Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

for Endometrial Cancer

Sites in Peoria +11 more locations

Sponsor: Whitehawk Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07444814·Phase 1·Recruiting·Listed Mar 2026

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A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

for Diabetes Mellitus, Type 2

Drug: NNC0662-0419

Sites in Chicago +22 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18 - 75

Code: NCT07415954·Phase 2·Recruiting·Listed Feb 2026

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A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults

for Stargardt Disease

Sites in Chicago +14 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 6+

Code: NCT07425574·Recruiting·Listed Feb 2026

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Immune Modulation During Palynziq® Treatment in Adults (IMPALA)

for Phenylketonuria

Sites in Chicago +11 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 18 - 65

Code: NCT07477691·Phase 4·Recruiting·Listed Mar 2026

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Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)

for Non-Arteritic Anterior Ischemic Optic Neuropathy

Sites in Chicago +21 more locations

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 50 - 80

Code: NCT07453888·Phase 3·Recruiting·Listed Mar 2026

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A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

Sites in Skokie +24 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3·Recruiting·Listed Feb 2026

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

Sites in Chicago +48 more locations

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting·Listed Feb 2026

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Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer

for Advanced Urothelial Cancer

Sites in Zion +9 more locations

Sponsor: Generate Biomedicines

Sex: All·Age: 18+

Code: NCT07484022·Phase 1·Recruiting·Listed Mar 2026

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A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

for CKD

Sites in Chicago +23 more locations

Sponsor: Renibus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07355062·Phase 3·Recruiting·Listed Jan 2026

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KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

for GIST - Gastrointestinal Stromal Tumor

Sites in Chicago +16 more locations

Sponsor: Kumquat Biosciences Inc.

Sex: All·Age: 18+

Code: NCT07406633·Phase 2·Recruiting·Listed Feb 2026

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Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia

for Schizophrenia

Sites in Chicago +12 more locations

Sponsor: LB Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07363577·Phase 3·Recruiting·Listed Jan 2026

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Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

Sites in Chicago +15 more locations

Sponsor: Madrigal Pharmaceuticals, Inc.

Sex: All·Age: 18 - 75

Code: NCT07335601·Phase 2·Recruiting·Listed Jan 2026

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A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

for Arthritis, Psoriatic

Sites in Willowbrook +15 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07321873·Phase 2·Recruiting·Listed Jan 2026

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Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

for Multiple Sclerosis

Drug: Frexalimab

Sites in Northbrook +21 more locations

Sponsor: Sanofi

Sex: All·Age: 18 - 60

Code: NCT07325292·Phase 3·Recruiting·Listed Jan 2026

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A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

for Huntington Disease

Sites in Chicago +33 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 21 - 70

Code: NCT07326709·Phase 3·Recruiting·Listed Jan 2026

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A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer

for Advanced Breast Cancer

Sites in Evanston, Springfield +21 more locations

Sponsor: TerSera Therapeutics LLC

Sex: Female·Age: 18 - 55

Code: NCT07310420·Phase 1·Recruiting·Listed Dec 2025

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A Study to Assess Real-World Use and Outcomes of TAR-200 for Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) in the United States

for Non-Muscle Invasive Bladder Neoplasms

Sites in Chicago Ridge +16 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07309445·Recruiting·Listed Dec 2025

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Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)

for Coronary Artery Disease

Sites in Chicago +18 more locations

Sponsor: Supira Medical

Sex: All·Age: 18 - 90

Code: NCT07296744·Recruiting·Listed Dec 2025

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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

Sites in Skokie +21 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting·Listed Jan 2026

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A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

for Ovarian Neoplasms

Sites in Arlington Heights +25 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT07318558·Phase 3·Recruiting·Listed Jan 2026

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Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

for Amyotrophic Lateral Sclerosis

Sites in Chicago +17 more locations

Sponsor: Prilenia

Sex: All·Age: 18 - 80

Code: NCT07322003·Phase 3·Recruiting·Listed Jan 2026

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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

for Schizophrenia

Drug: KarXT

Sites in Chicago +19 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 13 - 17

Code: NCT07288567·Phase 3·Recruiting·Listed Dec 2025

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Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma

for Low Grade Upper Tract Urothelial Carcinoma

Sites in Lisle +18 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT07265947·Phase 2·Recruiting·Listed Dec 2025

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A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

for Hepatocellular Carcinoma (HCC)

Drug: Ipilimumab

Sites in Chicago +10 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07291076·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects

for Multiple Myeloma (MM)

Drug: Elranatamab

Sites in Maywood +19 more locations

Sponsor: C4 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07280013·Phase 1·Recruiting·Listed Dec 2025

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A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy

for Spinal Muscular Atrophy (SMA)

Sites in Chicago +14 more locations

Sponsor: argenx

Sex: All·Age: 5 - 17

Code: NCT07287982·Phase 2·Recruiting·Listed Dec 2025

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A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasis

for Plaque Psoriasis

Drug: Zasocitinib

Sites in Rolling Meadows +10 more locations

Sponsor: Takeda

Sex: All·Age: 4 - 17

Code: NCT07250802·Phase 3·Recruiting·Listed Nov 2025

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A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures

for Focal Seizures

Sites in Chicago +23 more locations

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 12 - 75

Code: NCT07233239·Phase 1·Recruiting·Listed Nov 2025

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Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

for Obesity

Sites in Springfield +23 more locations

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284875·Phase 3·Recruiting·Listed Dec 2025

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A Study of NNZ-2591 in Pediatric Participants With Phelan-McDermid Syndrome

for Phelan-McDermid Syndrome

Sites in Chicago +13 more locations

Sponsor: Neuren Pharmaceuticals Limited

Sex: All·Age: 3 - 12

Code: NCT07281079·Phase 3·Recruiting·Listed Dec 2025

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Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma

for Clear Cell Renal Cell Carcinoma

Sites in Zion +11 more locations

Sponsor: Neomorph, Inc

Sex: All·Age: 18+

Code: NCT07300241·Phase 1·Recruiting·Listed Dec 2025

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A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System

for Atrial Fibrillation

Sites in Naperville +21 more locations

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 22+

Code: NCT07227532·Recruiting·Listed Nov 2025

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Transition to KPL-387 Monotherapy Dosing & Administration Study

for Recurrent Pericarditis

Sites in Chicago +15 more locations

Sponsor: Kiniksa Pharmaceuticals International, plc

Sex: All·Age: 18 - 80

Code: NCT07288216·Phase 2·Recruiting·Listed Dec 2025

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A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

for Asthma

Drug: Brenipatide

Sites in Westchester +16 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07219173·Phase 2·Recruiting·Listed Oct 2025

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A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Sites in Chicago +22 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07266831·Phase 2, Phase 3·Recruiting·Listed Dec 2025

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Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

for Non-Small-Cell Lung Cancer

Sites in Chicago, Arlington Heights +18 more locations

Sponsor: ArriVent BioPharma, Inc.

Sex: All·Age: 18+

Code: NCT07185997·Phase 3·Recruiting·Listed Sep 2025

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Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

for Primary Membranous Nephropathy

Sites in Hinsdale +25 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 75

Code: NCT07204275·Phase 2, Phase 3·Recruiting·Listed Oct 2025

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Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)

for Fragile X Syndrome

Sites in Chicago +14 more locations

Sponsor: Mirum Pharmaceuticals, Inc.

Sex: Male·Age: 13 - 45

Code: NCT07209462·Phase 2·Recruiting·Listed Oct 2025

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Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

Sites in O'Fallon +12 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07217587·Phase 3·Recruiting·Listed Oct 2025

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A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan

for Solid Tumors Harboring MET Amplification

Sites in Chicago +17 more locations

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT07196644·Phase 2·Recruiting·Listed Sep 2025

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