Cardiovascular Risk in Children With Chronic Conditions Study

Sponsor
Semmelweis University
Study ID
NCT07086989
Status
Recruiting
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Conditions

  • Aorta Stenosis
  • Bone Marrow Transplant
  • Cancer (Solid Tumors)
  • Chronic Kidney Disease
  • Coarctation of Aorta
  • Dyslipaemia
  • Familial Hypercholesterolaemia
  • HIV Infection
  • Hypertension
  • Inflammatory Bowel Disease (IBD)
  • Juvenile Idiopahtic Arthritis
  • Kawasaki Disease
  • Kidney Transplant
  • Leukemia
  • Lipoprotein(a)
  • Liver Transplant
  • Lymphoma
  • Non Alcoholic Fatty Liver Disease
  • Obesity and Overweight
  • Pulmonary Hypertension
  • Systemic Lupus Erthematosus
  • Transposition of Great Arteries
  • Type 1 Diabetes Mellitus (T1DM)
  • Type 2 Diabetes Mellitus (T2DM)
  • White Coat Hypertension

Eligibility Criteria

Sex
ALL
Age
6 Years - 25 Years
Healthy Volunteers
Not accepted

Study Details

Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels. Although experts recognize this elevated risk and recommend close monitoring and early intervention, the underlying mechanisms driving this phenomenon remain poorly understood. At present, no effective interventions specifically target its root causes. Recent research shows that both large blood vessels (such as the carotid artery) and small vessels (such as those in the retina) can display early signs of damage decades before clinically apparent heart or vascular disease emerges. This accelerated vascular aging can result from multiple factors - including disease-related processes such as persistent inflammation and metabolic disturbances, treatment-related effects such as chemotherapy or long-term steroid use, and lifestyle changes associated with chronic illness, such as reduced physical activity and altered eating habits. However, it is still unclear how these factors influence the development and progression of vascular changes in children as they grow. Importantly, these changes can be monitored through non-invasive methods, offering a unique opportunity to study at-risk patients many years before overt cardiovascular disease develops. Identifying these early changes may enable us to detect and track individuals at heightened risk well in advance of clinical disease. This study aims to deepen our understanding of the causes of increased cardiovascular risk in children with chronic conditions and to lay the groundwork for earlier, more targeted prevention strategies.

Key Dates

First listed
Jul 25, 2025
Start date
Apr 1, 2025
Status verified
Aug 2025
Primary completion
Jan 31, 2029
Completion
Jan 31, 2029

Study Design

Enrollment
300 participants (estimated)

Primary Outcome Measure

Arterial stiffness [ Time Frame: At baseline and at the time of annual follow-up ]

Central Contacts

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