Bevacizumab and Docetaxel in Treating Older Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

Part of paid clinical trials in Detroit, Michigan.

Sponsor
Barbara Ann Karmanos Cancer Institute
Study ID
NCT00541099
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
75 Years - 120 Years
Healthy Volunteers
Not accepted

Interventions

  • bevacizumab — BIOLOGICAL
    Avastin 10.0 mg/kg on days 1 and 15
  • docetaxel — DRUG
    Dexamethasone 4 mg evening before, morning of and evening of each dose of docetaxel.Docetaxel 35 mg/m2 on day 1, 8, 15

Study Details

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as docetaxel, also work in different ways to kill tumor cells or stop them from growing. Giving bevacizumab together with docetaxel may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving bevacizumab together with docetaxel works in treating older patients with stage III or stage IV non-small cell lung cancer.

Key Dates

First listed
Oct 8, 2007
Start date
Jan 31, 2008
Status verified
Aug 2014
Primary completion
Jan 31, 2013
Completion
Jan 31, 2013

Study Design

Enrollment
11 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Avastin & Docetaxel
    Avastin 10.0 mg/kg on days 1 and 15; Dexamethasone 4 mg evening before, morning of and evening of each dose of docetaxel; Docetaxel 35 mg/m2 on day 1, 8, 15

Primary Outcome Measure

Survival [ Time Frame: 6 months when treated with combination of Avastin and weekly docetaxel ]

Locations (3)

FacilityCityStateZIPSite coordinators
Barbara Ann Karmanos Cancer InstituteDetroitMichigan48201-1379-
Nevada Cancer InstituteLas VegasNevada89135-
Case Comprehensive Cancer CenterClevelandOhio44106-

Find similar trials in Detroit, MI

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Barbara Ann Karmanos Cancer Institute· Detroit, MINevada Cancer Institute· Las Vegas, NVCase Comprehensive Cancer Center· Cleveland, OH

Related Studies