Oncology Clinical Trials in Roanoke, VA
As of August 2026, 44 paid clinical trials are recruiting for Oncology in Roanoke, Virginia. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Filter results
44 clinical trials for Oncology
·Clear filters·Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
E-Mindfulness Approaches for Living After Breast Cancer
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
Project: Every Child for Younger Patients With Cancer
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma
Top Research Study Locations in Roanoke
Researchers run research studies in Roanoke, VA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Carilion Clinic | Focal Epilepsy, Heart Failure, Cardiovascular Diseases | 28 |
| Carilion Children's | B Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 15 |
| Carilion Roanoke Memorial Hospital | Malignant Female Reproductive System Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm, Recurrent Malignant Solid Neoplasm | 13 |
| Blue Ridge Cancer Care | Cancer of the Prostate, Follicular Lymphoma, Gastric Cancer | 12 |
| Fralin Biomedical Research Institute at VTC | Chronic Pain, Cigarette Smoking Behavior, Anxiety Disorder | 11 |
| Oncology and Hematology Associates of Southwest Virginia (BRCC) | Biliary Tract Cancer, Colorectal Cancer, Pancreatic Ductal Adenocarcinoma | 4 |
| Fralin Biomedical Research Institute | Development of LIFU for Clinical Purposes, Pain, Post Traumatic Stress Disorder | 3 |
| Gastroenterology Consultants of Southwest Virginia | Ulcerative Colitis, Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity or Overweight | 3 |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma, Carcinoma, Renal Cell | 3 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Carilion Children's Tanglewood Center | Crohn's Disease, Crohn's Disease (CD), Ulcerative Colitis | 2 |
| Clinical Trial Site | Juvenile Myoclonic Epilepsy, Lichen Planopilaris | 2 |
| Fairlawn Surgery Center | Dialysis; Complications, End Stage Renal Disease, Vascular Access Complication | 2 |
| Fralin Biomedical Research Institute at Virginia Tech Carilion | Cigarette Smoking, E-cigarette Use, Neurobehavioral Components of Reward and Loss Valuation | 2 |
| Gastroenterology Consultants of Southwest Virginia. | Crohn's Disease, Moderately to Severely Active Crohn Disease, Ulcerative Colitis | 2 |
| Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care | Breast Cancer, Breast Neoplasms, Colorectal Neoplasms | 2 |
| Oncology & Hematology Associates of Southwest Virginia, Inc. | Extensive-Stage Small Cell Lung Cancer, Melanoma | 2 |
| Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care | Advanced/Metastatic Urothelial Cancer, Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Carcinoma | 2 |
| Professional Education and Research Institute | Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers | 2 |
| Carilion Roanoke Memorial Hospital | Epithelial Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant | 2 |
| Vistar Eye Center | Diabetic Macular Edema, Age-Related Macular Degeneration, Choroidal Neovascularization | 2 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 1 |
| Anthos Investigative | Atrial Fibrillation (AF) | 1 |
| Artiva Investigational | IIM, Idiopathic Inflammatory Myopathies (IIMs), Myositis | 1 |
| Blue Ridge Cancer Care - 300202915 | Metastatic Colorectal Cancer | 1 |
Active & Upcoming Studies in Roanoke (2026)
Recruiting trials in Roanoke grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (58 active studies)
- A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03) · Phase 3 · EMD Serono Research & Development Institute, Inc.
- Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer · Phase 1, Phase 2 · Pfizer
Neurology & pain (10 active studies)
- A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic Epilepsy · Phase 2, Phase 3 · Jazz Pharmaceuticals
- LIFU for Chronic Pain and Generalized Anxiety Disorder · Virginia Polytechnic Institute and State University
Cardiovascular (9 active studies)
- A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. · P+F Products + Features USA Inc.
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · Amgen
Mental health & behavior (8 active studies)
- Generalized and Domain-Specific Episodic Thinking for Smoking Cessation · Virginia Polytechnic Institute and State University
- LIFU for Chronic Pain and Generalized Anxiety Disorder · Virginia Polytechnic Institute and State University
Diabetes & metabolic (7 active studies)
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
- Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study · Phase 3 · Eli Lilly and Company
Eye & vision (2 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Kamuvudine-9 (K9) in Diabetic Macular Edema · Phase 1, Phase 2 · Dr. Bryan Strelow
Pediatric (1 active study)
- The FBRI VTC Neuromotor Research Clinic · Virginia Polytechnic Institute and State University
Common conditions studied in Roanoke
- Ulcerative Colitis (5 active studies)
- Breast Neoplasms (4 active studies)
- Cardiovascular Diseases (4 active studies)
- Heart Failure (4 active studies)
- Prostate Cancer (4 active studies)
- B Acute Lymphoblastic Leukemia (3 active studies)
Leading research sponsors in Roanoke
- Virginia Polytechnic Institute and State University
- Merck Sharp & Dohme LLC
- Children's Oncology Group
- National Cancer Institute (NCI)
- Pfizer
Frequently asked questions
How many paid clinical trials are currently recruiting in Roanoke?
There are approximately 155 recruiting clinical trials in Roanoke, Virginia listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Roanoke pay participants?
Most recruiting trials in Roanoke compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Roanoke?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Roanoke?
The most common conditions under active study in Roanoke include Ulcerative Colitis (5), Breast Neoplasms (4), Cardiovascular Diseases (4), Heart Failure (4), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Roanoke?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Roanoke on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Roanoke?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Roanoke?
Recruiting research sites in Roanoke include Carilion Clinic, Carilion Children's, Carilion Roanoke Memorial Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Roanoke right now?
The largest active categories in Roanoke are Cancer & tumors (58), Neurology & pain (10), Cardiovascular (9). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.