Assessing Brain Metabolism Using MRS With Deuterated Glucose

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT06594315
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Deuterated Glucose — DRUG
    Given orally
  • Magnetic Resonance Imaging (MRI) — PROCEDURE
    Imaging procedure performed at University of California, San Francisco
  • Blood Sample — PROCEDURE
    Capillary blood from the fingertip
  • MR spectroscopy (MRS) — PROCEDURE
    Imaging procedure performed at University of California, San Francisco

Study Details

This study will investigate the use of Hydrogen 1 (1H) magnetic resonance spectroscopy (MRS) with deuterated glucose (2H-glucose) to detect dynamic glucose uptake in the brain.

Key Dates

First listed
Sep 19, 2024
Start date
Jul 20, 2022
Status verified
Aug 2026
Primary completion
Jul 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
80 participants (estimated)

Arms

  • Arm: Cohort 1: Healthy Controls
    Twenty healthy controls for will have 2H-glucose metabolism in measured for development of robust strategy in optimizing acquisition parameters.
  • Arm: Cohort 2: Glioma participants (Single Time point)
    Thirty participants with glioma who may or may not have received prior treatment for testing the optimized imaging protocol developed in Cohort 1.
  • Arm: Cohort 3: Glioma participants (Multiple Time points)
    Thirty participants who will receive non-investigational treatment for glioma enrolled to test the evaluation for treatment induced metabolic changes at baseline and post- non-investigational treatment.

Primary Outcome Measure

Signal-to-noise ratio (Cohort 1 & 2) [ Time Frame: Day of imaging (1 day) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, San FranciscoSan FranciscoCalifornia94143
Wendy Ma
[email protected]
415-514-4418
[email protected]
877-827-3222
Yan Li, PhD (PRINCIPAL_INVESTIGATOR)

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