Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis
for Spinal Cord Injury/Disorder
1 location in Cleveland
Sponsor: Louis Stokes VA Medical Center
Sex: All·Age: 18+
Code: NCT07768761·Recruiting·Listed Aug 17, 2026
Brain disorders Clinical Trials in Cleveland, OH
As of August 2026, 49 paid clinical trials are recruiting for Brain disorders in Cleveland, Ohio. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Filter results
Filter results
Newly added in Cleveland
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Understanding and Enhancing Human Health and Movement
for Spinal Cord Injury
1 location in Cleveland
Sponsor: Louis Stokes VA Medical Center
Sex: All·Age: 18+
Code: NCT07738978·Recruiting·Listed Jul 31, 2026
51 clinical trials for Brain disorders
·Clear filters· Email me when a new brain disorders trial opens in Cleveland, OH.
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
for Parkinson Disease
Sites in Cleveland, Columbus +28 more locations
Sponsor: Appello Pharmaceuticals, Inc.
Sex: All·Age: 30 - 80
Code: NCT07432958·Phase 2·Recruiting·Listed Feb 2026
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
for Parkinson's Disease
Sites in Cleveland +25 more locations
Sponsor: Bayer
Sex: All·Age: 45 - 75
Code: NCT07330258·Recruiting·Listed Jan 2026
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
for Parkinson's Disease
Drug: Prasinezumab
Sites in Cleveland, Canton +48 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 50 - 85
Code: NCT07174310·Phase 3·Recruiting·Listed Sep 2025
Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
for Agitation
Sites in Cleveland +47 more locations
Sponsor: Celgene
Sex: All·Age: 55 - 90
Code: NCT06808984·Phase 2·Recruiting·Listed Feb 2025
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
for Relapsing Multiple Sclerosis
Sites in Cleveland, Toledo +88 more locations
Sponsor: TG Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06433752·Recruiting·Listed May 2024
A Study of CREXONT (Carbidopa and Levodopa) Extended-Release Capsules in Participants With Parkinson's Disease
for Parkinson Disease
Sites in Cleveland, Canton +25 more locations
Sponsor: Impax Laboratories, LLC
Sex: All·Age: 18+
Code: NCT06765668·Phase 4·Recruiting·Listed Jan 2025
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
for Huntington Disease
Sites in Cleveland +28 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 21 - 70
Code: NCT07326709·Phase 3·Recruiting·Listed Jan 2026
Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
for Epilepsy
Sites in Cleveland +15 more locations
Sponsor: Epiminder America, Inc.
Sex: All·Age: 18 - 75
Code: NCT07110454·Recruiting·Listed Aug 2025
A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis
for Generalized Myasthenia Gravis
Drug: Remibrutinib
Sites in Cleveland, Cincinnati +22 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 18 - 85
Code: NCT06744920·Phase 3·Recruiting·Listed Dec 2024
Pilot/Pivotal Study of DBS+Rehab After Stroke
for Stroke
Sites in Cleveland +8 more locations
Sponsor: Enspire DBS Therapy, Inc.
Sex: All·Age: 21+
Code: NCT05701280·Recruiting·Listed Jan 2023
A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis
for Myasthenia Gravis
Drug: Nipocalimab
Sites in Cleveland +10 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18+
Code: NCT04951622·Phase 3·Recruiting·Listed Jul 2021
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
for Movement Disorders
Sites in Cleveland, Columbus +6 more locations
Sponsor: Abbott Medical Devices
Sex: All·Age: All ages
Code: NCT04071847·Recruiting·Listed Aug 2019
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
for Focal Seizure
Sites in Cleveland +9 more locations
Sponsor: Rapport Therapeutics Inc.
Sex: All·Age: 18 - 75
Code: NCT07563881·Phase 3·Recruiting·Listed May 2026
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
for Alzheimer Disease
Drug: KarXT
Sites in Cleveland, Independence +3 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 55 - 90
Code: NCT06947941·Phase 3·Recruiting·Listed Apr 2025
A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures
for Focal Epilepsy
Sites in Cleveland +6 more locations
Sponsor: Rapport Therapeutics Inc.
Sex: All·Age: 18 - 70
Code: NCT07219407·Phase 2·Recruiting·Listed Oct 2025
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
for Multiple Sclerosis
1 location in Cleveland
Sponsor: Cionic, Inc.
Sex: All·Age: 22 - 75
Code: NCT05964829·Recruiting·Listed Jul 2023
Bridging the Gap: Educating Patients on Social Determinants of Health to Improve Epilepsy Surgery Access and Outcomes
for Epilepsy
1 location in Cleveland
Sponsor: Anny Reyes
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07509190·Recruiting·Listed Apr 2026
Central Vein Sign in Multiple Sclerosis Extension Study
for Multiple Sclerosis
Sites in Cleveland +2 more locations
Sponsor: The Cleveland Clinic
Sex: All·Age: 18 - 65
Code: NCT07424027·Recruiting·Listed Feb 2026
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
for Frontotemporal Lobar Degeneration (FTLD)
Sites in Cleveland +24 more locations
Sponsor: Mayo Clinic
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT04363684·Recruiting·Listed Apr 2020
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
for Stroke
Sites in Cleveland, Akron +26 more locations
Sponsor: Yale University
Sex: All·Age: 18+
Code: NCT05907629·Recruiting·Listed Jun 2023
The Fourth Left Atrial Appendage Occlusion Study
for Atrial Fibrillation
Sites in Cleveland, Canton +45 more locations
Sponsor: Hamilton Health Sciences Corporation
Sex: All·Age: 18+
Code: NCT05963698·Recruiting·Listed Jul 2023
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
for Cognitive Impairment, Mild
Sites in Cleveland, Columbus +89 more locations
Sponsor: Duke University
Sex: All·Age: 75+·Accepts healthy volunteers
Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020
Personalized Real-Time DBS and PD Mechanisms
for Parkinson Disease
1 location in Cleveland
Sponsor: David Escobar
Sex: All·Age: 18 - 80
Code: NCT06013956·Phase 4·Recruiting·Listed Aug 2023
Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage
for Intracerebral Hemorrhage
Sites in Cleveland, Akron +18 more locations
Sponsor: Zeenat Qureshi Stroke Institute
Sex: All·Age: 18 - 100
Code: NCT06402968·Recruiting·Listed May 2024
CTSN Embolic Protection Trial
for Delirium
Sites in Cleveland +18 more locations
Sponsor: Icahn School of Medicine at Mount Sinai
Sex: All·Age: 60+
Code: NCT06027788·Recruiting·Listed Sep 2023
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
for Tremor
1 location in Cleveland
Sponsor: The Cleveland Clinic
Sex: All·Age: 21+
Code: NCT07049003·Phase 1·Recruiting·Listed Jul 2025
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
for Intracerebral Hemorrhage
Sites in Cleveland, Akron +140 more locations
Sponsor: Yale University
Sex: All·Age: 18+
Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019
Telerehabilitation In The Home After Stroke
for Stroke
Sites in Cleveland, Cincinnati +25 more locations
Sponsor: University of California, Los Angeles
Sex: All·Age: 18 - 80
Code: NCT06682429·Recruiting·Listed Nov 2024
Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease
for Parkinson Disease
1 location in Cleveland
Sponsor: The Cleveland Clinic
Sex: All·Age: 18+
Code: NCT07110376·Recruiting·Listed Aug 2025
Evaluation of an Advanced Lower Extremity Neuroprostheses
for Spinal Cord Injuries
2 locations in Cleveland
Sponsor: Case Western Reserve University
Sex: All·Age: 21 - 75
Code: NCT00623389·Recruiting·Listed Feb 2008
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
for Parkinson Disease
Sites in Cleveland, Cincinnati +28 more locations
Sponsor: Michael J. Fox Foundation for Parkinson's Research
Sex: All·Age: 30+·Accepts healthy volunteers
Code: NCT04477785·Recruiting·Listed Jul 2020
Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease
for Parkinson's Disease
1 location in Cleveland
Sponsor: VA Office of Research and Development
Sex: All·Age: All ages
Code: NCT06857851·Recruiting·Listed Mar 2025
Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery
for Epilepsy
1 location in Cleveland
Sponsor: Kayela Arrotta
Sex: All·Age: 18 - 60
Code: NCT05992402·Recruiting·Listed Aug 2023
Healthy Aging in People With Epilepsy Program
for Epilepsy
1 location in Cleveland
Sponsor: Anny Reyes
Sex: All·Age: 55 - 90·Accepts healthy volunteers
Code: NCT06052605·Recruiting·Listed Sep 2023
Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial
for Parkinson Disease
1 location in Cleveland
Sponsor: Jay Alberts
Sex: All·Age: 18+
Code: NCT06442033·Recruiting·Listed Jun 2024
BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease
for Parkinson Disease
1 location in Cleveland
Sponsor: The Cleveland Clinic
Sex: All·Age: 40+
Code: NCT07138560·Phase 4·Recruiting·Listed Aug 2025
Care in Multiple Sclerosis (MS)
for Multiple Sclerosis
Sites in Cleveland +5 more locations
Sponsor: NYU Langone Health
Sex: All·Age: 18+
Code: NCT07011914·Recruiting·Listed Jun 2025
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
for Essential Tremor
1 location in Cleveland
Sponsor: The Cleveland Clinic
Sex: All·Age: 30 - 80·Accepts healthy volunteers
Code: NCT06293638·Recruiting·Listed Mar 2024
Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
for Parkinson Disease
Sites in Cleveland +10 more locations
Sponsor: Michael J. Fox Foundation for Parkinson's Research
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT06719583·Recruiting·Listed Dec 2024
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
for Atrial Fibrillation
Sites in Cleveland +34 more locations
Sponsor: Icahn School of Medicine at Mount Sinai
Sex: All·Age: 18+
Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019
Top Research Study Locations in Cleveland
Researchers run research studies in Cleveland, OH at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Cleveland Clinic | Heart Failure, Cardiovascular Diseases, Atrial Fibrillation | 354 |
| University Hospitals Cleveland Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 156 |
| Cleveland Clinic Foundation | COPD, Heart Failure, Recurrent Endometrial Carcinoma | 142 |
| Case Western Reserve University | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Metastatic Malignant Neoplasm in the Brain | 80 |
| MetroHealth Medical Center | Spinal Cord Injuries, Spinal Cord Injury Cervical, Stage IVB Prostate Cancer AJCC v8 | 37 |
| The Cleveland Clinic Foundation | Aortic Valve Insufficiency, Cardiovascular Diseases, Heart Diseases | 27 |
| Louis Stokes VA Medical Center, Cleveland, OH | Spinal Cord Injury, Diabetes, Parkinson's Disease | 24 |
| Rainbow Babies and Childrens Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Down Syndrome | 24 |
| Cleveland Clinic Main Campus | Breast Cancer, Abdominal Wall Hernia, Blood Pressure | 19 |
| The Cleveland Clinic | Depression / Major Depressive Disorder, Hopelessness, Suicidal Ideation | 17 |
| Cleveland Clinic Cancer Center/Fairview Hospital | Ovarian Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Breast Cancer | 14 |
| University Hospitals | Chronic Pain, B Cell Lymphoma, Bladder Pain Syndrome | 13 |
| UH Cleveland Medical Center | Breast Cancer, Acute Decompensated Heart Failure, Atrial Fibrillation | 11 |
| University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center | Acute Lymphocytic Leukemia, Bile Duct Cancer, Brain Metastases | 11 |
| University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center | Pancreatic Cancer, Acute Lymphatic Leukemia, Acute Myelogenous Leukemia | 11 |
| Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center | Acute Myeloid Leukemia, Cyst of Pancreas, Cytokine Release Syndrome | 10 |
| University Hospitals of Cleveland | Advanced Solid Tumors, Aortic Aneurysm, Aortic Dissection | 9 |
| Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute | Amyloid Light-chain Amyloidosis, B-cell Non Hodgkin Lymphoma, Basal Cell Carcinoma | 8 |
| Cleveland Clinic Taussig Cancer Center | Glioma, Advanced Solid Tumor, Advanced or Metastatic Solid Tumors | 8 |
| The MetroHealth System | AV Block, COVID-19, Coronavirus Infections | 8 |
| University Hospitals Cleveland | 1st Line NSCLC, Abdominal Aortic Aneurysm, Advanced Solid Tumor | 8 |
| Cleveland Clinic Fairview Hospital | HPV Infection, Pre-Cancerous Dysplasia, Bleeding | 7 |
| Louis Stokes Cleveland VA Medical Center | Multiple Sclerosis, Stroke, Adenocarcinoma of the Colon | 7 |
| MetroHealth | Acute Kidney Injury, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 7 |
| Case Comprehensive Cancer Center, Cleveland Clinic Foundation | Head and Neck Cancer, Oral Cancer, Cancer | 6 |
Active & Upcoming Studies in Cleveland (2026)
Recruiting trials in Cleveland grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (384 active studies)
- TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) · Case Comprehensive Cancer Center
- A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma · Phase 3 · AbbVie
Cardiovascular (103 active studies)
- Metabolic Surgery for Atrial Fibrillation Elimination · Phase 4 · Ali Aminian
- A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. · P+F Products + Features USA Inc.
Neurology & pain (85 active studies)
- REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis · Case Western Reserve University
- A Study of Remibrutinib Using MR Imaging in Relapsing or Progressive MS · Phase 2 · Moein Amin
Diabetes & metabolic (34 active studies)
- Whole Gut Motility Abnormalities Following GLP-1 Receptor Agonist (GLP-1RA) Initiation · The Cleveland Clinic
- PNS to Improve Vascular Function and Limb Health in Veterans · VA Office of Research and Development
Eye & vision (17 active studies)
- Study of Serine Supplementation to Protect Vision in MacTel · Phase 3 · The Lowy Medical Research Institute Limited
- A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated · Phase 1, Phase 2 · Boehringer Ingelheim
Mental health & behavior (15 active studies)
Pediatric (15 active studies)
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction · Phase 3 · Bayer
- Humidity Asthma Interventions for Low Socioeconomic Status Children · Case Western Reserve University
HIV / STI (6 active studies)
- Dasatinib for HIV-1 Reservoir Reduction · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Menopausal HT for Women Living With HIV (HoT) · Phase 4 · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Vaccines (5 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease · Phase 2 · Shionogi
Common conditions studied in Cleveland
- Heart Failure (28 active studies)
- Breast Cancer (19 active studies)
- Advanced Solid Tumor (18 active studies)
- Cardiovascular Diseases (17 active studies)
- Prostate Cancer (16 active studies)
- Acute Myeloid Leukemia (15 active studies)
Leading research sponsors in Cleveland
- The Cleveland Clinic
- Case Comprehensive Cancer Center
- National Cancer Institute (NCI)
- University Hospitals Cleveland Medical Center
- Case Western Reserve University
Frequently asked questions
How many paid clinical trials are currently recruiting in Cleveland?
There are approximately 1,259 recruiting clinical trials in Cleveland, Ohio listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Cleveland pay participants?
Most recruiting trials in Cleveland compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Cleveland?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Cleveland?
The most common conditions under active study in Cleveland include Heart Failure (28), Breast Cancer (19), Advanced Solid Tumor (18), Cardiovascular Diseases (17), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Cleveland?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Cleveland on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Cleveland?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Cleveland?
Recruiting research sites in Cleveland include Cleveland Clinic, University Hospitals Cleveland Medical Center, Cleveland Clinic Foundation, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Cleveland right now?
The largest active categories in Cleveland are Cancer & tumors (384), Cardiovascular (103), Neurology & pain (85). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
Other cities in Ohio
Columbus, OH(1,362)Cincinnati, OH(1,080)Dayton, OH(181)Canton, OH(148)Toledo, OH(123)Akron, OH(121)Centerville, OH(80)West Chester, OH(59)Mayfield Heights, OH(53)Franklin, OH(52)Beachwood, OH(51)Greenville, OH(50)Westlake, OH(49)Mentor, OH(48)Troy, OH(48)Dublin, OH(45)Kettering, OH(42)Maumee, OH(42)Sylvania, OH(40)Marion, OH(37)Westerville, OH(34)Zanesville, OH(30)Beavercreek, OH(29)Avon, OH(28)Mansfield, OH(28)Middleburg Heights, OH(28)Springfield, OH(27)Youngstown, OH(27)Lima, OH(26)Boardman, OH(25)Delaware, OH(25)Athens, OH(24)Newark, OH(24)Perrysburg, OH(24)Chillicothe, OH(23)Independence, OH(23)Belpre, OH(22)North Canton, OH(20)Mount Vernon, OH(19)Portsmouth, OH(19)Fairborn, OH(18)Findlay, OH(18)Gahanna, OH(18)Grove City, OH(18)Marietta, OH(18)Marysville, OH(17)Pickerington, OH(17)Hilliard, OH(16)Lancaster, OH(15)Mason, OH(15)New Albany, OH(15)Sandusky, OH(15)Chardon, OH(14)Parma, OH(14)Warren, OH(14)Wooster, OH(14)Springboro, OH(12)Fairfield, OH(10)Blue Ash, OH(9)Liberty Township, OH(9)