Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes

Sponsor
University Hospital, Toulouse
Study ID
NCT07075133
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
45 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Antidiabetic diet (control) — OTHER
    Standard antidiabetic diet
  • eTRE diet — OTHER
    eTRE for a total duration of 12 weeks. During the eTRE, volunteers will have to eat and drink (meals + snacks, medication) exclusively during an 8-hour period which will extend between 6 a.m. (flexible: or 7 a.m. or 8 a.m.) in the morning and 2 p.m. (depending on the chosen start time: or 3 p.m. or 4 p.m.), which corresponds to a fasting period of 16 hours per day
  • Physical activity in the morning — OTHER
    Physical exercise will consist of 3 weekly morning sessions that will combine aerobic and resistance exercises
  • Physical activity in the afternoon — OTHER
    The physical exercise will consist of 3 weekly afternoon sessions that will combine aerobic and resistance exercises.

Study Details

The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary endpoint

Key Dates

First listed
Jul 20, 2025
Start date
Sep 15, 2026
Status verified
May 2026
Primary completion
Jul 15, 2029
Completion
Jul 15, 2029

Study Design

Enrollment
45 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Diet control (no chrono restriction) + exercise performed in the morning
    Patients following a standard antidiabetic diet combined with morning exercise
  • Experimental: eTRE (chrono restriction) + exercise performed in the morning
    Patients following the eTRE program combined with physical exercise performed in the morning
  • Experimental: eTRE (chrono restriction) + exercise performed in the afternoon
    Patients following the eTRE program combined with physical exercise performed in the afternoon

Primary Outcome Measure

Change in skeletal muscle function [ Time Frame: 4 years ]

Central Contacts

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