain (149), Cardiovascular (116). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of University of Chicago Medical Center?
University of Chicago Medical Center is located at 5841 S MARYLAND AVE, CHICAGO, IL 60637. Use the Google Maps link in the intro above to get directions.
How do I contact University of Chicago Medical Center?
You can reach University of Chicago Medical Center by phone at (773) 702-0292. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.
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