Atrial fibrillation Clinical Trials

Recruiting atrial fibrillation studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat atrial fibrillation. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting atrial fibrillation studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting atrial fibrillation trials

Within

Conscious Sedation Study

for Atrial Fibrillation

Sponsor: Conformal Medical, Inc

Sex: All·Age: 18+

Code: NCT06049615

The Effectiveness of Patch-Based Screening for Pre-Symptomatic Atrial Fibrillation to Improve Patient Outcome

for Atrial Fibrillation

1 site in Palo Alto

Sponsor: VA Office of Research and Development

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06953778

OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation

for Atrial Fibrillation (AF)

Sponsor: Ewha Womans University Mokdong Hospital

Sex: All·Age: 18+

Code: NCT07496281·Phase 4

Registry on Luma Vision's VERAFEYE System (ENLIgHT)

for Atrial Fibrillation

Sponsor: LUMA Vision Ltd.

Sex: All·Age: 18+

Code: NCT06293430

Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

for Surgery, Cardiac

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05543278·Phase 4

ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3

for Atrial Fibrillation

Sponsor: Milestone Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06716021·Phase 3

Relaxin Therapy for Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Deeptankar DeMazumder

Sex: All·Age: 18+

Code: NCT07359872·Phase 1, Phase 2

Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation)

for Atrial Fibrillation (AF)

Sponsor: Muhammad Ali Javed

Sex: All·Age: 18+

Code: NCT07706075·Phase 4

An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation

for Atrial Fibrillation (AF)

Sponsor: Ewha Womans University Mokdong Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07708818

Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG

for Atrial Fibrillation

Sponsor: I.M. Sechenov First Moscow State Medical University

Sex: All·Age: 18+

Code: NCT07348991

Computerized Decision Support to Prevent Stroke in Atrial Fibrillation

for Atrial Fibrillation

2 sites incl. Edgewood

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06355986

FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)

for Atrial Fibrillation (AF)

Sponsor: Ewha Womans University Mokdong Hospital

Sex: All·Age: 18+

Code: NCT07497893

Metabolic Surgery for Atrial Fibrillation Elimination

for Atrial Fibrillation

1 site in Cleveland

Sponsor: Ali Aminian

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07027969·Phase 4

Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: University of Luebeck

Sex: All·Age: 18+

Code: NCT07389941·Phase 4

Isolation of Pulmonary Veins Using the Box Technique in Patients Undergoing Sternotomy

for Atrial Fibrillation (AF)

Sponsor: Nantes University Hospital

Sex: All·Age: 18+

Code: NCT07312149

AI-Assisted Workflow for Occult Atrial Fibrillation Detection After Ischemic Stroke: A Prospective Randomized Trial

for Atrial Fibrillation

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18+

Code: NCT07540065

Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients

for Atrial Fibrillation

Sponsor: University of Calgary

Sex: All·Age: 18+

Code: NCT04748991·Phase 3

Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18+

Code: NCT07405671·Phase 4

AF-CARD Registry (Real-World Clinical Practice Registry of Patients With Atrial Fibrillation)

for Atrial Fibrillation (AF)

Sponsor: Eurasian Association of Therapists

Sex: All·Age: 18 - 64

Code: NCT07437456

Cardiologist-Administered Midazolam vs. Anaesthesiologist-Assisted Propofol Sedation For Transoesophageal Echocardiography-Guided Cardioversion of Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Gødstrup Hospital

Sex: All·Age: 18+

Code: NCT07571447·Phase 4

Effectiveness of Patch-Electrocardiogram Recorders in Screening for Atrial Fibrillation in Elderly People in the Chinese Community

for Atrial Fibrillation

Sponsor: Beijing Anzhen Hospital

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07627672

Prospective Study on the Effectiveness and Safety of Bi-polar Pulse-field Tip-catheter Ablation for Atrial Fibrillation in China（POTENTIAL-AF）

for Atrial Fibrillation

Sponsor: Beijing Anzhen Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07627685

Wearable Device-Assisted Remote Management to Improve Prognosis in Patients With Acute Heart Failure Complicated by Atrial Fibrillation: WARM-HF Trial (Stage 2)

for Atrial Fibrillation (AF)

Sponsor: Beijing Anzhen Hospital

Sex: All·Age: 18+

Code: NCT07687862

Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients

for Atrial Fibrillation

Sponsor: Yunlong Wang

Sex: All·Age: 18 - 75

Code: NCT07715929·Phase 4

Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase Inhibitor Therapy

for Atrial Fibrillation (AF)

3 sites incl. Duarte

Sponsor: Tina Baykaner

Sex: All·Age: 18+

Code: NCT07711327

A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation

for Atrial Fibrillation

18 sites incl. Birmingham

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT07527299

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EPX-HTG for Structural Heart Procedures

for Atrial Fibrillation (AF)

1 site in Sacramento

Sponsor: EchoPixel, Inc.

Sex: All·Age: 18+

Code: NCT07705425

Novel Model of Integrated Care of Older Patients With Atrial Fibrillation to Prevent Heart Failure in Rural China

for Atrial Fibrillation

Sponsor: Jiangsu Taizhou People's Hospital

Sex: All·Age: 65 - 80

Code: NCT07492498

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Novel Model of Integrated Care of Older Patients With Atrial Fibrillation and Heart Failure in Rural China (MIRACLE-AFHF)

for Atrial Fibrillation

Sponsor: Jiangsu Taizhou People's Hospital

Sex: All·Age: 65 - 80

Code: NCT07492524

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Tirzepatide on Atrial Fibrillation Recurrence After Catheter Ablation in Patients With Obesity and HFpEF

for Atrial Fibrillation

Sponsor: Yunlong Wang

Sex: All·Age: 18 - 80

Code: NCT07630454·Phase 4

CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction)

for Atrial Fibrillation

Sponsor: Tulane University

Sex: All·Age: 18 - 120

Code: NCT07254455

Hummingbird ICE Study

for ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT07552272

AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: University Medical Center Groningen

Sex: All·Age: 18+

Code: NCT07604727

Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07626411·Phase 3

Exclusion of Left Atrial Appendage Thrombus in Emergency Department Patients With Atrial Fibrillation Undergoing CT to Assess for Pulmonary Embolus: A Feasibility Study

for Atrial Fibrillation (AF)

1 site in Manhasset

Sponsor: Northwell Health

Sex: All·Age: 18+

Code: NCT07647939

Association Between Circulating BDNF Levels and Atrial Cardiomyopathy in Patients Undergoing Ablation for Persistent Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Centre Hospitalier Universitaire Dijon

Sex: All·Age: 18+

Code: NCT07648329

Globe Registry: Globe® Pulsed Field System Registry Study for Treating Patients With Symptomatic Atrial Fibrillation

for Atrial Fibrillation

Sponsor: Kardium Inc.

Sex: All·Age: 18+

Code: NCT07651852

BOdygUardian MOnitoriNg for ReCurrencE of AF

for Atrial Fibrillation (AF)

3 sites incl. Delray Beach

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT07671677

Repeatable Evaluation of Functional Intra-procedural Signals for Effect in Pulsed Field Ablation REFINE-PFA

for Atrial Fibrillation

2 sites incl. Ypsilanti

Sponsor: CathVision ApS

Sex: All·Age: 21+

Code: NCT07275151

A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

for Atrial Fibrillation

6 sites incl. San Francisco

Sponsor: Bayer

Sex: All·Age: 18 - 85

Code: NCT07625215·Phase 2

Atrial Cardiomyopathy in Patients With Cardiovascular-Kidney-Metabolic Syndrome: Non-invasive Characterization

for Cardiovascular-Kidney-Metabolic Syndrome

Sponsor: Grigore T. Popa University of Medicine and Pharmacy

Sex: All·Age: 18+

Code: NCT07697469

PulseMagic™ TrueForce™ PAF NMPA Study

for Atrial Fibrillation (AF)

Sponsor: Shanghai MicroPort EP MedTech Co., Ltd.

Sex: All·Age: 18+

Code: NCT07720557

throMboembolic Risk Associated To High atrIal Fibrillation riSk

for MACE

Sponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Sex: All·Age: 65 - 95·Accepts healthy volunteers

Code: NCT07441759

PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF

for Atrial Fibrillation (AF)

Sponsor: Ewha Womans University Mokdong Hospital

Sex: All·Age: 20 - 80·Accepts healthy volunteers

Code: NCT06929897

Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair

for Atrial Fibrillation (AF)

Sponsor: Atrial Fibrillation Network

Sex: All·Age: 18+

Code: NCT07380932

Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly

for Atrial Fibrillation (AF)

Sponsor: Beijing Anzhen Hospital

Sex: All·Age: 80+

Code: NCT07403760

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A Study of Varipulse Catheter in Participants With Paroxysmal Atrial Fibrillation Under Optimized Sedation

for Atrial Fibrillation

Sponsor: Johnson & Johnson Medical (Shanghai) Ltd.

Sex: All·Age: 18 - 80

Code: NCT07511166

PULSed Field Ablation for Atrial Fibrillation Using a Balloon for Early Intervention - Study

for Atrial Fibrillation

Sponsor: Asklepios proresearch

Sex: All·Age: 18+

Code: NCT07621003

Atrial Remodeling After PFA Substrate Modification for Persistent AF (PeAF)

for Persistent Atrial Fibrillation

Sponsor: Taipei Veterans General Hospital, Taiwan

Sex: All·Age: 18+

Code: NCT07675395

SMART-VERAPAF: Self-MAnagement and Random Therapy With VERApamil or Metoprolol in Paroxysmal Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Martini Hospital Groningen

Sex: All·Age: 18+

Code: NCT07445789·Phase 4

ALPs Single ChambEr New Device

for Bradycardia

Sponsor: Cairdac SA

Sex: All·Age: 18+

Code: NCT07461935

Nudging for Anticoagulation Adherence in Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07543393

LBBAP vs. CS Pacing for CRT in Permanent Atrial Fibrillation and Heart Failure (SYNC-AF)

for Atrial Fibrillation (AF)

Sponsor: Yonsei University

Sex: All·Age: 19+

Code: NCT07560891

A Study Of Stellate Ganglion Blockade With Liposomal Bupivacaine In Preventing Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting Surgery

for Coronary Artery Disease

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 40+

Code: NCT07570940·Phase 4

The Effect of Low-Level Tragus Stimulation on Inflammation and Early Recurrence After Pulsed Field Ablation: A Randomized Controlled Study

for Atrial Fibrillation

Sponsor: Xi'an Jiaotong University

Sex: All·Age: 18 - 80

Code: NCT07633431

Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation

for Atrial Fibrillation (AF)

Sponsor: China National Center for Cardiovascular Diseases

Sex: All·Age: 18 - 80

Code: NCT07630857

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OPTION-EMEA Clinical Trial

for Atrial Fibrillation (AF)

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07349121

Apply to this trial

VOLta Medical AI-software in REal-World During AF Ablation

for Atrial Fibrillation

Sponsor: Volta Medical

Sex: All·Age: 18+

Code: NCT07621055

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The COMBINE-AF Trial

for Atrial Fibrillation (AF)

Sponsor: Yunlong Wang

Sex: All·Age: 18 - 75

Code: NCT07633509

Diaphragmatic Evaluation by Fluoroscopy to Identify Phrenic Nerve Dysfunction Related to Electroporation

for Atrial Fibrillation

Sponsor: French Cardiology Society

Sex: All·Age: 18+

Code: NCT07462910

Apply to this trial

Atrial fibrillation clinical trials — common questions

Are atrial fibrillation clinical trials free to join?

Yes. Participating in a atrial fibrillation clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a atrial fibrillation clinical trial?

Each atrial fibrillation study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a atrial fibrillation trial near me?

Use the location controls above. We'll show recruiting atrial fibrillation trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many atrial fibrillation trials are recruiting right now?

We're currently tracking roughly 101 recruiting atrial fibrillation trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Atrial fibrillation trials by city

Birmingham, AL San Francisco, CA Chicago, IL Cleveland, OH Boston, MA Jonesboro, AR Stanford, CA Evanston, IL Jacksonville, FL Portland, OR Tampa, FL

Related specialties

Cardiology Heart disease