ME-344 and Bevacizumab in Previously Treated Metastatic Colorectal Cancer

Part of paid clinical trials in Los Angeles, California.

Sponsor
MEI Pharma, Inc.
Study ID
NCT05824559
Phase
PHASE1
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ME-344 — DRUG
    ME-344 will be administered intravenously (IV)
  • Bevacizumab — DRUG
    Bevacizumab will be administered intravenously (IV)

Study Details

This is a Phase 1b open-label, multiple dose/schedule sequential study to determine the safety and efficacy of the oxidative phosphorylation (OxPhos) pathway inhibitor ME-344 in combination with bevacizumab in subjects with recurrent mCRC.

Key Dates

First listed
Apr 21, 2023
Start date
Aug 7, 2023
Status verified
Jun 2024
Primary completion
Jul 9, 2024
Completion
Jul 23, 2024

Study Design

Enrollment
23 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: ME-344 and Bevacizumab
    ME-344 (IV) Cohort 1: Days 1, 8, and 15 of each 28-day cycle. Cohort 2: Days 1 and 15 of each 28-day cycle. Bevacizumab (IV) Cohorts 1 and 2: Days 1 and 15 of each 28-day cycle.

Primary Outcome Measure

Progression Free Survival (PFS) Rate at 16 Weeks [ Time Frame: 16 weeks ]

Locations (7)

FacilityCityStateZIPSite coordinators
University of Southern CaliforniaLos AngelesCalifornia90033-
Mount Sinai MiamiMiami BeachFlorida33140-
Johns HopkinsBaltimoreMaryland21218-
Rutgers UniversityNew BrunswickNew Jersey08901-
Mt Sinai New YorkNew YorkNew York10029-
Vanderbilt -Ingram Cancer CenterNashvilleTennessee37232-
University of UtahSalt Lake CityUtah84108-

Find similar trials in Los Angeles, CA

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
University of Southern California· Los Angeles, CAMount Sinai Miami· Miami Beach, FLJohns Hopkins· Baltimore, MDRutgers University· New Brunswick, NJMt Sinai New York· New York, NYVanderbilt -Ingram Cancer Center· Nashville, TN

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