A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
AstraZeneca
Study ID
NCT01195662
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 89 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to learn if BMS-512148 (Dapagliflozin), after 12 weeks, can improve (decrease) blood pressure in patients with type 2 diabetes with uncontrolled hypertension who are on an Angiotensin-converting enzyme inhibitor (ACEI) or an Angiotensin Receptor Blocker (ARB).The safety of this treatment will also be studied

Key Dates

Start date
Oct 31, 2010
Status verified
Dec 2015
Primary completion
Feb 28, 2013
Completion
Feb 28, 2013

Study Design

Enrollment
2,245 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Dapagliflozin 10 mg
    Dapagliflozin 10 mg tablets
  • Placebo Comparator: Placebo matching Dapagliflozin
    Placebo tablets matching dapagliflozin tablets

Primary Outcome Measure

Adjusted Mean Change From Baseline in Seated Systolic Blood Pressure for 12 Week Double-Blind Treatment Period - Randomized Participants [ Time Frame: Baseline to Week 12 ]

Locations (155)

FacilityCityStateZIPSite coordinators
University Of Alabama At BirminghamBirminghamAlabama35294-
Medical Affiliated Research Center, Inc.HuntsvilleAlabama35801-
Wilmax Clinical Research, Inc.MobileAlabama36608-
43rd Medical AssociatesPhoenixArizona85051-
Central Phoenix Medical CenterTempeArizona85282-
Clinical Research Advantage, Inc./Mesa Family Med Ctr, PcTempeArizona85282-
Clinical Research Advantage/Desert Clinical ResearchTempeArizona85282-
Eclipse Clinical ResearchTucsonArizona85745-
Visions Clinical Research - TucsonTucsonArizona85712-
Aureus Research, Inc.Little RockArkansas72211-
Preferred Research Partners, Inc.Little RockArkansas72211-
Cmp ResearchAnaheimCalifornia92805-
Catalina Research Institute, LlcChinoCalifornia91710-
Southland Clinical Research Center, Inc.Fountain ValleyCalifornia92708-
Marin Endocrine Care & Research, Inc.GreenbraeCalifornia94904-
Del Rosario Medical Clinic, Inc.Huntington ParkCalifornia90255-
Time Clinical Research Inc.Huntington ParkCalifornia90255-
American Institute Of ResearchLos AngelesCalifornia90017-
Clinica Medica San MiguelLos AngelesCalifornia90015-
Mcs Clinical TrialsLos AngelesCalifornia90057-
National Research InstLos AngelesCalifornia90057-
Randall G. Shue, D.O.Los AngelesCalifornia90023-
Diabetes Medical Center Of CaliforniaNorthridgeCalifornia91325-
Valley Clinical TrialsNorthridgeCalifornia91325-
Lucita M. Cruz,Md.,Inc.NorwalkCalifornia90650-
Sds Clinical TrialsOrangeCalifornia92868-
Bayview Research Group, LlcParamountCalifornia90723-
San Diego Managed Care GroupPowayCalifornia92064-
Integrated Research Group, Inc.RiversideCalifornia92506-
Quality Control Research, IncSacramentoCalifornia95842-
Wetlin Research Associates, Inc.San DiegoCalifornia92120-
Crest Clinical Trials, Inc.Santa AnaCalifornia92701-
Neurological Research InstituteSanta MonicaCalifornia90404-
Orrin M. Troum, Md And Medical AssociatesSanta MonicaCalifornia90404-
Torrance Clinical ResearchTorranceCalifornia90505-
Orange County Research CenterTustinCalifornia92780-
University Clinical Investigators, Inc.TustinCalifornia92780-
Chase Medical Research, LlcWaterburyConnecticut06708-
Christiana Care Health Services, IncNewarkDelaware19713-
Zasa Clinical ResearchBoynton BeachFlorida33472-
Bradenton Research Center, Inc.BradentonFlorida34205-
Innovative Research Of West Florida, IncClearwaterFlorida33756-
Clinical Research Of South FloridaCoral GablesFlorida33134-
Avail Clinical Research, LlcDeLandFlorida32720-
International Research Associates, LlcHialeahFlorida33012-
Palm Springs Research InstituteHialeahFlorida33012-
The Community Research Of South FloridaHialeahFlorida33016-
Central Florida InternistsKissimmeeFlorida34741-
Apf Research, LlcMiamiFlorida33135-
Baptist Diabetes Associates, PaMiamiFlorida33156-
Clinical Research Of Miami, Inc.MiamiFlorida33126-
Community Research Foundation, Inc.MiamiFlorida33155-
Flcri Global Research, LlcMiamiFlorida33125-
Pharmax Research Clinic, Inc.MiamiFlorida33126-
Newphase Clinical Trials, Inc.Miami BeachFlorida33140-
Ocean Blue Medical Research Center, Inc.Miami SpringsFlorida33166-
Suncoast Clinical Research, Inc.New Port RicheyFlorida34652-
Florida Institute For Clinical Research, LlcOrlandoFlorida32822-
Michele A. Morrison Internal Medicine, Inc.Pembroke PinesFlorida33026-
Medsol Clinical Research CenterPort CharlotteFlorida33952-
Meridien ResearchTampaFlorida33606-
Perimeter Institute For Clinical ResearchAtlantaGeorgia30338-
Bainbridge Medical AssociatesBainbridgeGeorgia39819-
River Birch Research Alliance, LlcBlue RidgeGeorgia30513-
In-Quest Medical Research, LlcDuluthGeorgia30096-
Middle Georgia Drug Study Center, LlcPerryGeorgia31069-
Cedar Crosse Research CenterChicagoIllinois60607-
So. Illinois Clin Res Ctr @ Div Of Kevin L Pritchett Md, PcO'FallonIllinois62269-
Springfield Diabetes And Endocrine CenterSpringfieldIllinois62704-
American Health Network Of Indiana LlcAvonIndiana46123-
Investigators Research Group, LlcBrownsburgIndiana46112-
American Health Network Of In LlcFranklinIndiana46131-
Laporte County Institute For Clinical Research, Inc.Michigan CityIndiana46360-
American Health Network Of In LlcMuncieIndiana47304-
Medical Development Centers, LlcBaton RougeLouisiana70808-
Omega Clinical Research, LlcMetairieLouisiana70006-
Acadia Clinical Research, LlcBangorMaine04401-
Alternative Primary CareSilver SpringMaryland20910-
Hci-Metromedic Walk-In Medical OfficeNew BedfordMassachusetts02740-
Neurocare, Inc.NewtonMassachusetts02459-
Atlantic Clinical Trials, LlcWatertownMassachusetts02472-
Providence Park Clinical ResearchNoviMichigan48374-
The Center For Clinical TrialsBiloxiMississippi39531-
Phillips Medical Services, PllcJacksonMississippi39209-
Jefferson City Medical GroupJefferson CityMissouri65109-
Kcumb Dybedal Clinical Research CenterKansas CityMissouri64106-
Clin Research Advantage, Inc. James Meli, Do Family PraciceHendersonNevada89014-
Clinical Research Advantage, Inc.Las VegasNevada89128-
Independent Clinical Researchers@ Wolfson Medical CenterLas VegasNevada89103-
Office Of Ted Thorp, MdLas VegasNevada89102-
Palm Medical Research CenterLas VegasNevada89148-
Comprehensive Clinical ResearchBerlinNew Jersey08009-
Premier ResearchTrentonNew Jersey08611-
Medex Healthcare Research, Inc.New YorkNew York10022-
Digiovanna Institute For Medical Education & ResearchNorth MassapequaNew York11758-
Southgate Medical GroupWest SenecaNew York14224-
Diabetes & Endocrinology ConsultantsMorehead CityNorth Carolina28557-
Burke Primary CareMorgantonNorth Carolina28655-
Lillestol ResearchFargoNorth Dakota58103-
Community Health Care, Inc.Canal FultonOhio44614-
Community ResearchCincinnatiOhio45227-
Parsons Avenue Medical ClinicalColumbusOhio43207-
Clinical Research Source, IncPerrysburgOhio43551-
Sooner Clinical ResearchOklahoma CityOklahoma73112-
Integris Family Care YukonYukonOklahoma73099-
Willamette Valley Clinical StudiesEugeneOregon97404-
Southeastern Pa Medical InstituteBroomallPennsylvania19008-
Abington Memorial Hos/Feasterville Family Health Care CenterFeastervillePennsylvania19053-
The Clinical Trial Center, LlcJenkintownPennsylvania19046-
Arcuri Clinical Research LlcPhiladelphiaPennsylvania19142-
Philadelphia Health Associates - Adult MedicinePhiladelphiaPennsylvania19146-
Research Across AmericaReadingPennsylvania19606-
Pish Medical AssociatesUniontownPennsylvania15401-
Greater Providence Clinical Research, LlcWarwickRhode Island02888-
Medical Research SouthCharlestonSouth Carolina29407-
Southeastern Research Associates, Inc.GreenvilleSouth Carolina29605-
North Myrtle Beach Family PracticeNorth Myrtle BeachSouth Carolina29582-
Pawleys Pediatrics And Adult MedicinePawleys IslandSouth Carolina29585-
Hillcrest Clinical Reseach, LlcSimpsonvilleSouth Carolina29681-
Palmetto Clinical ResearchSummervilleSouth Carolina29485-
Southwind Medical SpecialistsMemphisTennessee38125-
Tn Medical ResearchSpring HillTennessee37174-
Arlington Family Research Center, Inc.ArlingtonTexas76012-
3rd Coast Research AssociatesCorpus ChristiTexas78414-
Internal Medicine Clinical ReaseachDallasTexas75235-
Krk Medical ResearchDallasTexas75230-
Renaissance Clinical Research And Hypertension PllcDallasTexas75235-
Research Institute Of DallasDallasTexas75231-
Sergio F. Rovner, M.D.El PasoTexas79925-
Bellaire Medical Care GroupHoustonTexas77081-
Dependable Clinical Research, LlcHoustonTexas77074-
Excel Clinical Research, LlcHoustonTexas77081-
Pioneer Research Solutions, Inc.HoustonTexas77008-
Southwest Clinical TrialsHoustonTexas77074-
Village Family PracticeHoustonTexas77024-
Hill Country Medical AssociatesNew BraunfelsTexas78130-
North Hills Medical Research, Inc.North Richland HillsTexas76180-
Med-Olam Clinical ResearchPasadenaTexas77504-
Lisa E. Medwedeff, Md, PaPlanoTexas75024-
Abbott Clinical Research Group, Inc.San AntonioTexas78224-
Covenant Clinical Research, PaSan AntonioTexas78229-
Innovative Clinical TrialsSan AntonioTexas78229-
Sun Research InstituteSan AntonioTexas78215-
Breco Research, LtdSugarlandTexas77479-
Exodus Healthcare NetworkMagnaUtah84044-
Wasatch Clinical ResearchSalt Lake CityUtah84107-
Wasatch Endocrinology And Diabetes SpecialistsSalt Lake CityUtah84102-
Alexandria Health Care CenterAlexandriaVirginia22314-
Millennium Clinical Trials LlcArlingtonVirginia22203-
Burke Internal Medicine And ResearchBurkeVirginia22015-
Manassas Clinical Research CenterManassasVirginia20110-
Hampton Roads Center For Clinical Research, Inc.SuffolkVirginia23435-
Larry D. Stonesifer, MdFederal WayWashington98003-
Sound Medical ResearchPort OrchardWashington98366-
Clinical Investigation Specialists, Inc.KenoshaWisconsin53142-

Find similar trials in Birmingham, AL

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University Of Alabama At Birmingham· Birmingham, ALMedical Affiliated Research Center, Inc.· Huntsville, ALWilmax Clinical Research, Inc.· Mobile, AL43rd Medical Associates· Phoenix, AZCentral Phoenix Medical Center· Tempe, AZClinical Research Advantage, Inc./Mesa Family Med Ctr, Pc· Tempe, AZ

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