Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project

Sponsor
University of Leicester
Study ID
NCT05649800
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Study Details

The goal of this observational study is to determine the feasibility of using integrated Transcranial Doppler Ultrasonography or Near Infrared Spectroscopy to detect changes in cerebral autoregulation and neurovascular coupling in healthy, stroke, dementia, depression and delirium populations. We also aim to: * Determine the optimal stimulus for neurovascular coupling * To derive sample size estimates for a future study * To develop a multilevel, multivariate model that can be applied to future datasets

Key Dates

First listed
Dec 14, 2022
Start date
Mar 17, 2023
Status verified
Nov 2025
Primary completion
Nov 26, 2025
Completion
Aug 26, 2026

Study Design

Enrollment
140 participants (estimated)

Arms

  • Arm: Healthy
    Healthy adults ages over 65 years
  • Arm: Stroke
    Stroke patients aged over 65 years
  • Arm: Dementia
    Dementia patients aged over 65 years
  • Arm: Depression
    Depression patients aged over 65 years
  • Arm: Delirium
    Delirium patients aged over 65 years

Primary Outcome Measure

Good quality TCD-NIRS data [ Time Frame: 3 years ]

Central Contacts

Find similar trials

Nationwide
Depression trialsStroke trialsPsychiatry trialsMental health trialsBehavioral health trialsNeurology trialsBrain disorders trials

Related Studies