Paid Clinical Trials in Illinois

Illinois has 2,968 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

for Major Depressive Disorder (MDD)

32 locations incl. New Haven

Sponsor: Cybin IRL Limited

Sex: All·Age: 18 - 85

Code: NCT06793397·Phase 3·Recruiting

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ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

for Breast Cancer, Metastatic

21 locations incl. Tucson

Sponsor: ALX Oncology Inc.

Sex: All·Age: 18+

Code: NCT07007559·Phase 2·Recruiting

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Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

for Miscellaneous Neoplasm, Nos

231 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07091617·Recruiting

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A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older

for Clostridioides Difficile Associated Disease

135 locations incl. Athens

Sponsor: Pfizer

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07282665·Phase 3·Recruiting

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Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody

for Clostridioides Difficile Infection

42 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07285213·Phase 2·Recruiting

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A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults

for Psoriatic Arthritis

Drug: Bimekizumab

28 locations incl. Peoria

Sponsor: UCB Biopharma SRL

Sex: All·Age: 18+

Code: NCT07290036·Phase 1·Recruiting

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A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

for Chronic Kidney Disease

Drug: Empagliflozin

30 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 2 - 17

Code: NCT07107945·Phase 3·Recruiting

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Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

29 locations incl. Anchorage

Sponsor: Incyte Corporation

Sex: Female·Age: 18+

Code: NCT07214779·Phase 3·Recruiting

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STM-06: POLARIS-POlymetastic Lesion Ablative Radiotherapy With Immunotherapy Study

for Advanced Solid Tumor

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07269080·Phase 1·Recruiting

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A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia

for Severe Hypertriglyceridemia

29 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07269210·Phase 2·Recruiting

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Phase 2 Study of SAT-3247 in Pediatric Ambulatory Patients

for Duchenne Muscular Dystrophy

7 locations incl. Los Angeles

Sponsor: Satellos Bioscience, Inc.

Sex: Male·Age: 7 - 9

Code: NCT07287189·Phase 2·Recruiting

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Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease

for Chronic Pain

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 15 - 39

Code: NCT07402811·Recruiting

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A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

for Rheumatoid Arthritis

Drug: RO7790121

12 locations incl. Peoria

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07137598·Phase 2·Recruiting

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Evaluating a Decreased Dose of Radiation Therapy to the Elective Neck for the Treatment of HPV-Related Oropharyngeal Cancer, ENLIGHT Trial

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07178301·Phase 2·Recruiting

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A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

18 locations incl. Surprise

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07222917·Phase 2·Recruiting

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Improving Diagnostic Safety Through STeatosis Identification, Risk Stratification, and Referral in the ED

for Non-Alcoholic Fatty Liver Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06944353·Enrolling By Invitation

Evaluating the Efficacy of OCM™ (Omeza® Complete Matrix) in the Treatment of Diabetic Foot Ulcers

for Diabetic Foot Ulcer

10 locations incl. Evergreen Park

Sponsor: Omeza, LLC

Sex: All·Age: 18+

Code: NCT07161830·Recruiting

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A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)

for Biliary Tract Cancer

Drug: Rilvegostomig

36 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07221253·Phase 3·Recruiting

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A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasis

for Plaque Psoriasis

Drug: Zasocitinib

11 locations incl. Chula Vista

Sponsor: Takeda

Sex: All·Age: 4 - 17

Code: NCT07250802·Phase 3·Recruiting

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A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

14 locations incl. Chula Vista

Sponsor: Akebia Therapeutics

Sex: All·Age: 18+

Code: NCT07268638·Phase 2·Recruiting

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A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

41 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07276399·Phase 3·Recruiting

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A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)

for Severe Asthma

34 locations incl. Northridge

Sponsor: Generate Biomedicines

Sex: All·Age: 12 - 80

Code: NCT07276724·Phase 3·Recruiting

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Dose Ranging Study of ORKA-001 in Patients With Moderate-to-Severe Plaque Psoriasis

for Plaque Psoriasis

20 locations incl. Phoenix

Sponsor: Oruka Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07290569·Phase 2·Recruiting

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A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

for Locally Advanced Urothelial Carcinoma

150 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06524544·Phase 3·Recruiting

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Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma

for Mesothelioma

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07126509·Recruiting

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A Study of DII235 in Adults With Elevated Lipoprotein(a)

for Lipoprotein Disorder

38 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT07235046·Phase 2·Recruiting

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Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

for Castration-Sensitive Prostate Carcinoma

Drug: Apalutamide

194 locations incl. Tucson

Sponsor: Alliance for Clinical Trials in Oncology

Sex: Male·Age: 18+

Code: NCT06931340·Phase 3·Recruiting

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Evaluating the Communication Between Patients and Providers in Cancer Clinics

for Cancer

3 locations incl. Chicago

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT06985953·Recruiting

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CBTi for the Treatment of Insomnia in Type 1 Diabetes

for Diabetes Mellitus Type 1

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 65

Code: NCT07091318·EARLY_Phase 1·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan

for Solid Tumors Harboring MET Amplification

16 locations incl. Beverly Hills

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT07196644·Phase 2·Recruiting

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Post-market Safety and Effectiveness of the CORUS-LX System in Improving Lumbar Interbody Fusion Outcomes

for Radiculopathy Lumbar

9 locations incl. Scottsdale

Sponsor: Providence Medical Technology, Inc.

Sex: All·Age: 18 - 80

Code: NCT07222787·Recruiting

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Prenatal Study in Healthy Pregnant Women

for Pregnancy

1 location in Chicago

Sponsor: Perelel Inc.

Sex: Female·Age: 21 - 40

Code: NCT07226414·Recruiting

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Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

for Carcinoma, Hepatocellular

Drug: PF-08634404

22 locations incl. Land O' Lakes

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227012·Phase 1, Phase 2·Recruiting

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Prospective Assessments Following Immediate Lymphatic Reconstruction

for Lymphatic Reconstruction

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07227467·Recruiting

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A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

for Small-cell Lung Cancer

28 locations incl. Aurora

Sponsor: Zai Lab (Shanghai) Co., Ltd.

Sex: All·Age: 18+

Code: NCT07218146·Phase 3·Recruiting

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Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities

for Actinic Keratosis

20 locations incl. Phoenix

Sponsor: Sun Pharmaceutical Industries, Inc.

Sex: All·Age: 18 - 85

Code: NCT07144852·Phase 3·Recruiting

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Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

for Type 2 Diabetes

60 locations incl. Chandler

Sponsor: Sparrow Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07296484·Phase 2·Recruiting

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A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

for Nausea

19 locations incl. Greenbrae

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07169851·Phase 2·Recruiting

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A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

30 locations incl. Goodyear

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07213674·Phase 3·Recruiting

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Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 70

Code: NCT07225361·Phase 4·Recruiting

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