A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

Part of paid clinical trials in Sun City West, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT06972472
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Orforglipron — DRUG
    Administered orally
  • Placebo — DRUG
    Administered orally

Study Details

The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with overweight and type 2 diabetes. This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.

Key Dates

Start date
May 19, 2025
Status verified
Apr 2026
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Orforglipron Dose 1
    Participants will receive orforglipron orally
  • Experimental: Orforglipron Dose 2
    Participants will receive orforglipron orally
  • Experimental: Orforglipron Dose 3
    Participants will receive orforglipron orally
  • Experimental: Orforglipron Dose 4
    Participants will receive orforglipron orally
  • Placebo Comparator: Placebo
    Participants will receive placebo orally

Primary Outcome Measure

Change from Baseline in Hemoglobin A1c (HbA1c) [ Time Frame: Baseline, Week 40 ]

Locations (35)

FacilityCityStateZIPSite coordinators
Clinical Research Institute of Arizona (CRI) - Sun City WestSun City WestArizona85375-
Novak Clinical Research - Tucson - North La Cholla BoulevardTucsonArizona85741-
Norcal Endocrinology & Internal MedicineSan RamonCalifornia94583-
Southern California Clinical ResearchSanta AnaCalifornia92701-
Care Access - Thousand OaksThousand OaksCalifornia91360-
Accel Research Sites - DeLand Clinical Research UnitDeLandFlorida32720-
Innovation Medical Research Center - Fort LauderdaleFort LauderdaleFlorida33316-
Indago Research & Health Center, IncHialeahFlorida33012-
Encore Medical ResearchHollywoodFlorida33024-
West Orange Endocrinology P.A.OcoeeFlorida34761-
Care Access - TampaTampaFlorida33625-
Conquest ResearchWinter ParkFlorida32789-
Accel Research Sites - NeuroStudies Clinical Research UnitDecaturGeorgia30030-
Care Access - DecaturDecaturGeorgia30030-
Javara - Privia Medical Group Georgia - SavannahSavannahGeorgia31406-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Solaris Clinical ResearchMeridianIdaho83646-
Care Access - New IberiaNew IberiaLouisiana70560-
Endocrine and Metabolic ConsultantsRockvilleMaryland20852-
Javara - Privia Medical Group - Silver SpringSilver SpringMaryland20901-
Great Lakes Research Group, Inc.Bay CityMichigan48706-
Boeson Research MSOMissoulaMontana59804-
Javara - Nevada Health Centers - Carson CityCarson CityNevada89706-
The Machuca FoundationLas VegasNevada89101-
University of North Carolina Medical CenterChapel HillNorth Carolina27514-
Javara - Tryon Medical PartnersCharlotteNorth Carolina28210-
Care Access - FayettevilleFayettevilleNorth Carolina28314-
The Corvallis Clinic, P.C.CorvallisOregon97330-
Clinical Research of PhiladelphiaPhiladelphiaPennsylvania19114-
Frontier Clinical Research, LLCSmithfieldPennsylvania15478-
Velocity Clinical Research, DallasDallasTexas75230-
Biopharma Informatic, LLCHoustonTexas77043-
Activian Clinical ResearchKingwoodTexas77339-
Texas Valley Clinical Research (TVCR) - MissionMissionTexas78572-
Consano Clinical Research, LLCShavano ParkTexas78231-

Find similar trials in Sun City West, AZ

By condition
Obesity / overweightType 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Clinical Research Institute of Arizona (CRI) - Sun City West· Sun City West, AZNovak Clinical Research - Tucson - North La Cholla Boulevard· Tucson, AZNorcal Endocrinology & Internal Medicine· San Ramon, CASouthern California Clinical Research· Santa Ana, CACare Access - Thousand Oaks· Thousand Oaks, CAAccel Research Sites - DeLand Clinical Research Unit· DeLand, FL

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