Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
VA Office of Research and Development
Study ID
NCT06857851
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Study Details

Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment and strabismus, frequently affects the quality of life in patients with Parkinson's disease. The investigators study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence and strabismus by integrating the patient-specific deep brain stimulation models and high-resolution eye-tracking measures. The knowledge gained will allow the investigators to find the most beneficial stimulation location and parameters for improving binocular coordination, strabismus, and vergence while preserving the ability to treat motor symptoms in Parkinson's disease.

Key Dates

First listed
Mar 4, 2025
Start date
Feb 1, 2026
Status verified
Jul 2026
Primary completion
Sep 30, 2029
Completion
Oct 1, 2029

Study Design

Enrollment
80 participants (estimated)

Arms

  • Arm: Parkinson's disease with DBS
    This is the only group. The patients in this group will have bilateral subthalamic region deep brain stimulator. They will be recruited after they are therapeutically optimized on stimulation as well as medical therapy.

Primary Outcome Measure

Eye alignment - vergence gain [ Time Frame: One month ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Louis Stokes VA Medical Center, Cleveland, OHClevelandOhio44106-1702
Cheryl Dudek
[email protected]
216-679-3800
Aasef G Shaikh, MD PhD
[email protected]
(216) 791-3800
Aasef G. Shaikh, MD PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Cleveland, OH

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
Louis Stokes VA Medical Center, Cleveland, OH· Cleveland, OH

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