Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation

Part of paid clinical trials in Raleigh, North Carolina.

Sponsor
North Carolina State University
Study ID
NCT05308368
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • Ultrasound Imaging — DEVICE
    We will collect ultrasound images during the grasping motion for both groups
  • Electromyography — DEVICE
    We will collect electromyography (EMG) signals of both the flexor and extensor muscles of the wrist during the grasping motion for both groups
  • Inertial Measurement Units (IMU) — DEVICE
    We will use data from the ultrasound images and EMG to develop a tremor model. The model will be validated in comparison to joint angle measurements from an Inertial Measurement Unit (IMU) collected during the grasping motion
  • Functional Electrical Stimulation (FES) — DEVICE
    We will use the develop closed-loop control methods for tremor suppression using information from the ultrasound-image based tremor models. FES will be used to provide stimulation that will help with tremor suppression

Study Details

Individuals experiencing tremors face difficulty performing activities of daily living caused by involuntary oscillation of the muscles in the hands and arms. Current solutions to help suppress tremors include medication, surgery, assistive devices and lifestyle change. However, each of these has a drawback of its own including cost and unwanted side effects. Aside from the solutions listed, it has been shown that functional electrical stimulation (FES) is a possible solution to help suppress tremor. Additionally, FES can be combined with different technologies including accelerometers, gyroscopes and motion capture to develop a closed loop system for tremor suppression. However, this has drawbacks including signal interference and the need for multiple sensor to fully classify the tremor. Ultrasound imaging solves some of these issues because it can provide a direct visualization of hand muscles that contribute to tremor. This study will focus on detecting characterizing and differentiating tremors from voluntary hand motion using ultrasound imaging. The results obtained from this study will help design FES-based tremor-suppression techniques in the future. This study will target both subjects with different tremor disorders and able bodied subjects.

Key Dates

Start date
Apr 11, 2021
Status verified
Oct 2025
Primary completion
Jul 31, 2025
Completion
Jul 31, 2025

Study Design

Enrollment
12 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Tremor Group
    Individuals with either parkinson's disease or essential tremor will be recruited in this group
  • Experimental: Able Body Group
    Individuals with no disorders will be recruited in this group

Primary Outcome Measure

Tremor Model Accuracy [ Time Frame: Through Completion of Study, an average of 3 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Engineering Building IIIRaleighNorth Carolina27606-

Find similar trials in Raleigh, NC

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
Engineering Building III· Raleigh, NC

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