MRinRT: Swansea University and SWWCC Collaboration Study.

Sponsor
Swansea Bay University Health Board
Study ID
NCT07365124
Status
Not Yet Recruiting

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Conditions

  • Brain (Nervous System) Cancers
  • Carcinoma
  • Gastric Cancer
  • Glioblastoma
  • MRI
  • MRI Image Enhancement
  • MRI Scanner Configuration
  • MRI-guided Adaptive Radiotherapy
  • Oesophageal Carcinoma
  • Pancreas Carcinoma
  • Radiotherapy

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • MRI — OTHER
    This is an observational study with no interventions. Participants will undergo MRI scanning for research purposes and radiotherapy treatment will be delivered as per standard of care for the participants tumour type.

Study Details

The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone. The main questions it aims to answer is: * Can MRI scan images be adjusted to make the tumour and normal tissues easier to see? * Does adding MRI to a radiotherapy planning CT make the radiotherapy plan more precise? * Can MRI be used to adjust a radiotherapy plan during a course of treatment to make it more precise, and might that reduce the side effects? * Are there particular MRI scans that can predict how a tumour will respond to radiotherapy or how likely the patient is to have side effects? This study will assess current MRI scanning procedures and ensure these are adjusted to best suit radiotherapy planning. It will also provide pilot data evaluating: 1. MRI-adapted radiotherapy Usually, radiotherapy plans are based on a pre-treatment planning CT scan. Unless an issue is detected the patient would complete their whole course of radiotherapy on this plan. This does not account for changes in position/size/shape of the tumour that occur over the whole treatment course. Clinicians therefore increase the size of the tumour/target to account for these uncertainties, which can increase side effects. This study will assess the potential to reduce side effects from radiotherapy by using repeat MRI scans and replanning during the treatment course (MRI-adaptive radiotherapy). 2. Imaging biomarkers MRI sequences can be used to predict response to radiotherapy or chance of developing side effects. This study will identify potential MRI sequences that may be used as imaging biomarkers, to guide the development of future clinical trials. The study will be undertaken at SBUHB, lasting 4 years, and involving ≤15 healthy volunteers and ≤150 patients.

Key Dates

First listed
Jan 26, 2026
Start date
May 31, 2026
Status verified
Dec 2025
Primary completion
Jan 31, 2030
Completion
Jan 31, 2032

Study Design

Enrollment
165 participants (estimated)

Arms

  • Arm: Healthy Volunteer
    Volunteers with no history of any medical issue which may affect the scan interpretation and who are eligible for MRI scanning
  • Arm: Patient
    Patients with the tumour of interest who are due to undergo radiotherapy and are eligible for MRI scanning

Primary Outcome Measure

Optimisation of MRI images 1 [ Time Frame: From enrolment to analysis, on average 4-6 weeks ]

Central Contacts

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