Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology

Conditions

• Head and Neck Cancer
• Malignant Pleural Mesothelioma
• Small Cell Lung Cancer

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Blood and Tissue Collection — OTHER
  Samples will be collected at baseline (prior to treatment), over four cycles of therapy, at six months, and at disease progression. When available, formalin-fixed paraffin-embedded (FFPE) tissue samples will also be obtained. Tissue samples of the biopsy or additional biopsy done as part of standard of care during the course of treatment will also be collected if available. Specimen number of the biopsy or additional biopsy done as part of standard of care during the course of treatment will also be collected. Specimen number for tissue will be collected to reference for future tissue collection.

Study Details

This is an ancillary laboratory study to collect and bank blood and tissue samples. The biospecimens collected for this study will be invaluable for future research into predictive biomarkers and genomic alterations and their correlation with clinical outcomes.

Key Dates

First listed

Apr 24, 2026

Start date

Apr 30, 2026

Status verified

Apr 2026

Primary completion

Apr 30, 2029

Completion

Apr 30, 2029

Study Design

Enrollment

110 participants (estimated)

Arms

• Arm: Stage IIIB, IIIC or IV Non-small cell lung cancer
  Participants with non-small cell lung cancer.
• Arm: Extensive-stage Small-cell lung cancer
  Participants with extensive stage small-cell lung cancer.
• Arm: Metastatic squamous cell Head and Neck cancer
  Participants with metastatic squamous-cell head and neck cancer.
• Arm: Malignant Pleural Mesothelioma
  Participants with advanced malignant pleural mesothelioma.

Primary Outcome Measure

Establish a comprehensive blood and tissue biobank [ Time Frame: Samples will be collected at baseline (prior to treatment), over four cycles of therapy, at six months, and at disease progression; total participant duration minimum of 1 year ]

Central Contacts

• Margana Whyte
  (913) 945-6050
  [email protected]

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