The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study.

Sponsor
Skane University Hospital
Study ID
NCT01270087
Phase
PHASE4
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to determine whether anti-inflammatory treatment with adalimumab (Humira) reduces endothelial activation in blood vessels in patients with active rheumatoid arthritis. Markers of endothelial activation are assessed in muscle tissue before treatment and after 3 months, and related to other biomarkers and clinical outcomes.

Key Dates

Start date
May 31, 2005
Status verified
Jan 2007
Primary completion
Feb 28, 2007
Completion
Feb 28, 2007

Study Design

Enrollment
14 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Other: Adalimumab

Primary Outcome Measure

Endothelial expression of HLA-DQ in muscle biopsies [ Time Frame: 3 months ]

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