Paid Clinical Trials in North Carolina

North Carolina has 2,812 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

Filter results

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

2,435 clinical trials

A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus

for Type II Diabetes Mellitus

Sites in Raleigh +30 more locations

Sponsor: Corxel Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT07340320·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

for Liver Cirrhosis

Drug: BI 3802876

Sites in Morehead City +25 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 75

Code: NCT07325526·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study

for Ventricular Arrythmia

Sites in Winston-Salem, Charlotte +25 more locations

Sponsor: AtaCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT07324031·Recruiting·Listed Jan 2026

Apply to this trial

A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)

for Metabolic Dysfunction-associated Steatohepatitis

Sites in Fayetteville +61 more locations

Sponsor: Eccogene

Sex: All·Age: 18 - 75

Code: NCT07288138·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

for Type 2 Diabetes

Sites in Chapel Hill, Greenville +58 more locations

Sponsor: Sparrow Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07296484·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

for Overweight

Drug: Eloralintide

Sites in Wilmington, Greensboro +58 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07282600·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

for CRC (Colorectal Cancer)

Drug: Bevacizumab

Sites in Chapel Hill, Charlotte +68 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07284849·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Advanced Non-Small Cell Lung Cancer

Drug: PF-08634404

Sites in Pinehurst, Wilson +191 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07222566·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older

for Clostridioides Difficile Associated Disease

Sites in Durham, Winston-Salem +133 more locations

Sponsor: Pfizer

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07282665·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

for Breast Neoplasms

Sites in Chapel Hill +27 more locations

Sponsor: Eli Lilly and Company

Sex: Female·Age: 18+

Code: NCT07287098·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

for Diabetic Kidney Disease (DKD)

Sites in Winston-Salem, Greenville +55 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT07271186·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

for Intestinal Neoplasms

Drug: PF-08634404

Sites in Durham, Raleigh +179 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07222800·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

for Diabetic Peripheral Neuropathic Pain

Sites in Asheville, Morehead City +68 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT07231419·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

Sites in Wilson +44 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07276399·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Study of Buntanetap in Participants With PD

for Parkinson's Disease (PD)

Sites in Durham +26 more locations

Sponsor: Annovis Bio Inc.

Sex: All·Age: 40 - 85

Code: NCT07284784·Phase 2, Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment

for Atopic Dermatitis

Sites in Winston-Salem, Huntersville +41 more locations

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT07290803·Recruiting·Listed Dec 2025

Apply to this trial

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Cancer

Drug: daraxonrasib

Sites in Durham +28 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT07252232·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

for Atopic Dermatitis

Drug: Tapinarof

Sites in Chapel Hill +35 more locations

Sponsor: Organon and Co

Sex: All·Age: 3 Months - 23 Months

Code: NCT07265479·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

for Carcinoma, Hepatocellular

Drug: PF-08634404

Sites in Durham, Raleigh +35 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227012·Phase 1, Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Sites in Durham +27 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07258511·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

for Untreated, Unresectable, or Metastatic Colorectal Cancer

Drug: Bevacizumab

Sites in Charlotte +44 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221357·Phase 2, Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

Drug: Semaglutide

Sites in Morehead City, Morrisville +25 more locations

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284979·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.

for Hidradenitis Suppurativa

Drug: Ritlecitinib

Sites in Charlotte +39 more locations

Sponsor: Pfizer

Sex: All·Age: 18 - 75

Code: NCT07228390·Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

for Obesity With Diabetes

Sites in Greensboro, Morehead City +37 more locations

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284901·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia

for Dystonia

Sites in Fayetteville +36 more locations

Sponsor: Vima Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07304089·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

Drug: Nivolumab

Sites in Chapel Hill +33 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221149·Phase 2, Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

Sites in Durham, Greensboro +64 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07220083·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

for Carcinoma, Transitional Cell

Sites in Charlotte +61 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07218380·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

for Metabolic Dysfunction-Associated Steatotic Liver Disease

Sites in Durham, Morehead City +139 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07165028·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder

for Bipolar I or II Disorder

Sites in Charlotte +45 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 65

Code: NCT07220460·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

for Breast Neoplasms

Sites in Chapel Hill, Asheville +116 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07174336·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

for Ovarian Neoplasms

Sites in Durham +87 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213804·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)

for Severe Asthma

Sites in Gastonia +34 more locations

Sponsor: Generate Biomedicines

Sex: All·Age: 12 - 80

Code: NCT07276724·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

for Alzheimers Disease

Sites in Greensboro +67 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 90

Code: NCT07177352·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

for Elevated Lp(a)

Drug: Muvalaplin

Sites in Greensboro, Fayetteville +128 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07157774·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for Transthyretin Amyloid Cardiomyopathy (ATTR CM)

Drug: Coramitug

Sites in Durham +59 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07207811·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

Sites in Winston-Salem, Charlotte +45 more locations

Sponsor: Incyte Corporation

Sex: Female·Age: 18+

Code: NCT07214779·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

Sites in Chapel Hill, Charlotte +92 more locations

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184931·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

for Cardiovascular Disease

Drug: Olpasiran

Sites in Durham, Winston-Salem +199 more locations

Sponsor: Amgen

Sex: All·Age: 50 - 105

Code: NCT07136012·Phase 3·Recruiting·Listed Aug 2025

Apply to this trial

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

for Diabetes Mellitus, Type 2

Drug: Empagliflozin

Sites in Chapel Hill, Winston-Salem +204 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07064473·Phase 3·Recruiting·Listed Jul 2025

Apply to this trial