Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin

Part of paid clinical trials in Memphis, Tennessee.

Sponsor: St. Jude Children's Research Hospital
Study ID: NCT00004005
Phase: PHASE2
Status: Completed

Conditions

Carcinoma of Unknown Primary
Colorectal Cancer
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific

Eligibility Criteria

Sex: ALL
Age: N/A - 24 Years
Healthy Volunteers: Not accepted

Interventions

fluorouracil — DRUG
irinotecan hydrochloride — DRUG
leucovorin calcium — DRUG
conventional surgery — PROCEDURE
radiation therapy — RADIATION

Study Details

RATIONALE: Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with radiation therapy works in treating patients with stage III or stage IV colorectal carcinoma (cancer), other refractory carcinoma (cancer), or metastatic adenocarcinoma (cancer) of unknown primary origin.